metronidazole has been researched along with Carcinoma, Epidermoid in 36 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of radiation therapy were compared in 217 patients at advanced stages of cancer of the tongue (131) and fundus of the mouth (86) using split courses of conventional (SCF) and dynamic fractionation (SDF) and SDF combined with metronidazole." | 3.68 | [Probit analysis in assessing the results of radiation therapy of disseminated cancer of the tongue and floor of the mouth]. ( Limarova, IV; Ustinskov, VI; Vorob'ev, IuI, 1990) |
| "To evaluate efficacy and side effects of glycididazole sodium (CMNa) combined with chemotherapy (cisplatin plus 5-FU/folic acid, PLF) and radiotherapy in treating patients with locally advanced nasopharyngeal carcinoma." | 2.79 | Glycididazole sodium combined with radiochemotherapy for locally advanced nasopharyngeal carcinoma. ( Chen, DP; Li, MY; Liang, YY; Liu, JQ; Qi, B; Yin, WJ, 2014) |
| "Patients with locoregional advanced laryngeal cancer (stage T3-4,N0-3,M0) were included: group 1(control, n=30)were not administered of sodium glycididazole; group 2 (test, n=30) received sodium glycididazole at a dose of 700 mg/m(2) intravenous infusion 30 minutes before radiotherapy three times a week." | 2.75 | Safety and radiation-enhancing effect of sodium glycididazole in locoregionally advanced laryngeal cancers previously treated with platinum-containing chemotherapy regimens: A preliminary report. ( Chen, W; Chen, XD; Chi, F; Dong, XQ; Fan, GL; Hao, SH; Jia, MX; Jin, XY; Li, X; Li, Y; Wang, EY; Wang, SL; Wang, YM; Wu, LN; Wu, R; Xia, HH; Xiao, FD; Xu, ZG; Zeng, YC; Zhang, HB; Zhang, LB; Zhang, XY; Zhang, ZY; Zheng, W, 2010) |
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| "Proceeding from the clinical observation of 11 patients with cancer of the tongue, oral mucosa and stomatopharynx who received gamma-beam therapy according to the scheme of dynamic fractionation combined with metronidazole, it has been concluded that the drug enhances the degree of radiation injury of the above tumors." | 1.27 | [Cell kinetics of oral cancer during gamma teletherapy in combination with the administration of metronidazole]. ( Dar'ialova, SL; Karakulov, RK; Kiseleva, ES; Pelevina, II; Poliakov, PIu, 1983) |
| "Metronidazole was administered per os 3 = 4 h before irradiation with fractions I, III and V of each phase of a split course." | 1.27 | [Radiotherapy, using metronidazole, of regional lymph node metastases of cancer of the oral mucosa]. ( Limarova, IV, 1986) |
| "The results of combined treatment of 98 laryngeal cancer patients followed up for 1." | 1.27 | [Combined (radiation and surgical) treatment of laryngeal cancer patients using metronidazole]. ( Andreev, VG, 1985) |
| "An unusually advanced case of squamous cell carcinoma of the lip is presented." | 1.26 | Carcinoma of the lip--a case presentation. ( Lawson, VG; Rider, WD, 1978) |
| "Metronidazole was administered orally to 25 patients and its maximum concentration in blood and tumor tissues, its ability to cross the blood/brain barrier and concentrate in the cerebrospinal fluid and brain tumor tissue, its immediate and long-term toxicity, and its enhancement of irradiation in normal tissue were studied." | 1.25 | Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells. ( Band, P; Chapman, JD; Fryer, CG; Rabin, HR; Sturmwind, J; Urtasun, RC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (69.44) | 18.7374 |
| 1990's | 3 (8.33) | 18.2507 |
| 2000's | 5 (13.89) | 29.6817 |
| 2010's | 3 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, MY | 1 |
| Liu, JQ | 1 |
| Chen, DP | 1 |
| Qi, B | 1 |
| Liang, YY | 1 |
| Yin, WJ | 1 |
| Lai, MJ | 1 |
| Chiueh, TS | 1 |
| Huang, ZY | 1 |
| Lin, JC | 1 |
| Zeng, YC | 1 |
| Wu, R | 1 |
| Xu, ZG | 1 |
| Zhang, XY | 1 |
| Fan, GL | 1 |
| Wu, LN | 1 |
| Wang, YM | 1 |
| Hao, SH | 1 |
| Zheng, W | 1 |
| Chen, XD | 1 |
| Chi, F | 1 |
| Zhang, ZY | 1 |
| Li, X | 1 |
| Jin, XY | 1 |
| Chen, W | 1 |
| Wang, SL | 1 |
| Xiao, FD | 1 |
| Wang, EY | 1 |
| Dong, XQ | 1 |
| Zhang, LB | 1 |
