metronidazole has been researched along with Leishmaniasis in 19 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Leishmaniasis: A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the efficacy of enrofloxacin, alone or combined with metronidazole, against Leishmania infantum." | 5.32 | The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis. ( Bianciardi, P; Fasanella, A; Foglia Manzillo, V; Gradoni, L; Oliva, G; Pagano, A; Sorino, S; Trotta, T, 2004) |
| "Treatment with metronidazole was followed by resolution of the skin lesions in one month." | 5.25 | Metronidazole therapy for cutaneous leishmaniasis. ( Pedersen, JK; Sawicki, S, 1975) |
| "Metronidazole has been claimed in several earlier reports to be active in human cases of leishmaniasis and trypanosomiasis." | 3.66 | Inefficacy of metronidazole in experimental infections of Leishmania donovani, L. mexicana, and Trypanosoma brucei brucei. ( Keithly, JS; Langreth, SG, 1983) |
| "A case of cutaneous leishmaniasis, which was successfully treated with metronidazole, is reported from Western Australia." | 3.66 | Cutaneous leishmaniasis in Western Australia. ( Jones, HI, 1979) |
| "We evaluated the efficacy of enrofloxacin, alone or combined with metronidazole, against Leishmania infantum." | 1.32 | The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis. ( Bianciardi, P; Fasanella, A; Foglia Manzillo, V; Gradoni, L; Oliva, G; Pagano, A; Sorino, S; Trotta, T, 2004) |
| "Muco-cutaneous leishmaniasis is now more frequently observed in France owing to population movements." | 1.25 | [Various clinical aspects of cutaneous leishmaniasis, a disease too often unrecognized in the Paris area. Diagnostic and therapeutic problems]. ( Chastanet, B; Lapierre, J; Piguet, B, 1975) |
| "Treatment with metronidazole was followed by resolution of the skin lesions in one month." | 1.25 | Metronidazole therapy for cutaneous leishmaniasis. ( Pedersen, JK; Sawicki, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (84.21) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pennisi, MG | 1 |
| Lo Giudice, S | 1 |
| Masucci, M | 1 |
| De Majo, M | 1 |
| Reale, S | 1 |
| Vitale, F | 1 |
| Bergquist, R | 1 |
| Bianciardi, P | 1 |
| Fasanella, A | 1 |
| Foglia Manzillo, V | 1 |
| Trotta, T | 1 |
| Pagano, A | 1 |
| Sorino, S | 1 |
| Gradoni, L | 1 |
| Oliva, G | 1 |
| Keithly, JS | 1 |
| Langreth, SG | 1 |
| Missoni, E | 1 |
| Lapierre, J | 1 |
| Piguet, B | 1 |
| Chastanet, B | 1 |
| Smit, AM | 1 |
| van der Kaay, HJ | 1 |
| Bjorvatn, B | 1 |
| Neva, FA | 1 |
| Jones, HI | 1 |
| Fossati, C | 1 |
| Wahba, A | 1 |
| Cohen, C | 1 |
| Griffiths, WA | 1 |
| Pedersen, JK | 1 |
| Sawicki, S | 1 |
| Chong, H | 1 |
| Kotłowski, A | 1 |
| Makled, M | 1 |
| Rifaat, M | 1 |
| Azab, M | 1 |
| Makhlouf, S | 1 |
| El-Missery, A | 1 |
| Khalil, N | 1 |
| Long, PI | 1 |
| Radermecker, M | 1 |
| Bekhti, A | 1 |
| Poncelet, E | 1 |
| Salmon, J | 1 |
| Woodruff, AW | 1 |
3 reviews available for metronidazole and Leishmaniasis
| Article | Year |
|---|---|
Parasitic infections affecting the oral cavity.
Topics: Animals; Antiparasitic Agents; Entamoeba; Humans; Leishmaniasis; Metronidazole; Mouth Diseases; Para | 2009 |
[Treatment of intestinal parasitosis].
