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metronidazole and Leishmaniasis

metronidazole has been researched along with Leishmaniasis in 19 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Leishmaniasis: A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).

Research Excerpts

ExcerptRelevanceReference
"We evaluated the efficacy of enrofloxacin, alone or combined with metronidazole, against Leishmania infantum."5.32The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis. ( Bianciardi, P; Fasanella, A; Foglia Manzillo, V; Gradoni, L; Oliva, G; Pagano, A; Sorino, S; Trotta, T, 2004)
"Treatment with metronidazole was followed by resolution of the skin lesions in one month."5.25Metronidazole therapy for cutaneous leishmaniasis. ( Pedersen, JK; Sawicki, S, 1975)
"Metronidazole has been claimed in several earlier reports to be active in human cases of leishmaniasis and trypanosomiasis."3.66Inefficacy of metronidazole in experimental infections of Leishmania donovani, L. mexicana, and Trypanosoma brucei brucei. ( Keithly, JS; Langreth, SG, 1983)
"A case of cutaneous leishmaniasis, which was successfully treated with metronidazole, is reported from Western Australia."3.66Cutaneous leishmaniasis in Western Australia. ( Jones, HI, 1979)
"We evaluated the efficacy of enrofloxacin, alone or combined with metronidazole, against Leishmania infantum."1.32The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis. ( Bianciardi, P; Fasanella, A; Foglia Manzillo, V; Gradoni, L; Oliva, G; Pagano, A; Sorino, S; Trotta, T, 2004)
"Muco-cutaneous leishmaniasis is now more frequently observed in France owing to population movements."1.25[Various clinical aspects of cutaneous leishmaniasis, a disease too often unrecognized in the Paris area. Diagnostic and therapeutic problems]. ( Chastanet, B; Lapierre, J; Piguet, B, 1975)
"Treatment with metronidazole was followed by resolution of the skin lesions in one month."1.25Metronidazole therapy for cutaneous leishmaniasis. ( Pedersen, JK; Sawicki, S, 1975)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199016 (84.21)18.7374
1990's0 (0.00)18.2507
2000's3 (15.79)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pennisi, MG1
Lo Giudice, S1
Masucci, M1
De Majo, M1
Reale, S1
Vitale, F1
Bergquist, R1
Bianciardi, P1
Fasanella, A1
Foglia Manzillo, V1
Trotta, T1
Pagano, A1
Sorino, S1
Gradoni, L1
Oliva, G1
Keithly, JS1
Langreth, SG1
Missoni, E1
Lapierre, J1
Piguet, B1
Chastanet, B1
Smit, AM1
van der Kaay, HJ1
Bjorvatn, B1
Neva, FA1
Jones, HI1
Fossati, C1
Wahba, A1
Cohen, C1
Griffiths, WA1
Pedersen, JK1
Sawicki, S1
Chong, H1
Kotłowski, A1
Makled, M1
Rifaat, M1
Azab, M1
Makhlouf, S1
El-Missery, A1
Khalil, N1
Long, PI1
Radermecker, M1
Bekhti, A1
Poncelet, E1
Salmon, J1
Woodruff, AW1

Reviews

3 reviews available for metronidazole and Leishmaniasis

ArticleYear
Parasitic infections affecting the oral cavity.
    Periodontology 2000, 2009, Volume: 49

    Topics: Animals; Antiparasitic Agents; Entamoeba; Humans; Leishmaniasis; Metronidazole; Mouth Diseases; Para

2009
[Treatment of intestinal parasitosis].
    La Clinica terapeutica, 1975, Oct-15, Volume: 75, Issue:1

    Topics: Amphotericin B; Anthelmintics; Bithionol; Cestode Infections; Chloroquine; Humans; Intestinal Diseas

1975
Oriental sore. A look at trends in and approaches to the treatment of leishmaniasis.
    International journal of dermatology, 1986, Volume: 25, Issue:10

    Topics: Allopurinol; Aminoquinolines; Antimony; Antimony Sodium Gluconate; Cryosurgery; Humans; Leishmaniasi

1986

Trials

1 trial available for metronidazole and Leishmaniasis

ArticleYear
Clinical efficacy of two different drug combinations for the treatment of canine leishmaniasis.
    Veterinary research communications, 2008, Volume: 32 Suppl 1

