metronidazole and Appendicitis studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Appendicitis: Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.

Research Excerpts

Excerpt	Relevance	Reference
"In a 3-year study, 103 children with acute non-perforated appendicitis who underwent appendicectomy were randomized for either a single preoperative dose of gentamicin and metronidazole or three doses of gentamicin and metronidazole given before and after the operation."	10.17	Antibiotic prophylaxis in acute non-perforated appendicitis in children: single dose of metronidazole and gentamicin. ( Saing, H; Tam, PK; Tsang, TM, 1992)
"Among adults with uncomplicated acute appendicitis, treatment with 7 days of oral moxifloxacin compared with 2 days of intravenous ertapenem followed by 5 days of levofloxacin and metronidazole resulted in treatment success rates greater than 65% in both groups, but failed to demonstrate noninferiority for treatment success of oral antibiotics compared with intravenous followed by oral antibiotics."	9.41	Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial. ( Aarnio, M; Grönroos, J; Haijanen, J; Hurme, S; Ilves, I; Laukkarinen, J; Löyttyniemi, E; Marttila, H; Mattila, A; Meriläinen, S; Nordström, P; Paajanen, H; Pinta, T; Rantanen, T; Rautio, T; Rintala, J; Salminen, P; Sävelä, EL; Savolainen, H; Sippola, S; Sippola, T; Tammilehto, V, 2021)
"We aimed to investigate the pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration of the combination of fosfomycin and metronidazole in patients undergoing laparoscopic appendectomy for uncomplicated appendicitis."	9.34	The plasma pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration in patients undergoing appendectomy for uncomplicated appendicitis. ( Arpi, M; Fonnes, S; Holzknecht, BJ; Rosenberg, J; Weisser, JJ, 2020)
" Historically, a 3-drug regimen consisting of ampicillin, gentamicin, and clindamycin (AGC) has been used postoperatively for perforated appendicitis."	9.13	Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial. ( Andrews, WS; Holcomb, GW; Murphy, JP; Ostlie, DJ; Sharp, RJ; Sharp, SW; Snyder, CL; Spilde, TL; St Peter, SD; Tsao, K, 2008)
"To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21."	9.09	Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. ( Banani, SA; Talei, A, 1999)
"The combination of cefepime plus metronidazole is safe and effective therapy for patients with severe intra-abdominal infections."	9.08	A randomized, double-blind clinical trial comparing cefepime plus metronidazole with imipenem-cilastatin in the treatment of complicated intra-abdominal infections. Cefepime Intra-abdominal Infection Study Group. ( Barie, PS; Baumgartner, TF; Dellinger, EP; Rotstein, OD; Solomkin, JS; Vogel, SB; Yang, JY, 1997)
"The efficacy of imipenem-cilastatin was compared with that of tobramycin and metronidazole for the treatment of appendicitis-associated abdominal infections in children in an open, randomized trial."	9.07	Imipenem-cilastatin vs. tobramycin and metronidazole for appendicitis-related infections. ( Heikkinen, E; Seppänen, J; Uhari, M, 1992)
"The safety and efficacy of a single daily dose of netilmicin plus metronidazole after appendicectomy for gangrenous and perforated appendicitis was compared with the traditional thrice daily dosage."	9.06	Once daily administration of netilmicin compared with thrice daily, both in combination with metronidazole, in gangrenous and perforated appendicitis. ( Fan, ST; Lau, KF; Lau, WY; Mauracher, EH; Teoh-Chan, CH, 1988)
"Eighty-four cases of non-perforated appendicitis in children were randomly allocated to receive either oxytetracycline lavage alone or oxytetracycline lavage plus peroperative intravenous metronidazole and cefuroxime."	9.06	Antibiotic prophylaxis in non-perforated appendicitis of childhood: tetracycline lavage compared with peroperative intravenous cefuroxime and metronidazole. ( Carle, G; Davidson, AI; Miller, SS; Reid, TM; Thomson, SR, 1987)
"In severe appendicitis, the effect of a single intravenous dose of metronidazole (500 mg) was compared with cefoxitin (1 g)."	9.05	Metronidazole v. cefoxitin in severe appendicitis--a trial to compare a single intraoperative dose of two antibiotics given intravenously. ( Bates, T; Corder, AP; Donaldson, PJ; Harrison, M; Prior, JE, 1983)
"59 children with gangrenous (n = 11) or perforated (n = 48) appendicitis underwent a prospective, randomized trial and received cefazolin or cefazolin plus metronidazole."	9.05	Metronidazole plus cefazolin versus cefazolin in gangrenous and perforated appendicitis in childhood--a prospective randomised trial. ( Miholić, J; Riezinger, F; Wurnig, P, 1983)
"A study on 42 surgical patients was carried out to find out whether cefuroxime may be substituted for gentamicin in combination with metronidazole in the treatment of peritonitis secondary to perforation of appendix."	9.05	Comparison of cefuroxime and gentamicin in combination with metronidazole in the treatment of peritonitis due to perforation of the appendix. ( Arvilommi, H; Saario, I; Silvola, H, 1983)
"Recent studies are discordant regarding postoperative use of piperacillin/tazobactam (PT) versus ceftriaxone/metronidazole (CM) for pediatric complicated appendicitis."	8.31	Postoperative Antibiotics for Complicated Appendicitis in Children: Piperacillin/Tazobactam Versus Ceftriaxone with Metronidazole. ( Abdullah, F; Alayleh, A; Carter, M; De Boer, C; Goldstein, SD; Hu, A; Linton, S; Pitt, JB; Raval, M; Zeineddin, S, 2023)
"Rates of organ space infection and resource utilization were similar in children with complicated appendicitis treated with ceftriaxone plus metronidazole and piperacillin/tazobactam."	8.12	Ceftriaxone with Metronidazole versus Piperacillin/Tazobactam in the management of complicated appendicitis in children: Results from a multicenter pediatric NSQIP analysis. ( Anandalwar, SP; Graham, DA; Hills-Dunlap, JL; Kashtan, MA; Melvin, P; Rangel, SJ, 2022)
"Ceftriaxone combined with metronidazole is superior to cefoxitin alone in preventing SSIs in children with uncomplicated appendicitis."	8.02	Ceftriaxone Combined With Metronidazole is Superior to Cefoxitin Alone in the Management of Uncomplicated Appendicitis in Children: Results from a Multicenter Collaborative Comparative Effectiveness Study. ( Anandalwar, SP; Cameron, DB; Graham, DA; Hills-Dunlap, JL; Kashtan, MA; Melvin, P; Rangel, SJ, 2021)
"After appendectomy due to complicated acute appendicitis (CAA), there are some alternatives as antibiotic scheme: ciprofloxacin/metronidazole; as well as monoscheme based on carbapenems: ertapenem, meropenem, and imipenem."	7.96	Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population. ( Arevalo-Vidal, E; Baquerizo-Burgos, J; Bunces-Orellana, O; Bustos-Galarza, K; Ferrín-Viteri, M; Oleas, R; Puga-Tejada, M, 2020)
"Metronidazole, 30 mg/kg per dose, once daily achieved AUC target attainment for B fragilis with an MIC of 2 mcg/mL or less in pediatric appendicitis patients."	7.91	Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study. ( Anderson, PL; Chen, X; Child, J; Jones, RN; MacBrayne, C; Mistry, RD; Parker, SK; Somme, S, 2019)
