metronidazole has been researched along with Pain, Postoperative in 23 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Evaluation of the postoperative signs of alveolar osteitis and infection was made by a dental surgeon five days postoperatively." | 7.11 | A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial. ( Al-Samadani, KH; Alharbi, AM; Alsaidalani, HM; Gazal, G; Karbouji, GA, 2022) |
| "No statistically significant difference is observed between both the groups and a combination of Ciprofloxacin, Minocycline and Tinidazole antibacterial drugs can be used on teeth pulpally involved with physiologic root resorption." | 5.16 | In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations. ( Anantharaj, A; Jaya, AR; Praveen, P; Rani, PS; Venkataraghavan, K, 2012) |
| " There is scarce information regarding the prophylactic effects of oral metronidazole on postoperative complications of anal fissure." | 5.13 | A randomized clinical trial on the effect of oral metronidazole on wound healing and pain after anal sphincterotomy and fissurectomy. ( Bolandparvaz, S; Hosseini, SV; Nouri Amirkolaee, M; Sabet, B, 2008) |
| "To compare the effect of metronidazole on post conventional hemorrhoidectomy pain in patients with third and fourth degree hemorrhoids." | 5.12 | Post hemorrhoidectomy pain. A randomized controlled trial. ( Al-Masuod, N; Al-Mulhim, AS; Ali, AM; Alwahidi, A, 2006) |
| "Evaluation of the postoperative signs of alveolar osteitis and infection was made by a dental surgeon five days postoperatively." | 3.11 | A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial. ( Al-Samadani, KH; Alharbi, AM; Alsaidalani, HM; Gazal, G; Karbouji, GA, 2022) |
| "Metronidazole has been shown to decrease postoperative pain but is not used widely." | 2.80 | Efficacy of metronidazole versus placebo in pain control after hemorrhoidectomy. Results of a controlled clinical trial. ( Chávez-Tostado, M; Cortés-Lares, JA; Cuesta-Márquez, LA; Fuentes Orozco, C; García-Rentería, J; González-Ojeda, A; Guerrero-Tarín, JE; Palomares-Chacón, UR; Rendón-Félix, J; Salazar-Parra, M; Solorio-López, S, 2015) |
| "The occurrence of postoperative pain, swelling, trismus, SSI and AO were compared between the groups." | 2.76 | Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study. ( Akadiri, AO; Arotiba, JT; Fasola, OA; Olusanya, AA, 2011) |
| "Oral metronidazole has been previously demonstrated to decrease postoperative pain after open diathermy hemorrhoidectomy." | 2.71 | Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing. ( Armstrong, D; Nicholson, TJ, 2004) |
| "Metronidazole has been shown to reduce pain after open hemorrhoidectomy." | 2.70 | A randomized, double-blind trial of the effect of metronidazole on pain after closed hemorrhoidectomy. ( Balfour, L; Botterill, ID; Burke, DA; Finan, PJ; Sagar, PM; Stojkovic, SG, 2002) |
| "There was no recurrence of the volvulus at 1 to 6 years follow up but 8 patients (9." | 2.68 | Extraperitonealization for sigmoid volvulus: a reappraisal. ( Khanna, AK; Kumar, K; Misra, MK, 1995) |
| "Metronidazole was more effective in pain control than Arnica (p less than 0." | 2.65 | Metronidazole (Flagyl) and Arnica Montana in the prevention of post-surgical complications, a comparative placebo controlled clinical trial. ( Kaziro, GS, 1984) |
| "Metronidazole is a cheap, safe and effective intervention for reducing postoperative pain following conventional haemorrhoidectomy." | 2.55 | Systematic review and meta-analysis of the role of metronidazole in post-haemorrhoidectomy pain relief. ( Charters, P; Cornille, JB; Daniels, IR; Lyons, NJR; Pathak, S; Smart, NJ, 2017) |
| "Metronidazole use was associated with a significantly shorter time to return to normal activities (standardized mean difference, -0." | 2.55 | Systemic Metronidazole May Not Reduce Posthemorrhoidectomy Pain: A Meta-Analysis of Randomized Controlled Trials. ( Coughlin, S; Emmerton-Coughlin, HM; Foley, N; Vinden, C; Wanis, KN, 2017) |