Topics: Amphotericin B; Anthelmintics; Bithionol; Cestode Infections; Chloroquine; Humans; Intestinal Diseas | 1975 |
Oriental sore. A look at trends in and approaches to the treatment of leishmaniasis.
Topics: Allopurinol; Aminoquinolines; Antimony; Antimony Sodium Gluconate; Cryosurgery; Humans; Leishmaniasi | 1986 |
1 trial available for metronidazole and Leishmaniasis
| Article | Year |
|---|---|
Clinical efficacy of two different drug combinations for the treatment of canine leishmaniasis.
Topics: Animals; Antibodies, Protozoan; Antiprotozoal Agents; Dog Diseases; Dogs; Drug Therapy, Combination; | 2008 |
15 other studies available for metronidazole and Leishmaniasis
| Article | Year |
|---|---|
The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis.
Topics: Animals; Anti-Infective Agents; Dog Diseases; Dogs; Drug Therapy, Combination; Enrofloxacin; Female; | 2004 |
Inefficacy of metronidazole in experimental infections of Leishmania donovani, L. mexicana, and Trypanosoma brucei brucei.
Topics: Animals; Antimony Sodium Gluconate; Cricetinae; Leishmaniasis; Leishmaniasis, Visceral; Mesocricetus | 1983 |
Local treatment of cutaneous leishmaniasis.
Topics: Administration, Topical; Humans; Leishmaniasis; Metronidazole | 1984 |
[Various clinical aspects of cutaneous leishmaniasis, a disease too often unrecognized in the Paris area. Diagnostic and therapeutic problems].
Topics: Adult; Africa, Central; Algeria; Antimony; Child; Child, Preschool; Female; Humans; Leishmania; Leis | 1975 |
Cutaneous leishmaniasis [proceedings].
Topics: Antimony; Antimony Sodium Gluconate; Humans; Leishmaniasis; Leishmaniasis, Mucocutaneous; Metronidaz | 1977 |
Experimental therapy of mice infected with Leishmania tropica.
Topics: Aminoquinolines; Amphotericin B; Animals; Antimony Sodium Gluconate; Disease Models, Animal; Female; | 1979 |
Cutaneous leishmaniasis in Western Australia.
Topics: Adult; Australia; Female; Humans; Leishmaniasis; Metronidazole | 1979 |
Cutaneous leishmaniasis: inefficacity of treatment with metronidazole.
Topics: Antiparasitic Agents; Humans; Leishmaniasis; Metronidazole | 1977 |
Use of metronidazole in cutaneous leishmaniasis.
Topics: Humans; Leishmaniasis; Metronidazole; Rifampin | 1976 |
Metronidazole therapy for cutaneous leishmaniasis.
Topics: Adult; Humans; Leishmaniasis; Male; Metronidazole | 1975 |
[Cutaneous leishmaniasis in the light of personal observations with regard to its diagnosis and treatment in tropical countries].
Topics: Combined Modality Therapy; Cryotherapy; Humans; Iraq; Leishmaniasis; Metronidazole; Pyrimethamine; T | 1988 |
Determination of healing response by immunostimulant therapy (levamisole) in cutaneous leishmaniasis.
Topics: Adult; B-Lymphocytes; Drug Therapy, Combination; Female; Humans; Immunoglobulin G; Immunoglobulin M; | 1987 |
Cutaneous leishmaniasis treated with metronidazole.
Topics: Adult; Evaluation Studies as Topic; Humans; Leishmaniasis; Male; Metronidazole; Remission, Spontaneo | 1973 |
Serum IgE levels in protozoal and helminthic infections.
Topics: Adolescent; Adult; Amebiasis; Ascariasis; Child; Child, Preschool; Echinococcosis; Female; Filariasi | 1974 |
Current practice in tropical medicine.
Topics: Acute Kidney Injury; Amebiasis; Amebicides; Chloroquine; Cholera; Drug Resistance, Microbial; Hepati | 1969 |