"The aim of this study was to evaluate the efficacy of combined therapy with metronidazole and broad-spectrum antibiotics for patients with perforated appendicitis who underwent surgical intervention."	7.85	The efficacy of combined therapy with metronidazole and broad-spectrum antibiotics on postoperative outcomes for pediatric patients with perforated appendicitis. ( Geng, Q; Guo, C; Shang, Q; Zhang, X, 2017)
"Metronidazole was used for treatment of 212 patients with peritonitis of appendicular origin."	7.67	[Metronidazole in the complex treatment of peritonitis of appendicular etiology in children]. ( Astakhov, AA; Kharchenko, DM; Sleptsov, VP; Slezkin, GA, 1987)
"Children suspected of having appendicitis were treated with preoperative metronidazole per rectum and then postoperative metronidazole per rectum until the drug could be administered orally."	7.66	Pre- and postoperative rectal metronidazole for the prevention of wound infection in childhood appendicitis. ( Ford, WD; MacKellar, A; Richardson, CJ, 1980)
"Sixty-four consecutive patients appendicectomized for perforated appendicitis were studied retrospectively to assess the effect of peroperative metronidazolee on postoperative infections."	7.66	Metronidazole and appendicitis. Can a preoperative prophylaxis be changed to a peroperative treatment in high risk patients? ( Gottrup, F; Saksø, P, 1981)
"Fifty-four consecutive children with performed appendicitis were treated with intravenous and rectal metronidazole combined with another antimicrobial agent."	7.66	Perforated appendicitis in children: use of metronidazole for the reduction of septic complications. ( Guiney, EJ; O'Donnell, B; Puri, P; Rangecroft, L; Zervos, G, 1981)
"Prospective investigation of consecutive children suffering from non-perforating appendicitis indicated that metronidazole prophylaxis significantly reduces the risk of postoperative wound sepsis regardless of the method of closure."	7.66	The influence of metronidazole prophylaxis and the method of closure on wound infection in non-perforating appendicitis in childhood. ( Boston, VE; Buick, RG; McLean, MD, 1983)
"A study comparing the effectiveness of metronidazole and ampicillin in preventing wound infection in gangrenous or perforated appendicitis without general peritonitis was performed."	7.66	Effect of metronidazole and ampicillin on patients with gangrenous or perforated appendicitis. A comparative study. ( Bergan, T; Jakobsen, A; Liavåg, I; Roland, M, 1981)
"In a 3-year study, 103 children with acute non-perforated appendicitis who underwent appendicectomy were randomized for either a single preoperative dose of gentamicin and metronidazole or three doses of gentamicin and metronidazole given before and after the operation."	6.17	Antibiotic prophylaxis in acute non-perforated appendicitis in children: single dose of metronidazole and gentamicin. ( Saing, H; Tam, PK; Tsang, TM, 1992)
"Among adults with uncomplicated acute appendicitis, treatment with 7 days of oral moxifloxacin compared with 2 days of intravenous ertapenem followed by 5 days of levofloxacin and metronidazole resulted in treatment success rates greater than 65% in both groups, but failed to demonstrate noninferiority for treatment success of oral antibiotics compared with intravenous followed by oral antibiotics."	5.41	Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial. ( Aarnio, M; Grönroos, J; Haijanen, J; Hurme, S; Ilves, I; Laukkarinen, J; Löyttyniemi, E; Marttila, H; Mattila, A; Meriläinen, S; Nordström, P; Paajanen, H; Pinta, T; Rantanen, T; Rautio, T; Rintala, J; Salminen, P; Sävelä, EL; Savolainen, H; Sippola, S; Sippola, T; Tammilehto, V, 2021)
"We aimed to investigate the pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration of the combination of fosfomycin and metronidazole in patients undergoing laparoscopic appendectomy for uncomplicated appendicitis."	5.34	The plasma pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration in patients undergoing appendectomy for uncomplicated appendicitis. ( Arpi, M; Fonnes, S; Holzknecht, BJ; Rosenberg, J; Weisser, JJ, 2020)
"Patients aged 5 years or older with uncomplicated appendicitis at 1 US hospital were randomized to appendectomy or intravenous ertapenem greater than or equal to 48 hours and oral cefdinir and metronidazole."	5.24	Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management. ( Amii, R; DeUgarte, DA; Jude, CM; Krishnadasan, A; Moran, GJ; Morim, A; Mower, WR; Pathmarajah, K; Saltzman, DJ; Talan, DA; Wu, JX, 2017)
"A single pre-operative dose of cefuroxime and metronidazole had the same efficacy in preventing surgical site infections in cases of non-perforated appendicitis as when the same regimen was repeated post-operatively."	5.20	Evaluation of postoperative antibiotics after non-perforated appendectomy. ( Jan, H; Khan, A; Khan, MM; Rafiq, MS, 2015)
"In a previous prospective randomized trial, we found a once-a-day regimen of ceftriaxone and metronidazole to be an efficient, cost-effective treatment for children with perforated appendicitis."	5.14	A complete course of intravenous antibiotics vs a combination of intravenous and oral antibiotics for perforated appendicitis in children: a prospective, randomized trial. ( Aguayo, P; Andrews, WS; Fraser, JD; Holcomb, GW; Keckler, SJ; Leys, CM; Murphy, JP; Newland, JG; Ostlie, DJ; Sharp, RJ; Sharp, SW; Snyder, CL; St Peter, SD, 2010)
" Historically, a 3-drug regimen consisting of ampicillin, gentamicin, and clindamycin (AGC) has been used postoperatively for perforated appendicitis."	5.13	Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial. ( Andrews, WS; Holcomb, GW; Murphy, JP; Ostlie, DJ; Sharp, RJ; Sharp, SW; Snyder, CL; Spilde, TL; St Peter, SD; Tsao, K, 2008)
"The incidence of wound infection in patients who underwent surgery for colon disease and acute appendicitis was lower when they were treated with piperacillin-tazobactam (P< ."	5.12	[Controlled, open, parallel-group study of the clinical and microbiological efficacy of piperacillin-tazobactam versus metronidazole + gentamicin in urgent colorectal surgery]. ( Alvarez, G; Bombuy, E; Charco, R; Ferrer, J; Fondevila, C; Fuster, J; García-Valdecasas, JC, 2006)
"In a randomized controlled trial of 269 patients aged 15-70 years with non-perforated appendicitis undergoing open appendicectomy; 92 received single dose preoperative (group A), 94 received three-dose (group B) and 83 received 5-day perioperative (group C) regimens of cefuroxime and metronidazole."	5.11	Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis. ( Chung, SS; Fok, KL; Fung, TM; Lam, YH; Mui, LM; Ng, CS; Ng, EK; Wong, SK, 2005)
"To demonstrate the efficacy of oral metronidazole (OM) in simple or complicated appendicitis with localized peritonitis, a randomized prospective study was carried out in 1083 patients, ranging in age from 4 to 50 years (mean age, 21."	5.09	Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. ( Banani, SA; Talei, A, 1999)
"The combination of cefepime plus metronidazole is safe and effective therapy for patients with severe intra-abdominal infections."	5.08	A randomized, double-blind clinical trial comparing cefepime plus metronidazole with imipenem-cilastatin in the treatment of complicated intra-abdominal infections. Cefepime Intra-abdominal Infection Study Group. ( Barie, PS; Baumgartner, TF; Dellinger, EP; Rotstein, OD; Solomkin, JS; Vogel, SB; Yang, JY, 1997)