    Topics: Animals; Antibodies, Protozoan; Antiprotozoal Agents; Dog Diseases; Dogs; Drug Therapy, Combination;

2008

Other Studies

15 other studies available for metronidazole and Leishmaniasis

ArticleYear
The efficacy of enrofloxacin, alone or combined with metronidazole, in the therapy of canine leishmaniasis.
    Parasitology research, 2004, Volume: 93, Issue:6

    Topics: Animals; Anti-Infective Agents; Dog Diseases; Dogs; Drug Therapy, Combination; Enrofloxacin; Female;

2004
Inefficacy of metronidazole in experimental infections of Leishmania donovani, L. mexicana, and Trypanosoma brucei brucei.
    The American journal of tropical medicine and hygiene, 1983, Volume: 32, Issue:3

    Topics: Animals; Antimony Sodium Gluconate; Cricetinae; Leishmaniasis; Leishmaniasis, Visceral; Mesocricetus

1983
Local treatment of cutaneous leishmaniasis.
    Tropical doctor, 1984, Volume: 14, Issue:2

    Topics: Administration, Topical; Humans; Leishmaniasis; Metronidazole

1984
[Various clinical aspects of cutaneous leishmaniasis, a disease too often unrecognized in the Paris area. Diagnostic and therapeutic problems].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1975, Feb-14, Volume: 51, Issue:8

    Topics: Adult; Africa, Central; Algeria; Antimony; Child; Child, Preschool; Female; Humans; Leishmania; Leis

1975
Cutaneous leishmaniasis [proceedings].
    Dermatologica, 1977, Volume: 154, Issue:1

    Topics: Antimony; Antimony Sodium Gluconate; Humans; Leishmaniasis; Leishmaniasis, Mucocutaneous; Metronidaz

1977
Experimental therapy of mice infected with Leishmania tropica.
    The American journal of tropical medicine and hygiene, 1979, Volume: 28, Issue:3

    Topics: Aminoquinolines; Amphotericin B; Animals; Antimony Sodium Gluconate; Disease Models, Animal; Female;

1979
Cutaneous leishmaniasis in Western Australia.
    The Medical journal of Australia, 1979, Nov-03, Volume: 2, Issue:9

    Topics: Adult; Australia; Female; Humans; Leishmaniasis; Metronidazole

1979
Cutaneous leishmaniasis: inefficacity of treatment with metronidazole.
    Archives of dermatology, 1977, Volume: 113, Issue:9

    Topics: Antiparasitic Agents; Humans; Leishmaniasis; Metronidazole

1977
Use of metronidazole in cutaneous leishmaniasis.
    Archives of dermatology, 1976, Volume: 112, Issue:12

    Topics: Humans; Leishmaniasis; Metronidazole; Rifampin

1976
Metronidazole therapy for cutaneous leishmaniasis.
    Archives of dermatology, 1975, Volume: 111, Issue:10

    Topics: Adult; Humans; Leishmaniasis; Male; Metronidazole

1975
[Cutaneous leishmaniasis in the light of personal observations with regard to its diagnosis and treatment in tropical countries].
    Wiadomosci parazytologiczne, 1988, Volume: 34, Issue:4-6

    Topics: Combined Modality Therapy; Cryotherapy; Humans; Iraq; Leishmaniasis; Metronidazole; Pyrimethamine; T

1988
Determination of healing response by immunostimulant therapy (levamisole) in cutaneous leishmaniasis.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl

    Topics: Adult; B-Lymphocytes; Drug Therapy, Combination; Female; Humans; Immunoglobulin G; Immunoglobulin M;

1987
Cutaneous leishmaniasis treated with metronidazole.
    JAMA, 1973, Mar-19, Volume: 223, Issue:12

    Topics: Adult; Evaluation Studies as Topic; Humans; Leishmaniasis; Male; Metronidazole; Remission, Spontaneo

1973
Serum IgE levels in protozoal and helminthic infections.
    International archives of allergy and applied immunology, 1974, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Amebiasis; Ascariasis; Child; Child, Preschool; Echinococcosis; Female; Filariasi

1974
Current practice in tropical medicine.
    Transactions of the Medical Society of London, 1969, Volume: 85

    Topics: Acute Kidney Injury; Amebiasis; Amebicides; Chloroquine; Cholera; Drug Resistance, Microbial; Hepati

1969