| "Day-case rate, postoperative pain (measured by a visual analogic scale, 1-10), admissions, re-admissions, early postoperative situation and recurrence were evaluated in the study." | 1.38 | Day case stapled anopexy for the treatment of haemorrhoids and rectal mucosal prolapse. ( Carbonell Roure, J; Estrada Ferrer, O; García Torralbo, E; Heredia Budó, A; Hidalgo Grau, LA; Llorca Cardeñosa, S; Suñol Sala, X, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Gazal, G | 1 |
| Al-Samadani, KH | 1 |
| Alsaidalani, HM | 1 |
| Karbouji, GA | 1 |
| Alharbi, AM | 1 |
| Wilkie, BD | 1 |
| Chandra, R | 1 |
| Chua, J | 1 |
| Lam, DCS | 1 |
| Paratz, ED | 1 |
| An, V | 1 |
| Keck, JO | 1 |
| Gao, H | 1 |
| Cheng, X | 1 |
| Liu, R | 1 |
| Wang, X | 1 |
| Wang, W | 1 |
| Gong, F | 1 |
| Pan, R | 1 |
| Hu, J | 1 |
| Rabelo, FEF | 1 |
| Lacerda-Filho, A | 1 |
| Mansur, ES | 1 |
| de Oliveira, FH | 1 |
| de Queiroz, FL | 1 |
| França-Neto, PR | 1 |
| Misson, N | 1 |
| Lyons, NJR | 1 |
| Cornille, JB | 1 |
| Pathak, S | 1 |
| Charters, P | 1 |
| Daniels, IR | 1 |
| Smart, NJ | 1 |
| Li, HZ | 1 |
| Cheng, YS | 1 |
| Liu, XF | 1 |
| Zhu, XN | 1 |
| Xia, W | 1 |
| Manning, JPR | 1 |
| Barazanchi, AWH | 1 |
| Su'a, B | 1 |
| Hill, AG | 1 |
| Jaya, AR | 1 |
| Praveen, P | 1 |
| Anantharaj, A | 1 |
| Venkataraghavan, K | 1 |
| Rani, PS | 1 |
| Solorio-López, S | 1 |
| Palomares-Chacón, UR | 1 |
| Guerrero-Tarín, JE | 1 |
| González-Ojeda, A | 1 |
| Cortés-Lares, JA | 1 |
| Rendón-Félix, J | 1 |
| García-Rentería, J | 1 |
| Chávez-Tostado, M | 1 |
| Cuesta-Márquez, LA | 1 |
| Salazar-Parra, M | 1 |
| Fuentes Orozco, C | 1 |
| Wanis, KN | 1 |
| Emmerton-Coughlin, HM | 1 |
| Coughlin, S | 1 |
| Foley, N | 1 |
| Vinden, C | 1 |
| Hosseini, SV | 1 |
| Sabet, B | 1 |
| Nouri Amirkolaee, M | 1 |
| Bolandparvaz, S | 1 |
| Olusanya, AA | 1 |
| Arotiba, JT | 1 |
| Fasola, OA | 1 |
| Akadiri, AO | 1 |
| Hidalgo Grau, LA | 1 |
| Heredia Budó, A | 1 |
| Llorca Cardeñosa, S | 1 |
| Carbonell Roure, J | 1 |
| Estrada Ferrer, O | 1 |
| García Torralbo, E | 1 |
| Suñol Sala, X | 1 |
| Balfour, L | 1 |
| Stojkovic, SG | 1 |
| Botterill, ID | 1 |
| Burke, DA | 1 |
| Finan, PJ | 1 |
| Sagar, PM | 1 |
| La Torre, F | 1 |
| Nicolai, AP | 1 |
| Nicholson, TJ | 1 |
| Armstrong, D | 1 |
| Al-Mulhim, AS | 1 |
| Ali, AM | 1 |
| Al-Masuod, N | 1 |
| Alwahidi, A | 1 |
| Uraiqat, A | 1 |
| Ala, S | 1 |
| Saeedi, M | 1 |
| Eshghi, F | 1 |
| Mirzabeygi, P | 1 |
| Kaziro, GS | 1 |
| Khanna, AK | 1 |
| Misra, MK | 1 |
| Kumar, K | 1 |
| Carapeti, EA | 1 |
| Kamm, MA | 1 |
| McDonald, PJ | 1 |
| Phillips, RK | 1 |
| Lyall, JB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomised, Double-blind, Placebo-controlled, Parallel-group, Multicentre, Interventional Clinical Trial to Assess the Efficacy and Safety of the Food Supplement Microsmin® Plus in the Symptomatic Treatment of Haemorrhoids[NCT05750563] | 80 participants (Anticipated) | Interventional | 2023-02-28 | Not yet recruiting | |||
| Randomised, Double-blind, Placebo-controlled Trial Evaluating the Effects of Metronidazole Ointment in Facilitating Resolution of Non-healing Pilonidal Sinus Wounds.[NCT04273997] | Phase 2 | 80 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Pain, Postoperative
| Article | Year |
|---|---|
Systematic review and meta-analysis of the role of metronidazole in post-haemorrhoidectomy pain relief.
Topics: Adult; Aged; Analgesics; Female; Hemorrhoidectomy; Hemorrhoids; Humans; Male; Metronidazole; Middle | 2017 |
Metronidazole following excisional haemorrhoidectomy: a systematic review and meta-analysis.
Topics: Anti-Bacterial Agents; Hemorrhoidectomy; Humans; Metronidazole; Pain, Postoperative | 2018 |
Systemic Metronidazole May Not Reduce Posthemorrhoidectomy Pain: A Meta-Analysis of Randomized Controlled Trials.