"The efficacy of imipenem-cilastatin was compared with that of tobramycin and metronidazole for the treatment of appendicitis-associated abdominal infections in children in an open, randomized trial."	5.07	Imipenem-cilastatin vs. tobramycin and metronidazole for appendicitis-related infections. ( Heikkinen, E; Seppänen, J; Uhari, M, 1992)
"Three hundred and seven patients with appendicitis were randomized to receive cefoxitin or gentamicin and metronidazole."	5.06	Cefoxitin versus gentamicin and metronidazole in prevention of post-appendicectomy sepsis: a randomized, prospective trial. ( Chu, KW; Fan, ST; Lau, WY; Wong, KK; Yeung, C; Yip, WC; Yiu, TF, 1986)
"Eighty-four cases of non-perforated appendicitis in children were randomly allocated to receive either oxytetracycline lavage alone or oxytetracycline lavage plus peroperative intravenous metronidazole and cefuroxime."	5.06	Antibiotic prophylaxis in non-perforated appendicitis of childhood: tetracycline lavage compared with peroperative intravenous cefuroxime and metronidazole. ( Carle, G; Davidson, AI; Miller, SS; Reid, TM; Thomson, SR, 1987)
" Patients with free purulent peritonitis due to perforated appendicitis or colonic perforation were treated with intravenous infusion of cefuroxime and metronidazole."	5.06	A prospective randomized study of continuous peritoneal lavage postoperatively in the treatment of purulent peritonitis. ( Andersson, C; Englund, N; Glise, H; Hallerbäck, B; Nihlberg, A; Solhaug, J; Wahlström, B, 1986)
"59 children with gangrenous (n = 11) or perforated (n = 48) appendicitis underwent a prospective, randomized trial and received cefazolin or cefazolin plus metronidazole."	5.05	Metronidazole plus cefazolin versus cefazolin in gangrenous and perforated appendicitis in childhood--a prospective randomised trial. ( Miholić, J; Riezinger, F; Wurnig, P, 1983)
"In severe appendicitis, the effect of a single intravenous dose of metronidazole (500 mg) was compared with cefoxitin (1 g)."	5.05	Metronidazole v. cefoxitin in severe appendicitis--a trial to compare a single intraoperative dose of two antibiotics given intravenously. ( Bates, T; Corder, AP; Donaldson, PJ; Harrison, M; Prior, JE, 1983)
"One hundred and eight adult patients undergoing appendicectomy (37 advanced appendicitis and 71 early appendicitis or normal appendices) were randomised into a trial comparing the effects of ampicillin (anti-aerobic) and metronidazole (anti-anaerobic) based regimes."	5.05	Metronidazole v ampicillin: differing effects on the postoperative recovery. ( Chant, AD; Machin, D; Turner, DT, 1984)
"A study on 42 surgical patients was carried out to find out whether cefuroxime may be substituted for gentamicin in combination with metronidazole in the treatment of peritonitis secondary to perforation of appendix."	5.05	Comparison of cefuroxime and gentamicin in combination with metronidazole in the treatment of peritonitis due to perforation of the appendix. ( Arvilommi, H; Saario, I; Silvola, H, 1983)
"We identified children who underwent surgery for perforated appendicitis between 2010 and 2018 using the PearlDiver database and compared 45-day disease-specific readmission between children who received shortened (5-8 days) versus prolonged (10-14 day) total antibiotic courses (inpatient intravenous and/or oral) completed with outpatient Amoxicillin/Clavulanate versus Ciprofloxacin/Metronidazole, and compared antibiotic type (5-14 days) to each other."	4.31	A shortened course of Amoxicillin/Clavulanate is the preferred antibiotic treatment after surgery for perforated appendicitis in children. ( Becerra, AZ; Gulack, BC; Madonna, MB; Pillai, S; Shah, AN; Skertich, NJ; Sullivan, GA; Wiegmann, AL, 2023)
"Recent studies are discordant regarding postoperative use of piperacillin/tazobactam (PT) versus ceftriaxone/metronidazole (CM) for pediatric complicated appendicitis."	4.31	Postoperative Antibiotics for Complicated Appendicitis in Children: Piperacillin/Tazobactam Versus Ceftriaxone with Metronidazole. ( Abdullah, F; Alayleh, A; Carter, M; De Boer, C; Goldstein, SD; Hu, A; Linton, S; Pitt, JB; Raval, M; Zeineddin, S, 2023)
"Rates of organ space infection and resource utilization were similar in children with complicated appendicitis treated with ceftriaxone plus metronidazole and piperacillin/tazobactam."	4.12	Ceftriaxone with Metronidazole versus Piperacillin/Tazobactam in the management of complicated appendicitis in children: Results from a multicenter pediatric NSQIP analysis. ( Anandalwar, SP; Graham, DA; Hills-Dunlap, JL; Kashtan, MA; Melvin, P; Rangel, SJ, 2022)
"Ceftriaxone combined with metronidazole is superior to cefoxitin alone in preventing SSIs in children with uncomplicated appendicitis."	4.02	Ceftriaxone Combined With Metronidazole is Superior to Cefoxitin Alone in the Management of Uncomplicated Appendicitis in Children: Results from a Multicenter Collaborative Comparative Effectiveness Study. ( Anandalwar, SP; Cameron, DB; Graham, DA; Hills-Dunlap, JL; Kashtan, MA; Melvin, P; Rangel, SJ, 2021)
"After appendectomy due to complicated acute appendicitis (CAA), there are some alternatives as antibiotic scheme: ciprofloxacin/metronidazole; as well as monoscheme based on carbapenems: ertapenem, meropenem, and imipenem."	3.96	Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population. ( Arevalo-Vidal, E; Baquerizo-Burgos, J; Bunces-Orellana, O; Bustos-Galarza, K; Ferrín-Viteri, M; Oleas, R; Puga-Tejada, M, 2020)
"Metronidazole, 30 mg/kg per dose, once daily achieved AUC target attainment for B fragilis with an MIC of 2 mcg/mL or less in pediatric appendicitis patients."	3.91	Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study. ( Anderson, PL; Chen, X; Child, J; Jones, RN; MacBrayne, C; Mistry, RD; Parker, SK; Somme, S, 2019)
" Historically, a triple-antibiotic therapy consisted of ampicillin, gentamicin, and clindamycin has been used postoperatively for perforated appendicitis."	3.88	Dual versus Triple Antibiotics Regimen in Children with Perforated Acute Appendicitis. ( Baazov, A; Dreznik, Y; Feigin, E; Freud, E; Kravarusic, D; Levy, I; Livni, G; Samuk, I, 2018)
"The aim of this study was to evaluate the efficacy of combined therapy with metronidazole and broad-spectrum antibiotics for patients with perforated appendicitis who underwent surgical intervention."	3.85	The efficacy of combined therapy with metronidazole and broad-spectrum antibiotics on postoperative outcomes for pediatric patients with perforated appendicitis. ( Geng, Q; Guo, C; Shang, Q; Zhang, X, 2017)
"Children undergoing laparoscopic appendectomy for perforated appendicitis were prospectively observed after institution of a new antibiotic regimen consisting of daily intravenous dosing ceftriaxone/metronidazole while an inpatient."	3.81	Safety of a new protocol decreasing antibiotic utilization after laparoscopic appendectomy for perforated appendicitis in children: A prospective observational study. ( Alemayehu, H; Desai, AA; Holcomb, GW; St Peter, SD, 2015)
