metronidazole has been researched along with Exposure, Dental Pulp in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Apical periodontitis was induced in 20 upper and lower premolars of 2 dogs." | 1.39 | Histologic characterization of engineered tissues in the canal space of closed-apex teeth with apical periodontitis. ( Cintra, LT; Dezan, E; Duarte, PC; Ervolino, E; Gomes-Filho, JE; Lodi, CS; Mogami Bomfim, SR; Mota da Silva Santos, L; Penha De Oliveira, SH; Xavier Abimussi, CJ, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gomes-Filho, JE | 1 |
| Duarte, PC | 1 |
| Ervolino, E | 1 |
| Mogami Bomfim, SR | 1 |
| Xavier Abimussi, CJ | 1 |
| Mota da Silva Santos, L | 1 |
| Lodi, CS | 1 |
| Penha De Oliveira, SH | 1 |
| Dezan, E | 1 |
| Cintra, LT | 1 |
| Saoud, TM | 1 |
| Zaazou, A | 1 |
| Nabil, A | 1 |
| Moussa, S | 1 |
| Lin, LM | 1 |
| Gibbs, JL | 1 |
| Asl Aminabadi, N | 1 |
| Satrab, S | 1 |
| Najafpour, E | 1 |
| Samiei, M | 1 |
| Jamali, Z | 1 |
| Shirazi, S | 1 |
| Trairatvorakul, C | 1 |
| Detsomboonrat, P | 1 |
| Yoshiba, K | 1 |
| Yoshiba, N | 1 |
| Iwaku, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparative Study Between Pulp Revascularization and MTA Apexification in Necrotic Immature Anterior Teeth, A Randomized Controlled Trial[NCT03083015] | 66 participants (Actual) | Interventional | 2012-12-06 | Completed | |||
| Outcome of Regenerative Endodontic Procedures for Necrotic Immature Permanent Teeth, Using Two Different Protocols: A Prospective Randomized Clinical Study.[NCT05612451] | 45 participants (Actual) | Interventional | 2018-03-20 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Exposure, Dental Pulp
| Article | Year |
|---|---|
A randomized trial of direct pulp capping in primary molars using MTA compared to 3Mixtatin: a novel pulp capping biomaterial.
Topics: Aluminum Compounds; Anti-Bacterial Agents; Biocompatible Materials; Calcium Compounds; Chi-Square Di | 2016 |
4 other studies available for metronidazole and Exposure, Dental Pulp
| Article | Year |
|---|---|
Histologic characterization of engineered tissues in the canal space of closed-apex teeth with apical periodontitis.
Topics: Animals; Anti-Bacterial Agents; Bicuspid; Blood Coagulation; Bone and Bones; Bone Marrow Cells; Cipr | 2013 |
Clinical and radiographic outcomes of traumatized immature permanent necrotic teeth after revascularization/revitalization therapy.
Topics: Anti-Bacterial Agents; Apexification; Blood Coagulation; Child; Ciprofloxacin; Cohort Studies; Denta | 2014 |
Clinical and radiographic outcomes of traumatized immature permanent necrotic teeth after revascularization/revitalization therapy.
Topics: Anti-Bacterial Agents; Apexification; Blood Coagulation; Child; Ciprofloxacin; Cohort Studies; Denta | 2014 |
Clinical and radiographic outcomes of traumatized immature permanent necrotic teeth after revascularization/revitalization therapy.
Topics: Anti-Bacterial Agents; Apexification; Blood Coagulation; Child; Ciprofloxacin; Cohort Studies; Denta | 2014 |
Clinical and radiographic outcomes of traumatized immature permanent necrotic teeth after revascularization/revitalization therapy.
Topics: Anti-Bacterial Agents; Apexification; Blood Coagulation; Child; Ciprofloxacin; Cohort Studies; Denta | 2014 |
Success rates of a mixture of ciprofloxacin, metronidazole, and minocycline antibiotics used in the non-instrumentation endodontic treatment of mandibular primary molars with carious pulpal involvement.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bisphenol A-Glycidyl Methacrylate; Child; Child, Presc | 2012 |
Effects of antibacterial capping agents on dental pulps of monkeys mechanically exposed to oral microflora.
Topics: Animals; Calcium Hydroxide; Calcium Phosphates; Cefaclor; Ciprofloxacin; Dental Pulp Capping; Dental | 1995 |