metronidazole has been researched along with Abortion, Spontaneous in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Abortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A recent clinical recommendation by a guidelines group of the Danish Society of Obstetrics and Gynecology advised against the use of clindamycin for the treatment of bacterial vaginosis in pregnancy to reduce the risk of spontaneous preterm birth based on lack of evidence of efficacy." | 7.85 | The treatment of bacterial vaginosis in pregnancy with clindamycin to reduce the risk of infection-related preterm birth: a response to the Danish Society of Obstetrics and Gynecology guideline group's clinical recommendations. ( Jørgensen, JS; Keelan, JA; Lamont, RF; Larsson, PG, 2017) |
| "After adjustment for potential confounders, use of macro-lides (excluding erythromycin), quinolones, tetracyclines, sulfonamides and metronidazole during early pregnancy was associated with an increased risk of spontaneous abortion." | 3.85 | Use of antibiotics during pregnancy and risk of spontaneous abortion. ( Bérard, A; Muanda, FT; Sheehy, O, 2017) |
| " A recent clinical recommendation by a guidelines group of the Danish Society of Obstetrics and Gynecology advised against the use of clindamycin for the treatment of bacterial vaginosis in pregnancy to reduce the risk of spontaneous preterm birth based on lack of evidence of efficacy." | 3.85 | The treatment of bacterial vaginosis in pregnancy with clindamycin to reduce the risk of infection-related preterm birth: a response to the Danish Society of Obstetrics and Gynecology guideline group's clinical recommendations. ( Jørgensen, JS; Keelan, JA; Lamont, RF; Larsson, PG, 2017) |
| "The primary outcome was pelvic infection within 14 days after surgery." | 2.90 | A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery. ( Acam, J; Ahmed, I; Arulkumaran, S; Bar-Zeev, S; Bhutta, ZA; Bishop, JRB; Chibwana, J; Chirwa, A; Chiudzu, G; Coomarasamy, A; Daniels, J; Desmond, N; Ditai, J; Ekunait, J; Goranitis, I; Gulmezoglu, AM; Hewitt, CA; Ismail, H; Iyaku, M; Lissauer, D; Makiika, JJ; Mataya, R; Mbaruku, G; Mboma, A; Merriel, A; Mhango, C; Middleton, L; Mphasa, C; Mwalwanda, C; Ngalawesa, T; Oladapo, OT; Otim Tom, C; Qureshi, R; Roberts, T; Simon, B; Tambala, T; Taulo, F; Unzia, H; Watts, G; Weeks, A; Wilson, A; Zamora, J, 2019) |
| "The primary outcome is pelvic infection 2 weeks after surgery." | 2.87 | Prophylactic antibiotics to reduce pelvic infection in women having miscarriage surgery - The AIMS (Antibiotics in Miscarriage Surgery) trial: study protocol for a randomized controlled trial. ( Acam, JF; Ahmed, I; Anyango, M; Bishop, J; Chibwana, J; Chirwa, A; Chiudzu, G; Coomarasamy, A; Daniels, J; Desmond, N; Ditai, J; Ekunait, J; Goranitis, I; Gulmezoglu, M; Hewitt, C; Ismail, H; Iyaku, M; Lissauer, D; Mataya, R; Mbaruku, G; Mboma, A; Merriel, A; Mhango, C; Middleton, L; Mphasa, C; Mwalwanda, C; Ngalawesa, T; Oladapo, OT; Qureshi, R; Roberts, T; Simon, B; Tambala, T; Taulo, F; Tom, CO; Uniza, H; Watts, G; Weeks, A; Wilson, A; Zamora, J, 2018) |
| "Bacterial vaginosis is associated with adverse pregnancy outcomes across all gestational ages." | 2.41 | Bacterial vaginosis in pregnancy. ( Ugwumadu, AH, 2002) |
| "Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prelabour rupture of the membranes, chorioamnionitis, postpartum endometritis and preterm labour and delivery." | 1.30 | Bacterial vaginosis: its importance in obstetrics. ( Lamont, RF; Woodrow, N, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ekdahl, L | 1 |
| Eoh, KJ | 1 |
| Thumuluru, KM | 1 |
| Butler-Manuel, SA | 1 |
| Tae Kim, Y | 1 |
| Lönnerfors, C | 1 |
| Falconer, H | 1 |
| Persson, J | 1 |
| Muanda, FT | 1 |
| Sheehy, O | 1 |
| Bérard, A | 1 |
| Lissauer, D | 2 |
| Wilson, A | 2 |
| Daniels, J | 2 |
| Middleton, L | 2 |
| Bishop, J | 1 |
| Hewitt, C | 1 |
| Merriel, A | 2 |
| Weeks, A | 2 |
| Mhango, C | 2 |
| Mataya, R | 2 |
| Taulo, F | 2 |
| Ngalawesa, T | 2 |
| Chirwa, A | 2 |
| Mphasa, C | 2 |
| Tambala, T | 2 |
| Chiudzu, G | 2 |
| Mwalwanda, C | 2 |