"All patients with acute appendicitis at Sahlgrenska University Hospital (May 2009 and February 2010) were offered intravenous piperacillin plus tazobactam according to our previous experience, followed by 9 days out-hospital oral ciprofloxacin plus metronidazole."	3.78	Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. ( Hansson, J; Johnsson, E; Jönsson, C; Körner, U; Ludwigs, K; Lundholm, K, 2012)
"In complicated appendicitis, empirical perioperative addition of gentamycin to ceftriaxone and metronidazole did not reduce the risk of developing intra-abdominal abscess, compared to changing antibiotics on clinical grounds."	3.74	Antibiotics and postoperative abscesses in complicated appendicitis: is there any association? ( Chan, TK; Chui, CH; Jacobsen, AS; Ong, CP, 2008)
"Metronidazole was used for treatment of 212 patients with peritonitis of appendicular origin."	3.67	[Metronidazole in the complex treatment of peritonitis of appendicular etiology in children]. ( Astakhov, AA; Kharchenko, DM; Sleptsov, VP; Slezkin, GA, 1987)
"Thirty two consecutive children who underwent surgery for suspected acute appendicitis, were treated with prophylactic metronidazole suppositories."	3.67	[Effectiveness of rectal metromidazole in acute infantile appendicitis]. ( Arcelus, R; Bonal, J; Canals, MP; Cubells, J; Farré, R; Mangues, MA; Puig, I; Torras, A, 1986)
"Prospective investigation of consecutive children suffering from non-perforating appendicitis indicated that metronidazole prophylaxis significantly reduces the risk of postoperative wound sepsis regardless of the method of closure."	3.66	The influence of metronidazole prophylaxis and the method of closure on wound infection in non-perforating appendicitis in childhood. ( Boston, VE; Buick, RG; McLean, MD, 1983)
"A study comparing the effectiveness of metronidazole and ampicillin in preventing wound infection in gangrenous or perforated appendicitis without general peritonitis was performed."	3.66	Effect of metronidazole and ampicillin on patients with gangrenous or perforated appendicitis. A comparative study. ( Bergan, T; Jakobsen, A; Liavåg, I; Roland, M, 1981)
"Fifty-four consecutive children with performed appendicitis were treated with intravenous and rectal metronidazole combined with another antimicrobial agent."	3.66	Perforated appendicitis in children: use of metronidazole for the reduction of septic complications. ( Guiney, EJ; O'Donnell, B; Puri, P; Rangecroft, L; Zervos, G, 1981)
"Sixty-four consecutive patients appendicectomized for perforated appendicitis were studied retrospectively to assess the effect of peroperative metronidazolee on postoperative infections."	3.66	Metronidazole and appendicitis. Can a preoperative prophylaxis be changed to a peroperative treatment in high risk patients? ( Gottrup, F; Saksø, P, 1981)
"Children suspected of having appendicitis were treated with preoperative metronidazole per rectum and then postoperative metronidazole per rectum until the drug could be administered orally."	3.66	Pre- and postoperative rectal metronidazole for the prevention of wound infection in childhood appendicitis. ( Ford, WD; MacKellar, A; Richardson, CJ, 1980)
"To determine the late recurrence rate of appendicitis after antibiotic therapy for the treatment of uncomplicated acute appendicitis."	2.87	Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. ( Aarnio, M; Grönroos, JM; Hurme, S; Jartti, A; Mecklin, JP; Nordström, P; Paajanen, H; Rantanen, T; Rautio, T; Salminen, P; Sand, J; Tuominen, R; Virtanen, J, 2018)
"Intestinal amoebiasis is a parasitic infection caused by Entamoeba histolytica."	2.82	Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review. ( Habiburrahman, M; Handjari, DR; Krisnuhoni, E; Putranto, AS; Rahadiani, N; Stephanie, M, 2022)
"Of these 22, only 1 patient (5%) had recurrence of acute appendicitis during follow-up."	2.80	Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. ( Almström, M; Eaton, S; Hall, NJ; Naji, H; Patkova, B; Pierro, A; Svensson, JF; Wester, T, 2015)
" All patients were treated with once-daily dosing of ceftriaxone and metronidazole throughout their course."	2.80	Saline vs Tissue Plasminogen Activator Irrigations after Drain Placement for Appendicitis-Associated Abscess: A Prospective Randomized Trial. ( Adibe, OO; Cully, B; Holcomb, GW; Reading, B; Rivard, DC; Shah, SR; Sharp, SW; St Peter, SD, 2015)
"None of these patients had a fever or leukocytosis at discharge."	2.70	Oral antibiotics in the management of perforated appendicitis in children. ( Abarbanell, A; Gollin, G; Moores, D, 2002)
"Surgical wound infections were significantly reduced by the collagen-gentamicin implant."	2.69	Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds. ( Delgado, FJ; Guerrero, TS; Guzmán Valdivia Gomez, G; Lluck, MC, 1999)
"Cefepime is a new extended-spectrum cephalosporin with gram-positive and gram-negative coverage including Staphylococcus aureus and Pseudomonas aeruginosa."	2.67	Analysis of cefepime tissue penetration into human appendix. ( Appleman, MD; Berne, TV; Chin, A; Gill, MA; Heseltine, PN; Knupp, CA; Okamoto, MP; Sclar, DA; Yellin, AE, 1991)
"Metronidazole (M) has potent bactericidal activity against anaerobic bacteria."	2.65	Prospective, randomized comparison of metronidazole and clindamycin, each with gentamicin, for the treatment of serious intra-abdominal infection. ( , 1983)
"Acute appendicitis is the most frequent surgical emergency in the paediatric population."	1.72	Evidence-based optimisation of empirical antibiotic regimens in paediatric complicated appendicitis: a retrospective study of 94 patients. ( Andrey, V; Crisinel, PA; Gerber, F; Joseph, JM, 2022)
"Although perforated appendicitis is associated with infectious complications, the choice of antibiotic therapy is controversial."	1.62	Reducing Piperacillin and Tazobactam Use for Pediatric Perforated Appendicitis. ( Anderson, VD; Bassett, HK; Bio, LL; Contopoulos-Ioannidis, D; Mueller, C; Rabsatt, LA; Schwenk, HT; Seddik, TB, 2021)
"Eosinophilic gastroenteritis is a rare inflammatory disorder of the gastrointestinal tract."	1.62	Eosinophilic gastroenteritis in an adolescent male with history of chronic bullous disease. ( Castor, MAR; Murillo, JML; Recto, MST; Tan-Lim, CSC, 2021)
"Cumulative incidence of surgical site infection was 2."	1.51	Adequacy of antibiotic prophylaxis protocol in appendectomies in children. ( Durán-Poveda, M; García-Cruces, J; Gil-Yonte, P; Rodríguez-Caravaca, G; Rodríguez-Villar, D; Román-Montero, JS, 2019)
"Recurrence is rare and it can be addressed efficiently with the administration of a second course of antibiotics."	1.40	Long-term results of nonoperative treatment for uncomplicated acute appendicitis. ( Aygen, E; Kırkıl, C; Yiğit, MV, 2014)
"Abdominal pain is common feature of Henoch-Schonlein purpura, which may mimic appendicitis, leading to unnecessary laparotomy."	1.35	Gangrenous appendicitis in a child with Henoch-Schonlein purpura. ( Amouzeshi, A; Jalali, AN; Jangjoo, A, 2008)
" Although effective and seemingly inexpensive, this regimen produces a cumbersome dosing schedule, which has inspired the search for a simpler regimen that does not compromise efficacy or expense."	1.33	A simple and more cost-effective antibiotic regimen for perforated appendicitis. ( Andrews, WS; Calkins, CM; Holcomb, GW; Little, DC; Murphy, JP; Ostlie, DJ; Sharp, RJ; Snyder, CL; St Peter, SD, 2006)