| Jia, MX | 1 |
| Xia, HH | 1 |
| Zhang, HB | 1 |
| Li, Y | 1 |
| Ballinger, JR | 1 |
| Hsue, V | 1 |
| Rauth, AM | 1 |
| WALL, JA | 1 |
| KAUFMAN, RH | 1 |
| CONNERS, JS | 1 |
| Schreiber, A | 1 |
| Krause, M | 1 |
| Zips, D | 1 |
| Dörfler, A | 1 |
| Richter, K | 1 |
| Vettermann, S | 1 |
| Petersen, C | 1 |
| Beuthien-Baumann, B | 1 |
| Thümmler, D | 1 |
| Baumann, M | 1 |
| Aiken, K | 1 |
| West, D | 1 |
| Tokita, H | 1 |
| Tanaka, N | 1 |
| Sekimoto, K | 1 |
| Ueno, T | 1 |
| Okamoto, K | 1 |
| Fujimura, S | 1 |
| Stewart, DJ | 2 |
| Maroun, JA | 1 |
| Young, V | 1 |
| Crook, AF | 1 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Bélanger, R | 1 |
| Heringer, R | 1 |
| Vorob'ev, IuI | 2 |
| Limarova, IV | 3 |
| Karakulov, RK | 2 |
| Poliakov, PIu | 2 |
| Dar'ialova, SL | 2 |
| Kiseleva, ES | 1 |
| Pelevina, II | 2 |
| Mann, W | 1 |
| Pelz, K | 1 |
| Orr, LE | 1 |
| Puthawala, A | 1 |
| Syed, AM | 1 |
| Fleming, PA | 1 |
| Cripps, MC | 1 |
| Lamothe, A | 1 |
| Laframboise, G | 1 |
| Odell, P | 1 |
| Gerin-Lajoie, J | 1 |
| Connor, JP | 1 |
| Elam, G | 1 |
| Goldberg, JM | 1 |
| Dische, S | 1 |
| Watras, J | 1 |
| Wideł, M | 1 |
| Suwiński, J | 1 |
| Lee, DJ | 1 |
| Wharam, MD | 1 |
| Kashima, H | 1 |
| Order, SE | 1 |
| Lawson, VG | 1 |
| Rider, WD | 1 |
| Peters, LJ | 1 |
| Urtasun, RC | 1 |
| Chapman, JD | 1 |
| Band, P | 1 |
| Rabin, HR | 1 |
| Fryer, CG | 1 |
| Sturmwind, J | 1 |
| Krashevskiĭ, SV | 1 |
| Loenko, IuN | 1 |
| Polushin, OG | 1 |
| Ustinskov, VI | 1 |
| Isaev, IG | 2 |
| Goldobenko, GV | 1 |
| Tkachev, SI | 1 |
| Khanna, AK | 1 |
| Khanna, A | 1 |
| Asthana, AK | 1 |
| Zolkiver, KI | 1 |
| Muchambetova, GA | 1 |
| Toktamysova, ZS | 1 |
| Beĭbutov, ShM | 1 |
| Zazovskiĭ, LM | 1 |
| Aĭsarova, AM | 1 |
| Musapirova, NA | 1 |
| Shibanova, AI | 1 |
| Rismukhamedova, RS | 1 |
| Rudakov, NP | 1 |
| Kindzel'skiĭ, LP | 1 |
| Zlochevskaia, LL | 1 |
| Andreev, VG | 1 |
| Heinz, KP | 1 |
| Okawa, T | 1 |
| Takahashi, S | 1 |
| Wingate, MB | 1 |
| Cornes, JS | 1 |
4 reviews available for metronidazole and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Managing tissue necrosis associated with oral carcinoma.
Topics: Aged; Anti-Infective Agents; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Mouth Neoplasm | 2004 |
A palliative approach to the management of malodour from malignant fungating tumours.
Topics: Adult; Anti-Infective Agents; Anus Neoplasms; Attitude to Health; Bandages; Carcinoma, Squamous Cell | 2007 |
[Anerobic infections in otolaryngology (author's transl)].
Topics: Adult; Anaerobiosis; Bacteria; Bacterial Infections; Carcinoma, Squamous Cell; Cephalosporins; Chron | 1981 |
Radiosensitizers in the treatment of squamous cell carcinoma of the head and neck.
Topics: Animals; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Hypoxia; | 1977 |
4 trials available for metronidazole and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Glycididazole sodium combined with radiochemotherapy for locally advanced nasopharyngeal carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Case-Control Studies; Chem | 2014 |
Safety and radiation-enhancing effect of sodium glycididazole in locoregionally advanced laryngeal cancers previously treated with platinum-containing chemotherapy regimens: A preliminary report.
Topics: Carcinoma, Squamous Cell; Female; Humans; Laryngeal Neoplasms; Male; Metronidazole; Middle Aged; Nau | 2010 |
Doxorubicin plus metronidazole in the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous | 1993 |
Empiric vaginal metronidazole in the management of the ASCUS Papanicolaou smear: a randomized controlled trial.
Topics: Administration, Intravaginal; Adolescent; Adult; Anti-Infective Agents; Carcinoma, Squamous Cell; Ce | 2002 |
28 other studies available for metronidazole and Carcinoma, Epidermoid
| Article | Year |
|---|---|
The first Clostridium difficile ribotype 027 strain isolated in Taiwan.
Topics: Aged; Anti-Bacterial Agents; Carcinoma, Squamous Cell; Chemoradiotherapy; Clostridioides difficile; | 2016 |
Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models.