Topics: Administration, Oral; Analgesics; Anti-Infective Agents; Hemorrhoidectomy; Hemorrhoids; Humans; Metr | 2017 |
16 trials available for metronidazole and Pain, Postoperative
| Article | Year |
|---|---|
A Comparison of Pre-Emptive Co-Amoxiclav, Postoperative Amoxicillin, and Metronidazole for Prevention of Postoperative Complications in Dentoalveolar Surgery: A Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Dry Socket | 2022 |
Efficacy of postoperative oral metronidazole for haemorrhoidectomy pain: a randomized double-blind, placebo-controlled trial.
Topics: Double-Blind Method; Hemorrhoidectomy; Hemorrhoids; Humans; Metronidazole; Pain, Postoperative; Qual | 2021 |
Benefits of flavonoid and metronidazole use after excisional hemorrhoidectomy: a randomized double-blind clinical trial.
Topics: Double-Blind Method; Flavonoids; Hemorrhoidectomy; Hemorrhoids; Humans; Metronidazole; Pain Measurem | 2021 |
In vivo evaluation of lesion sterilization and tissue repair in primary teeth pulp therapy using two antibiotic drug combinations.
Topics: Anti-Bacterial Agents; Child; Ciprofloxacin; Dental Pulp Necrosis; Double-Blind Method; Drug Combina | 2012 |
Efficacy of metronidazole versus placebo in pain control after hemorrhoidectomy. Results of a controlled clinical trial.
Topics: Adult; Aged; Female; Hemorrhoidectomy; Hemorrhoids; Humans; Male; Metronidazole; Middle Aged; Pain M | 2015 |
A randomized clinical trial on the effect of oral metronidazole on wound healing and pain after anal sphincterotomy and fissurectomy.
Topics: Administration, Oral; Adult; Anal Canal; Anti-Infective Agents; Female; Fissure in Ano; Humans; Male | 2008 |
Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study.
Topics: Administration, Oral; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibi | 2011 |
A randomized, double-blind trial of the effect of metronidazole on pain after closed hemorrhoidectomy.
Topics: Analgesics; Double-Blind Method; Female; Hemorrhoids; Humans; Male; Metronidazole; Middle Aged; Pain | 2002 |
Clinical use of micronized purified flavonoid fraction for treatment of symptoms after hemorrhoidectomy: results of a randomized, controlled, clinical trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combinati | 2004 |
Topical metronidazole (10 percent) decreases posthemorrhoidectomy pain and improves healing.
Topics: Administration, Topical; Adult; Analgesics; Hemorrhoids; Humans; Metronidazole; Middle Aged; Pain Me | 2004 |
Post hemorrhoidectomy pain. A randomized controlled trial.
Topics: Adult; Anti-Infective Agents; Antibiotic Prophylaxis; Female; Hemorrhoids; Humans; Male; Metronidazo | 2006 |
Topical metronidazole can reduce pain after surgery and pain on defecation in postoperative hemorrhoidectomy.
Topics: Administration, Topical; Adult; Anti-Infective Agents; Defecation; Digestive System Surgical Procedu | 2008 |
Metronidazole (Flagyl) and Arnica Montana in the prevention of post-surgical complications, a comparative placebo controlled clinical trial.
Topics: Clinical Trials as Topic; Humans; Metronidazole; Molar, Third; Pain, Postoperative; Placebos; Plants | 1984 |
Extraperitonealization for sigmoid volvulus: a reappraisal.
Topics: Adolescent; Adult; Aged; Ampicillin; Colectomy; Drug Therapy, Combination; Elective Surgical Procedu | 1995 |
Double-blind randomised controlled trial of effect of metronidazole on pain after day-case haemorrhoidectomy.
Topics: Ambulatory Surgical Procedures; Analgesics; Double-Blind Method; Female; Hemorrhoids; Humans; Male; | 1998 |
Third molar surgery: the effect of primary closure, wound dressing and metronidazole on postoperative recovery.
Topics: Acetaminophen; Adult; Analgesics; Bandages; Bismuth; Caffeine; Codeine; Drug Combinations; Female; H | 1991 |
4 other studies available for metronidazole and Pain, Postoperative
| Article | Year |
|---|---|
Clinical study of herbal mixture "Diding Oral Medicine" as an alternative to preventative antibiotics in perioperative hemorrhoids: A CARE-compliant article.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefazolin; Drugs, Chines | 2021 |
Metronidazole for Posthemorrhoidectomy Pain: Does No Statistical Significance Mean Insignificant Effect on Pain Relief?
Topics: Hemorrhoids; Humans; Metronidazole; Pain; Pain Management; Pain Measurement; Pain, Postoperative | 2017 |
Day case stapled anopexy for the treatment of haemorrhoids and rectal mucosal prolapse.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Care; Anti-Bacterial Agents; Anti-Infective Agents; Antib | 2012 |
Post hemorrhoidectomy pain. A randomized controlled trial.
Topics: Hemorrhoids; Humans; Length of Stay; Metronidazole; Pain, Postoperative; Randomized Controlled Trial | 2007 |