"Non-pulmonary tuberculosis is found with different frequencies in different countries of the world."	1.33	Acute isolated tuberculous appendicitis. ( Głowacka, M; Kurek, J; Sandelewski, A; Wyrobiec, G, 2006)
" Due to these pharmacokinetic patterns the results of an earlier prospective trial is confirmed that single-shot antibiotics during surgery are useful to reduce postoperative wound sepsis rate after appendectomy."	1.28	[Use of preventive intra-operative antibiotic administration in appendectomy. A pharmacokinetic study]. ( Adamek, L; Mayer, F; Raguse, T; Wolf, R, 1991)

Research

Studies (155)

Authors

Clinical Trials (16)

Trial Overview

Trial Outcomes

The Success of Antibiotic and Surgical Treatment in the Treatment of Acute Uncomplicated Appendicitis

Timeframe	Studies, this research(%)	All Research%
pre-1990	57 (36.77)	18.7374
1990's	20 (12.90)	18.2507
2000's	25 (16.13)	29.6817
2010's	39 (25.16)	24.3611
2020's	14 (9.03)	2.80

Authors	Studies
Kashtan, MA	2
Graham, DA	3
Melvin, P	3
Hills-Dunlap, JL	2
Anandalwar, SP	2
Rangel, SJ	3
Elrod, J	1
Yarmal, F	1
Mohr, C	1
Dennebaum, M	1
Boettcher, M	1
Vincent, D	1
Reinshagen, K	1
Koenigs, I	1
Skertich, NJ	1
Sullivan, GA	1
Wiegmann, AL	1
Becerra, AZ	1
Madonna, MB	1
Pillai, S	1
Shah, AN	1
Gulack, BC	1
Rahadiani, N	1
Habiburrahman, M	1
Putranto, AS	1
Handjari, DR	1
Stephanie, M	1
Krisnuhoni, E	1
Anzinger, FX	1
Rothe, K	1
Reischl, S	1
Stöss, C	1
Novotny, A	1
Wilhelm, D	1
Friess, H	1
Neumann, PA	1
Gerber, F	1
Joseph, JM	1
Crisinel, PA	1
Andrey, V	1
Zeineddin, S	1
Pitt, JB	1
Linton, S	1
De Boer, C	1
Hu, A	1
Carter, M	1
Alayleh, A	1
Abdullah, F	1
Raval, M	1
Goldstein, SD	1
Pérez Costoya, C	1
Gómez Farpón, A	1
Enríquez Zarabozo, EM	1
Granell Suárez, C	1
Vega Mata, N	1
Amat Valero, S	1
Álvarez Muñoz, V	1
Fonnes, S	1
Weisser, JJ	1
Holzknecht, BJ	1
Arpi, M	1
Rosenberg, J	1
Cameron, DB	2
Bunces-Orellana, O	1
Arevalo-Vidal, E	1
Bustos-Galarza, K	1
Ferrín-Viteri, M	1
Oleas, R	1
Baquerizo-Burgos, J	1
Puga-Tejada, M	1
Seddik, TB	1
Rabsatt, LA	1
Mueller, C	1
Bassett, HK	1
Contopoulos-Ioannidis, D	1
Bio, LL	1
Anderson, VD	1
Schwenk, HT	1
Sippola, S	3
Haijanen, J	2
Grönroos, J	3
Rautio, T	5
Nordström, P	5
Rantanen, T	5
Pinta, T	1
Ilves, I	1
Mattila, A	1
Rintala, J	1
Löyttyniemi, E	1
Hurme, S	6
Tammilehto, V	1
Marttila, H	1
Meriläinen, S	1
Laukkarinen, J	1
Sävelä, EL	1
Savolainen, H	1
Sippola, T	1
Aarnio, M	5
Paajanen, H	5
Salminen, P	6
Tan-Lim, CSC	1
Murillo, JML	1
Recto, MST	1
Castor, MAR	1
Glass, CC	1
Serres, SK	1
Kronman, MP	1
Saito, JM	1
Tuominen, R	4
Mueck, KM	1
Putnam, LR	1
Anderson, KT	1
Lally, KP	1
Tsao, K	2
Kao, LS	1
Dreznik, Y	1
Feigin, E	1
Samuk, I	1
Kravarusic, D	1
Baazov, A	1
Levy, I	1
Livni, G	1
Freud, E	1
Shang, Q	1
Geng, Q	1
Zhang, X	1
Guo, C	1
Taleb, M	1
Nardi, N	1
Arnaud, A	1
Costet, N	1
Donnio, PY	1
Engrand, C	1
Habonimana, E	1
Wodey, E	1
Tattevin, P	1
Child, J	2
Chen, X	1
Mistry, RD	1
Somme, S	2
MacBrayne, C	1
Anderson, PL	1
Jones, RN	1
Parker, SK	2
Mecklin, JP	2
Sand, J	2
Virtanen, J	2
Jartti, A	2
Grönroos, JM	3
Rhyne, RR	1
Hale, AL	1
Watson, DS	1
Smith, DE	1
Iio, K	1
Ariyama, Y	1
Tomita, H	1
Sakakibara, H	1
Hataya, H	1
Durán-Poveda, M	1
Gil-Yonte, P	1
Rodríguez-Villar, D	1
García-Cruces, J	1
Rodríguez-Caravaca, G	1
Román-Montero, JS	1
Yefet, E	1
Romano, S	1
Chazan, B	1
Nachum, Z	1
Whelan-Johnson, S	1
Isaacs, J	1
Pullan, RD	1
Knott, EM	1
Thomas, P	1
Sharp, NE	1
Gasior, AC	1
St Peter, SD	6
Obinwa, O	1
Casidy, M	1
Flynn, J	1
Park, HC	2
Kim, MJ	2
Lee, BH	2
Svensson, JF	1
Patkova, B	1
Almström, M	1
Naji, H	1
Hall, NJ	1
Eaton, S	1
Pierro, A	1
Wester, T	1
Kırkıl, C	1
Yiğit, MV	1
Aygen, E	1
Desai, AA	1
Alemayehu, H	1
Holcomb, GW	5
Rinta-Kiikka, I	1
Shah, SR	1
Adibe, OO	1
Sharp, SW	3
Reading, B	1
Cully, B	1
Rivard, DC	1
Rafiq, MS	1
Khan, MM	1
Khan, A	1
Jan, H	1
Minneci, PC	1
Mahida, JB	1
Lodwick, DL	1
Sulkowski, JP	1
Nacion, KM	1
Cooper, JN	1
Ambeba, EJ	1
Moss, RL	1
Deans, KJ	1
Vahdad, MR	1
Nissen, M	1
Semaan, A	1
Klein, T	1
Palade, E	1
Boemers, T	1
Foroutan, HR	1
Troebs, RB	1
Cernaianu, G	1
Hurst, AL	1
Olson, D	1
Pyle, L	1
Ranade, D	1
Stamatoiu, A	1
Crombleholme, T	1
Yousaf, A	1
Ahmed, M	1
Aurangzeb, M	1
van Hulsteijn, LT	1
Mieog, JS	1
Zwartbol, MH	1
Merkus, JW	1
van Nieuwkoop, C	1
Talan, DA	1
Saltzman, DJ	1
Mower, WR	1
Krishnadasan, A	1
Jude, CM	1
Amii, R	1
DeUgarte, DA	1
Wu, JX	1
Pathmarajah, K	1
Morim, A	1
Moran, GJ	1
Spilde, TL	1
Murphy, JP	3
Snyder, CL	3
Sharp, RJ	3
Andrews, WS	3
Ostlie, DJ	3
Paladino, JA	1
Gilliland-Johnson, KK	1
Adelman, MH	1
Cohn, SM	2
Ong, CP	1
Chan, TK	1
Chui, CH	1
Jacobsen, AS	1
Tuduri, I	1
Jangjoo, A	1
Amouzeshi, A	1
Jalali, AN	1
Malik, AA	1
Bari, SU	1
Weiss, G	1
Reimnitz, P	1
Hampel, B	1
Muehlhofer, E	1
Lippert, H	1
Fraser, JD	1
Aguayo, P	1
Leys, CM	1
Keckler, SJ	1
Newland, JG	1
Leeuwenburgh, MM	1
Monpellier, V	1
Vlaminckx, BJ	1
Go, PM	2
Hansson, J	1
Körner, U	1
Ludwigs, K	1
Johnsson, E	1
Jönsson, C	1
Lundholm, K	1
Andersson, RE	1
Schein, M	1
Christodoulidou, M	1
Thomas, M	1
Sharma, SD	1
Coccolini, F	1
Pisano, M	1
Magnone, S	1
Colaianni, N	1
Campanati, L	1
Catena, F	1
Ansaloni, L	1
Garg, PK	1
Mohanty, D	1
Hussain, MI	1
Alam, MK	1
Al-Qahatani, HH	1
Al-Akeely, MH	1
Flint, R	1
Gollin, G	2
Abarbanell, A	1
Moores, D	1
Velez, MC	1
Athale, UH	1
Loe, W	1
Warrier, RP	1
Emil, S	1
Laberge, JM	1
Mikhail, P	1
Baican, L	1
Flageole, H	1
Nguyen, L	1
Shaw, K	1
Lodha, A	1
Wales, PW	1
James, A	1
Smith, CR	1
Langer, JC	1
Mui, LM	1
Ng, CS	1
Wong, SK	1
Lam, YH	1
Fung, TM	1
Fok, KL	1
Chung, SS	1
Ng, EK	1
Kujath, P	1
Rauh, V	1
Weisser, C	1
Hofmann, G	1
Vane, DW	1
Fernandez, N	1
Little, DC	1
Calkins, CM	1
Ferrer, J	1
Fondevila, C	1
Bombuy, E	1
Fuster, J	1
Alvarez, G	1
Charco, R	1
García-Valdecasas, JC	1
Wyrobiec, G	1
Sandelewski, A	1
Głowacka, M	1
Kurek, J	1
Zerem, E	1
Salkic, N	1
Imamovic, G	1
Terzić, I	1
Khan, MN	1
Vidya, R	1
Lee, RE	1
Ishihara, S	1
Kitayama, J	1
Nagawa, H	1
Andrade, JE	1
Mederos, R	1
Rivero, H	1
Sendzischew, MA	1
Soaita, M	1
Robinson, MJ	1
Sendzischew, H	1
Danielpour, P	1
Robinson, AS	1
Levinson, M	1
Smith, JA	2
Forward, AD	2
Skidmore, AG	1
Bell, GA	2
Murphy, JM	1
Sutherland, E	1
Flannigan, GM	1
Clifford, RP	1
Carver, RA	1
Yule, AG	1
Madden, NP	1
Saario, I	1
Arvilommi, H	1
Silvola, H	1
Miholić, J	1
Riezinger, F	1
Wurnig, P	1
Schultz, A	1
Jørgensen, PM	1
Jørgensen, SP	1
Orr, JD	1
Ziman, P	1
Lukes, R	1
Marcisin, J	1
Lipcák, P	1
Benko, A	1
Stramba, S	1
Koren, B	1
Durasko, I	1
Tarshis, VE	2
Bronskaia, LK	1
Bogomolova, NS	1
Khromov, IaA	1
Williams, R	1
Corder, AP	1
Bates, T	1
Prior, JE	1
Harrison, M	1
Donaldson, PJ	1
McLean, MD	1
Buick, RG	1
Boston, VE	1
Chant, AD	1
Turner, DT	1
Machin, D	1
Roland, M	1
Bergan, T	1
Jakobsen, A	1
Liavåg, I	1
Gottrup, F	3
Brennan, SS	1
Smith, GM	1
Evans, M	1
Pollock, AV	1
Saksø, P	2
Puri, P	1
Rangecroft, L	1
Zervos, G	1
Guiney, EJ	1
O'Donnell, B	1
Pinto, DJ	1
Sanderson, PJ	1
Stewart, D	1
Kingsnorth, A	1
Ford, WD	1
MacKellar, A	1
Richardson, CJ	1
Gahukamble, DB	1
Khamage, AS	1
Gahukamble, LD	1
Badía, JM	1
Martínez-Ródenas, F	1
Oms, LM	1
Valverde, J	1
Franch, G	1
Rosales, A	1
Serrano, R	1
Sitges-Serra, A	1
Schmitt, M	2
Bondonny, JM	2
Delmas, P	2
Galifer, RB	2