Topics: Animals; Azides; Carcinoma, Squamous Cell; CHO Cells; Cricetinae; Cricetulus; Fibrosarcoma; Fructose | 2003 |
CARCINOMA IN SITU OF THE CERVIX.
Topics: Carcinoma in Situ; Carcinoma, Squamous Cell; Cytodiagnosis; Female; Fluorescent Antibody Technique; | 1964 |
Effect of the hypoxic cell sensitizer isometronidazole on local control of two human squamous cell carcinomas after fractionated irradiation.
Topics: Animals; Carcinoma, Squamous Cell; Dose Fractionation, Radiation; Female; Humans; Hypopharyngeal Neo | 2004 |
Experimental model for combination chemotherapy with metronidazole using human uterine cervical carcinomas transplanted into nude mice.
Topics: Animals; Bleomycin; Carcinoma, Squamous Cell; Disease Models, Animal; Drug Therapy, Combination; Fem | 1980 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
[Radiation treatment with metronidazole in patients with oral mucosa cancer in the late stages].
Topics: Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Gamma Rays; Humans; Male; Metroni | 1983 |
[Cell kinetics of oral cancer during gamma teletherapy in combination with the administration of metronidazole].
Topics: Administration, Oral; Adult; Carcinoma, Squamous Cell; Cell Division; Humans; Metronidazole; Middle | 1983 |
Metronidazole and interstitial implantation in the treatment of extensive recurrent head and neck cancers.
Topics: Brachytherapy; Carcinoma, Squamous Cell; Drug Administration Schedule; Humans; Metronidazole; Middle | 1981 |
Response of the solid Guerin epitheliomas of rats to fractionated irradiation and a new 4-nitroimidazole.
Topics: Animals; Carcinoma, Squamous Cell; Male; Metronidazole; Neoplasm Transplantation; Neoplasms, Experim | 1979 |
Short course high fractional dose irradiation in advanced and recurrent head and neck cancer.
Topics: Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Metronidazole; Mucous Membr | 1979 |
Carcinoma of the lip--a case presentation.
Topics: Carcinoma, Squamous Cell; Humans; Lip Neoplasms; Male; Metronidazole; Middle Aged; Radiation Toleran | 1978 |
Modification of the radiocurability of a syngeneic murine squamous carcinoma by its site of growth, by electron-affinic drugs, and by ICRF 159.
Topics: Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Radiation; Female; Imidazoles; Metron | 1976 |
Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells.
Topics: Brain Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Mediasti | 1975 |
[Radiation pathomorphosis of experimental squamous cell cancer during mono- and polyradiomodifications].
Topics: Animals; Blood Glucose; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Gamma Rays; Glu | 1990 |
[Probit analysis in assessing the results of radiation therapy of disseminated cancer of the tongue and floor of the mouth].
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Dose-Response Relationship, Radiation; Female; | 1990 |
[Prognosis and results of radiotherapy of esophageal cancer with the use of radiomodifiers].
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Esophageal Neoplasms; Female; Humans; Hyperther | 1989 |
Postirradiation ulcer and topical metronidazole.
Topics: Breast Neoplasms; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Middle Aged; Radiation In | 1988 |
[Metronidazole in radiotherapy of squamous cell carcinoma of the lung].
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Lung Neoplasms; Male; Metronida | 1986 |
[Radiotherapy of esophageal cancer using local hyperthermia and metronidazole (polyradiomodification)].
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Esophageal Neoplasms; Female; Humans; Hyperther | 1986 |
[Use of the indicators of the proliferative activity of tumors of the oropharyngeal area as qualitative prognostic criteria of the radiotherapy].
Topics: Brachytherapy; Carcinoma, Squamous Cell; Humans; Hyperbaric Oxygenation; Metronidazole; Mouth Neopla | 1986 |
[Radiotherapy, using metronidazole, of regional lymph node metastases of cancer of the oral mucosa].
Topics: Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Lymphatic Metastasis; Mal | 1986 |
[Pathomorphosis of cervical cancer with different methods of radiation treatment].
Topics: Adenocarcinoma; Brachytherapy; Carcinoma, Squamous Cell; Combined Modality Therapy; Evaluation Studi | 1986 |
[Effect of metronidazole on the radiosensitivity of Guerin's carcinoma during its growth].
Topics: Animals; Carcinoma, Squamous Cell; Combined Modality Therapy; Metronidazole; Neoplasm Transplantatio | 1985 |
[Combined (radiation and surgical) treatment of laryngeal cancer patients using metronidazole].
Topics: Adult; Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Humans; Laryngeal Neoplasms; Laryn | 1985 |
Amoebic infection of the female genital tract. A report of three cases.
Topics: Adult; Amebiasis; Carcinoma, Squamous Cell; Entamoeba histolytica; Female; Humans; Metronidazole; Mi | 1973 |
[Elimination of offensive odors by using metronidazole-effect on tamponade during radium irradiation of uterine cancer].
Topics: Adult; Aged; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Middle Aged; Odorants; Radium; | 1968 |
Carcinoma in situ in a young primigravida.
Topics: Adult; Biopsy; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complic | 1965 |