| Mboma, A | 2 |
| Qureshi, R | 2 |
| Ahmed, I | 2 |
| Ismail, H | 2 |
| Gulmezoglu, M | 1 |
| Oladapo, OT | 2 |
| Mbaruku, G | 2 |
| Chibwana, J | 2 |
| Watts, G | 2 |
| Simon, B | 2 |
| Ditai, J | 2 |
| Tom, CO | 1 |
| Acam, JF | 1 |
| Ekunait, J | 2 |
| Uniza, H | 1 |
| Iyaku, M | 2 |
| Anyango, M | 1 |
| Zamora, J | 2 |
| Roberts, T | 2 |
| Goranitis, I | 2 |
| Desmond, N | 2 |
| Coomarasamy, A | 2 |
| Hewitt, CA | 1 |
| Bishop, JRB | 1 |
| Otim Tom, C | 1 |
| Acam, J | 1 |
| Unzia, H | 1 |
| Makiika, JJ | 1 |
| Bar-Zeev, S | 1 |
| Arulkumaran, S | 1 |
| Bhutta, ZA | 1 |
| Gulmezoglu, AM | 1 |
| Lamont, RF | 2 |
| Keelan, JA | 1 |
| Larsson, PG | 1 |
| Jørgensen, JS | 2 |
| Heinonen, PK | 1 |
| Leinonen, M | 1 |
| Gini, PC | 1 |
| Chukudebelu, WO | 1 |
| Woodrow, N | 1 |
| Ugwumadu, AH | 1 |
| Jensen, LM | 1 |
| Lidegaard, O | 1 |
| Brinsden, PR | 1 |
| Weber, T | 2 |
| Berget, A | 1 |
| Zawadzki, J | 1 |
| Starzyk, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Effectiveness Clinical Early of Transvaginal and Laparoscopic Approaches for Drainage of Tubo -Ovarian Abscess. Randomized Noninferiority[NCT03166982] | 80 participants (Anticipated) | Interventional | 2016-10-26 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Abortion, Spontaneous
| Article | Year |
|---|---|
Bacterial vaginosis in pregnancy.
Topics: Abortion, Spontaneous; Chorionic Gonadotropin; Cytokines; Female; Humans; Metronidazole; Obstetric L | 2002 |
[Metronidazole and pregnancy].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Female; Fetal Death; Humans; Metronidazole; Preg | 1972 |
2 trials available for metronidazole and Abortion, Spontaneous
| Article | Year |
|---|---|
Prophylactic antibiotics to reduce pelvic infection in women having miscarriage surgery - The AIMS (Antibiotics in Miscarriage Surgery) trial: study protocol for a randomized controlled trial.
Topics: Abortion, Spontaneous; Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Pr | 2018 |
A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery.
Topics: Abortion, Spontaneous; Administration, Oral; Adolescent; Adult; Africa South of the Sahara; Antibiot | 2019 |
8 other studies available for metronidazole and Abortion, Spontaneous
| Article | Year |
|---|---|
A combination of second trimester oral metronidazole and no sexual intercourse during second and third trimester may reduce late miscarriage and premature delivery after fertility sparing radical trachelectomy.
Topics: Abortion, Spontaneous; Coitus; Female; Fertility Preservation; Humans; Metronidazole; Neoplasm Recur | 2021 |
Use of antibiotics during pregnancy and risk of spontaneous abortion.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Bacterial Agents; Case-Control Studies; Cohort Studie | 2017 |
The treatment of bacterial vaginosis in pregnancy with clindamycin to reduce the risk of infection-related preterm birth: a response to the Danish Society of Obstetrics and Gynecology guideline group's clinical recommendations.
Topics: Abortion, Spontaneous; Anti-Bacterial Agents; Clindamycin; Female; Humans; Infant, Low Birth Weight; | 2017 |
Fecundity and morbidity following acute pelvic inflammatory disease treated with doxycycline and metronidazole.
Topics: Abortion, Induced; Abortion, Spontaneous; Adolescent; Adult; Anti-Infective Agents; Bacteroides; Bio | 2003 |
Pelvic abscess in gynecologic patients.
Topics: Abortion, Induced; Abortion, Spontaneous; Abscess; Adolescent; Adult; Anti-Bacterial Agents; Female; | 1981 |
Bacterial vaginosis: its importance in obstetrics.
Topics: Abortion, Spontaneous; Anti-Infective Agents; Chorioamnionitis; Endometritis; Female; Humans; Metron | 1998 |
Spontaneous abortion of one twin with Down's syndrome followed by delivery of the second twin 14 weeks later; a case report.
Topics: Abortion, Spontaneous; Adult; Chorioamnionitis; Diseases in Twins; Down Syndrome; Embryo Transfer; F | 1991 |
[Significance of the treatment of trichomoniasis in gynecology and obstetrics].
Topics: Abortion, Spontaneous; Antiprotozoal Agents; Antitrichomonal Agents; Appendicitis; Female; Humans; M | 1969 |