Revillon, Y	2
Robert, M	2
Berne, TV	2
Yellin, AE	3
Appleman, MD	2
Heseltine, PN	2
Gill, MA	2
Suata, K	1
Watanabe, K	1
Ueno, K	1
Homma, M	1
Söderquist-Elinder, C	1
Hirsch, K	1
Bergdahl, S	1
Rutqvist, J	1
Frenckner, B	1
Miasnikova, NA	1
Levy, Y	1
Berger, SA	1
Gorea, A	1
Shnaker, A	1
Orda, R	1
Shubing, W	1
Litian, Z	1
Barie, PS	1
Vogel, SB	1
Dellinger, EP	1
Rotstein, OD	1
Solomkin, JS	1
Yang, JY	1
Baumgartner, TF	1
Guzmán Valdivia Gomez, G	1
Guerrero, TS	1
Lluck, MC	1
Delgado, FJ	1
Banani, SA	1
Talei, A	1
Ohlin, B	1
Cederberg, A	1
Forssell, H	1
Solhaug, JH	1
Tveit, E	1
Lipsett, PA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Assessing the Longitudinal Outcomes of Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA): a Randomized Controlled Trial[NCT05943223]	Phase 2	16 participants (Anticipated)	Interventional	2024-01-31	Not yet recruiting
Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis: a Prospective Randomised Multicenter Study (The APPAC II Study)[NCT03236961]		552 participants (Anticipated)	Interventional	2017-04-03	Active, not recruiting
Study of Surgical Treatment (Open Appendicectomy) Versus Antibiotic Treatment (Ertapenem) in the Treatment of Acute Uncomplicated Appendicitis[NCT01022567]		530 participants (Actual)	Interventional	2009-11-30	Active, not recruiting
Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases[NCT04462588]		64 participants (Actual)	Observational [Patient Registry]	2019-06-01	Completed
Conservative Treatment of Acute Appendicitis in Children Pilot Trial[NCT01572558]		51 participants (Actual)	Interventional	2012-02-29	Completed
Preoperative Immature Granulocyte Count and Percentage for Complicated and Uncomplicated Appendisitis[NCT04440150]		70 participants (Actual)	Interventional	2018-06-01	Completed
Multicenter Prospective Randomized Clinical Trial Comparing Endoscopic Retrograde Appendicitis Therapy (ERAT) vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis[NCT02789865]	Phase 2	240 participants (Anticipated)	Interventional	2016-05-31	Not yet recruiting
Mutil-institutions Comparing Antibiotic Therapy With Laparscopic Appendectomy in Pediatric Chronic Appendicitis[NCT03754387]		200 participants (Anticipated)	Interventional	2019-01-01	Enrolling by invitation
A Prospective Non-randomized Controlled, Multicenter, Multidisciplinary Trial Comparing Appendectomy and Conservative Treatment for Patients With Uncomplicated Acute Appendicitis (the ACTUAA STUDY).[NCT03080103]		300 participants (Actual)	Observational	2017-06-01	Completed
Single Incision Versus Standard Laparoscopic Appendectomy for Non-Perforated Appendicitis[NCT00981136]		360 participants (Actual)	Interventional	2009-08-31	Completed
Non-operative Management of Early Appendicitis in Children[NCT01718275]		102 participants (Actual)	Observational	2012-10-31	Active, not recruiting
Multi-institutional Trial of Non-operative Management of Uncomplicated Pediatric Appendicitis[NCT02271932]		1,076 participants (Actual)	Observational	2014-10-01	Active, not recruiting
Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain[NCT01096927]	Phase 4	160 participants (Actual)	Interventional	2010-01-31	Completed
Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis (Randomized, Controlled Clinical Trial)[NCT01115153]		150 participants (Actual)	Interventional	2007-12-31	Completed
PROTOP: Study of the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Localization Infection in Colorectal Surgery[NCT03574090]	Phase 4	268 participants (Actual)	Interventional	2020-10-20	Completed
Collagen-Gentamicin Implant in the Treatment of Contaminated Surgical Abdominal Wounds - A Randomized Controlled Trial[NCT00977405]	Phase 2	70 participants (Anticipated)	Interventional	2009-09-30	Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

A successful treatment is determined by resolution of the appendicitis by means of the assigned treatment. (NCT01022567)
Timeframe: Up to 10 years

Article	Year
Fulminant necrotizing amoebic colitis presenting as acute appendicitis: a case report and comprehensive literature review. Journal of infection in developing countries, 2022, 04-30, Volume: 16, Issue:4 Topics: Acute Disease; Appendicitis; Dysentery, Amebic; Entamoeba histolytica; Humans; Intestines; Male; Met	2022
Antibiotic prophylaxis in acute non-perforated appendicitis in children: single dose of metronidazole and gentamicin. Journal of the Royal College of Surgeons of Edinburgh, 1992, Volume: 37, Issue:2 Topics: Acute Disease; Adolescent; Appendicitis; Child; Child, Preschool; Female; Gentamicins; Humans; Male;	1992
Surgical problems in amoebiasis. Annals of the Royal College of Surgeons of England, 1973, Volume: 52, Issue:1 Topics: Abscess; Amebiasis; Amebicides; Anti-Bacterial Agents; Appendicitis; Colonic Diseases; Dysentery, Am	1973

Article	Year
The plasma pharmacokinetics of fosfomycin and metronidazole after intraperitoneal administration in patients undergoing appendectomy for uncomplicated appendicitis. Fundamental & clinical pharmacology, 2020, Volume: 34, Issue:4 Topics: Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; Denmark; Drug Combinations; Dr	2020
Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis: The APPAC II Randomized Clinical Trial. JAMA, 2021, 01-26, Volume: 325, Issue:4 Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Anti-Bacterial Agents; Appe	2021
Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial. The British journal of surgery, 2017, Volume: 104, Issue:10 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; C	2017
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 2018, 09-25, Volume: 320, Issue:12 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D	2018
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 2018, 09-25, Volume: 320, Issue:12 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D	2018
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 2018, 09-25, Volume: 320, Issue:12 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D	2018
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial. JAMA, 2018, 09-25, Volume: 320, Issue:12 Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; beta-Lactams; D	2018
Cost analysis of antibiotic therapy versus appendectomy for treatment of uncomplicated acute appendicitis: 5-year results of the APPAC randomized clinical trial. PloS one, 2019, Volume: 14, Issue:7 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2019
Reduced use of computed tomography in patients treated with interval appendectomy after implementing a protocol from a prospective, randomized trial. Pediatric surgery international, 2013, Volume: 29, Issue:12 Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; Child; Drainage; Female; Follow-Up S	2013
The outcome of antibiotic therapy for uncomplicated appendicitis with diameters ≤ 10 mm. International journal of surgery (London, England), 2014, Volume: 12, Issue:9 Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cephalosp	2014
Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. Annals of surgery, 2015, Volume: 261, Issue:1 Topics: Abdominal Pain; Acute Disease; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Child;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial. JAMA, 2015, Jun-16, Volume: 313, Issue:23 Topics: Acute Disease; Administration, Intravenous; Adolescent; Adult; Anti-Bacterial Agents; Appendectomy;	2015
