Page last updated: 2024-10-31

metronidazole and Spinal Diseases

metronidazole has been researched along with Spinal Diseases in 3 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Spinal Diseases: Diseases involving the SPINE.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Englert, C1
Aebert, H1
Lenhart, M1
Solleder, A1
Nerlich, M1
Neumann, C1
Martin, MJ1
Lee, PY1
Bilgrami, S1
Pesanti, EL1
Singh, NT1
Cobb, RJ1
Chen, LL1
Synnott, V1

Other Studies

3 other studies available for metronidazole and Spinal Diseases

ArticleYear
Thoracic spondylitis from a mycotic (Streptococcus pneumoniae) aortic aneurysm: a case report.
    Spine, 2004, Sep-01, Volume: 29, Issue:17

    Topics: Aneurysm, Infected; Anti-Bacterial Agents; Aortic Aneurysm, Thoracic; Blood Vessel Prosthesis Implan

2004
Streptococcus mitis causing epidural abscess.
    Postgraduate medical journal, 1995, Volume: 71, Issue:834

    Topics: Abscess; Humans; Male; Metronidazole; Middle Aged; Penicillin G; Spinal Diseases; Streptococcal Infe

1995
Spinal cord compression due to anaerobic vertebral osteomyelitis in a patient with metastatic prostate cancer.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21, Issue:2

    Topics: Aged; Anti-Bacterial Agents; Bacteremia; Bacteroides fragilis; Bacteroides Infections; Humans; Lumba

1995