metronidazole has been researched along with Acute Hypercapnic Respiratory Failure in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "She quickly developed dysphagia and odynophagia with subsequent generalised spasms and profound hypoxic respiratory failure requiring nasotracheal intubation." | 1.51 | Return of the old guard: a case of tetanus in an unvaccinated patient. ( Gega, A; Ibe, U; Jiwa, N; Rehmani, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ibe, U | 1 |
| Rehmani, S | 1 |
| Jiwa, N | 1 |
| Gega, A | 1 |
| Compain, F | 1 |
| Rossi, B | 1 |
| Richaud, C | 1 |
| Guerot, E | 1 |
| Rostane, H | 1 |
| Jarraud, S | 1 |
| Podglajen, I | 1 |
2 other studies available for metronidazole and Acute Hypercapnic Respiratory Failure
| Article | Year |
|---|---|
Return of the old guard: a case of tetanus in an unvaccinated patient.
Topics: Aged; Anti-Bacterial Agents; Deglutition Disorders; Female; Gastrostomy; Humans; Metronidazole; Resp | 2019 |
Photo Quiz: A 44-Year-Old Kidney Transplant Patient with Pneumonia.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; beta-Lactam | 2017 |