Saline vs Tissue Plasminogen Activator Irrigations after Drain Placement for Appendicitis-Associated Abscess: A Prospective Randomized Trial. Journal of the American College of Surgeons, 2015, Volume: 221, Issue:2 Topics: Abdominal Abscess; Adolescent; Anti-Infective Agents; Appendicitis; Ceftriaxone; Child; Child, Presc	2015
Evaluation of postoperative antibiotics after non-perforated appendectomy. JPMA. The Journal of the Pakistan Medical Association, 2015, Volume: 65, Issue:8 Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Cefuro	2015
Antibiotics-First Versus Surgery for Appendicitis: A US Pilot Randomized Controlled Trial Allowing Outpatient Antibiotic Management. Annals of emergency medicine, 2017, Volume: 70, Issue:1 Topics: Administration, Intravenous; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendectomy; Appendici	2017
Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial. Journal of pediatric surgery, 2008, Volume: 43, Issue:6 Topics: Abscess; Administration, Oral; Adolescent; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Ceftr	2008
Pharmacoeconomics of ciprofloxacin plus metronidazole vs. piperacillin-tazobactam for complicated intra-abdominal infections. Surgical infections, 2008, Volume: 9, Issue:3 Topics: Abdominal Abscess; Adult; Aged; Anti-Bacterial Agents; Appendicitis; Ciprofloxacin; Cost-Benefit Ana	2008
Conservative management of acute appendicitis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009, Volume: 13, Issue:5 Topics: Adolescent; Adult; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ciprofloxacin; Female; Follow-	2009
Moxifloxacin for the treatment of patients with complicated intra-abdominal infections (the AIDA Study). Journal of chemotherapy (Florence, Italy), 2009, Volume: 21, Issue:2 Topics: Abdominal Abscess; Administration, Oral; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination;	2009
A complete course of intravenous antibiotics vs a combination of intravenous and oral antibiotics for perforated appendicitis in children: a prospective, randomized trial. Journal of pediatric surgery, 2010, Volume: 45, Issue:6 Topics: Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; C	2010
Role of postoperative antibiotics after appendectomy in non-perforated appendicitis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2012, Volume: 22, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendectomy; Appendi	2012
Oral antibiotics in the management of perforated appendicitis in children. The American surgeon, 2002, Volume: 68, Issue:12 Topics: Administration, Oral; Adolescent; Anti-Bacterial Agents; Anti-Infective Agents; Appendectomy; Append	2002
Optimum duration of prophylactic antibiotics in acute non-perforated appendicitis. ANZ journal of surgery, 2005, Volume: 75, Issue:6 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Appen	2005
[Controlled, open, parallel-group study of the clinical and microbiological efficacy of piperacillin-tazobactam versus metronidazole + gentamicin in urgent colorectal surgery]. Cirugia espanola, 2006, Volume: 79, Issue:6 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Appendicitis; Drug Administratio	2006
Comparison of therapeutic effectiveness of percutaneous drainage with antibiotics versus antibiotics alone in the treatment of periappendiceal abscess: is appendectomy always necessary after perforation of appendix? Surgical endoscopy, 2007, Volume: 21, Issue:3 Topics: Abscess; Adult; Ampicillin; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cefuroxime; Combined	2007
Metronidazole in the treatment of intra-abdominal sepsis. Surgery, 1983, Volume: 93, Issue:1 Pt 2 Topics: Abdomen; Abscess; Adult; Aged; Appendicitis; Bacterial Infections; Clindamycin; Clinical Trials as T	1983
Antibiotic prophylaxis in acute appendicitis. Surgery, gynecology & obstetrics, 1983, Volume: 156, Issue:2 Topics: Acute Disease; Administration, Oral; Adolescent; Appendectomy; Appendicitis; Clinical Trials as Topi	1983
Comparison of cefuroxime and gentamicin in combination with metronidazole in the treatment of peritonitis due to perforation of the appendix. Acta chirurgica Scandinavica, 1983, Volume: 149, Issue:4 Topics: Adult; Appendicitis; Bacteria; Cefuroxime; Cephalosporins; Clinical Trials as Topic; Drug Therapy, C	1983
Metronidazole plus cefazolin versus cefazolin in gangrenous and perforated appendicitis in childhood--a prospective randomised trial. Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1983, Volume: 38, Issue:3 Topics: Appendicitis; Appendix; Cefazolin; Child; Clinical Trials as Topic; Drug Therapy, Combination; Gangr	1983
Septic complications after appendicectomy for perforated appendicitis. A controlled clinical trial metronidazole and topical ampicillin. Acta chirurgica Scandinavica, 1983, Volume: 149, Issue:5 Topics: Adolescent; Adult; Aged; Ampicillin; Appendectomy; Appendicitis; Child; Child, Preschool; Clinical T	1983
Metronidazole v. cefoxitin in severe appendicitis--a trial to compare a single intraoperative dose of two antibiotics given intravenously. Postgraduate medical journal, 1983, Volume: 59, Issue:697 Topics: Adult; Appendicitis; Cefoxitin; Child; Child, Preschool; Female; Humans; Intraoperative Period; Leng	1983
A Danish multicenter study: cefoxitin versus ampicillin + metronidazole in perforated appendicitis. The British journal of surgery, 1984, Volume: 71, Issue:2 Topics: Abdomen; Abscess; Adolescent; Adult; Aged; Ampicillin; Appendectomy; Appendicitis; Cefoxitin; Child;	1984
Metronidazole v ampicillin: differing effects on the postoperative recovery. Annals of the Royal College of Surgeons of England, 1984, Volume: 66, Issue:2 Topics: Adolescent; Ampicillin; Appendectomy; Appendicitis; Female; Fever; Humans; Male; Metronidazole; Post	1984
Prospective, randomized comparison of metronidazole and clindamycin, each with gentamicin, for the treatment of serious intra-abdominal infection. Surgery, 1983, Volume: 93, Issue:1 Pt 2 Topics: Abdomen; Abscess; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendicitis; Bacterial Infections	1983
Prophylactic metronidazole in prevention of infection after appendicectomy: report of a double-blind trial. Acta chirurgica Scandinavica, 1980, Volume: 146, Issue:2 Topics: Adolescent; Adult; Appendectomy; Appendicitis; Bacterial Infections; Bacteroides fragilis; Child; Cl	1980
The management of the perforated appendix: a controlled clinical trial. The British journal of surgery, 1982, Volume: 69, Issue:9 Topics: Adult; Aged; Appendectomy; Appendicitis; Clinical Trials as Topic; Drug Administration Schedule; Hum	1982
Rational use of antibiotic therapy after appendicectomy. British medical journal, 1980, Feb-02, Volume: 280, Issue:6210 Topics: Adolescent; Adult; Aged; Ampicillin; Appendectomy; Appendicitis; Child; Child, Preschool; Female; Ga	1980
[A randomized prospective study of antibiotic prophylaxis compared to lavage of the surgical wound in nonperforating appendicitis]. Medicina clinica, 1994, Jul-09, Volume: 103, Issue:6 Topics: Acute Disease; Adolescent; Adult; Appendectomy; Appendicitis; Chi-Square Distribution; Child; Female	1994
[Antibiotic therapy of perforated appendicitis in children: comparison between the amoxicillin-clavulanic acid and the benzylpenicillin-netilmicin-metronidazole combinations]. Pediatrie, 1993, Volume: 48, Issue:9 Topics: Adolescent; Amoxicillin; Appendicitis; Child; Child, Preschool; Clavulanic Acids; Drug Therapy, Comb	1993
A clinical comparison of cefepime and metronidazole versus gentamicin and clindamycin in the antibiotic management of surgically treated advanced appendicitis. Surgery, gynecology & obstetrics, 1993, Volume: 177 Suppl Topics: Adolescent; Adult; Appendicitis; Cefepime; Cephalosporins; Clindamycin; Double-Blind Method; Drug Ad	1993
Prophylactic antibiotics in uncomplicated appendicitis during childhood--a prospective randomised study. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 1995, Volume: 5, Issue:5 Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendicitis; Appendix; Bacterial Infecti	1995
Penetration of clindamycin and metronidazole into inflamed appendiceal tissue. The European journal of surgery = Acta chirurgica, 1996, Volume: 162, Issue:8 Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendicitis; Appendix; Clindamycin; Drug Ther	1996
Preventing infection of the incision after appendectomy by using metronidazole preoperatively to infiltrate tissues at the incision. American journal of surgery, 1997, Volume: 174, Issue:4 Topics: Acute Disease; Adult; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Cefazolin; Cephalosporins;	1997
A randomized, double-blind clinical trial comparing cefepime plus metronidazole with imipenem-cilastatin in the treatment of complicated intra-abdominal infections. Cefepime Intra-abdominal Infection Study Group. Archives of surgery (Chicago, Ill. : 1960), 1997, Volume: 132, Issue:12 Topics: Abdomen; Abdominal Abscess; Adult; Aged; Antitrichomonal Agents; Appendicitis; Cefepime; Cephalospor	1997
Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds. World journal of surgery, 1999, Volume: 23, Issue:2 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local;	1999
Can oral metronidazole substitute parenteral drug therapy in acute appendicitis? A new policy in the management of simple or complicated appendicitis with localized peritonitis: a randomized controlled clinical trial. The American surgeon, 1999, Volume: 65, Issue:5 Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Appendicitis; Ceftizo	1999
Piperacillin/tazobactam compared with cefuroxime/ metronidazole in the treatment of intra-abdominal infections. The European journal of surgery = Acta chirurgica, 1999, Volume: 165, Issue:9 Topics: Abdominal Abscess; Appendicitis; Bacterial Infections; beta-Lactamase Inhibitors; Cefuroxime; Drug T	1999
Comparison of intravenous/oral ciprofloxacin plus metronidazole versus piperacillin/tazobactam in the treatment of complicated intraabdominal infections. Annals of surgery, 2000, Volume: 232, Issue:2 Topics: Abdomen; Abdominal Abscess; Administration, Oral; Anti-Infective Agents; Appendicitis; Bacterial Inf	2000
Piperacillin/Tazobactam versus cefotaxime plus metronidazole for treatment of children with intra-abdominal infections requiring surgery. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2001, Volume: 20, Issue:9 Topics: Abdominal Abscess; Adolescent; Appendicitis; Bacterial Infections; Cefotaxime; Child; Child, Prescho	2001
Results of a pilot trial comparing prolonged intravenous antibiotics with sequential intravenous/oral antibiotics for children with perforated appendicitis. Archives of surgery (Chicago, Ill. : 1960), 2001, Volume: 136, Issue:12 Topics: Administration, Oral; Adolescent; Ampicillin; Appendicitis; Child; Child, Preschool; Clavulanic Acid	2001
Antibiotic prophylaxis in acute non-perforated appendicitis in children: single dose of metronidazole and gentamicin. Journal of the Royal College of Surgeons of Edinburgh, 1992, Volume: 37, Issue:2 Topics: Acute Disease; Adolescent; Appendicitis; Child; Child, Preschool; Female; Gentamicins; Humans; Male;	1992
Imipenem-cilastatin vs. tobramycin and metronidazole for appendicitis-related infections. The Pediatric infectious disease journal, 1992, Volume: 11, Issue:6 Topics: Adolescent; Anti-Bacterial Agents; Appendicitis; Bacterial Infections; Child; Child, Preschool; Cila	1992
Analysis of cefepime tissue penetration into human appendix. Pharmacotherapy, 1991, Volume: 11, Issue:5 Topics: Adolescent; Adult; Appendectomy; Appendicitis; Appendix; Ascitic Fluid; Cefepime; Cephalosporins; Cl	1991
[General or individually calculated preventive antibiotic administration. Summary of the Magdeburg appendicitis study]. Zentralblatt fur Chirurgie, 1991, Volume: 116, Issue:13 Topics: Acute Disease; Adult; Ampicillin; Appendectomy; Appendicitis; Female; Humans; Infusions, Intravenous	1991
Systemic plus local metronidazole and cephazolin in complicated appendicitis: a prospective controlled trial. Journal of the Royal College of Surgeons of Edinburgh, 1989, Volume: 34, Issue:1 Topics: Adolescent; Adult; Appendectomy; Appendicitis; Cefazolin; Child; Clinical Trials as Topic; Drug Ther	1989
[Preventive use of single dose antibiotics in acute appendicitis. Results of a prospective randomized clinical study]. Zentralblatt fur Chirurgie, 1989, Volume: 114, Issue:20 Topics: Adolescent; Adult; Aged; Ampicillin; Appendectomy; Appendicitis; Drug Therapy, Combination; Female;	1989
Antibiotic therapy of perforated appendicitis in children: a comparison of amoxycillin/clavulanate with a combination of benzylpenicillin, netilmicin and metronidazole. The Journal of antimicrobial chemotherapy, 1989, Volume: 24 Suppl B Topics: Amoxicillin; Appendicitis; Child; Child, Preschool; Clavulanic Acids; Drug Therapy, Combination; Fem	1989
Antibiotic prophylaxis in non-perforated appendicitis of childhood: tetracycline lavage compared with peroperative intravenous cefuroxime and metronidazole. The Journal of hospital infection, 1987, Volume: 9, Issue:2 Topics: Adolescent; Anti-Bacterial Agents; Appendicitis; Cefuroxime; Child; Child, Preschool; Female; Humans	1987
Once daily administration of netilmicin compared with thrice daily, both in combination with metronidazole, in gangrenous and perforated appendicitis. The Journal of antimicrobial chemotherapy, 1988, Volume: 22, Issue:1 Topics: Adolescent; Adult; Aged; Appendicitis; Drug Administration Schedule; Drug Therapy, Combination; Fema	1988
[Wound infection following appendectomy. Metronidazole vs ornidazole as single-dose prophylaxis in non-perforated appendix]. Schweizerische medizinische Wochenschrift, 1988, Oct-01, Volume: 118, Issue:39 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Appendicitis; Child; Female; Humans; Intestinal Perforat	1988
Stratified duration of prophylactic antimicrobial treatment in emergency abdominal surgery. Metronidazole-fosfomycin vs. metronidazole-gentamicin in 381 patients. Acta chirurgica Scandinavica, 1987, Volume: 153, Issue:3 Topics: Abdomen, Acute; Adolescent; Adult; Aged; Appendicitis; Cholecystitis; Clinical Trials as Topic; Drug	1987
[Gangrenous appendicitis. Local application of ampicillin in the incision versus intravenous administration of metronidazole used peroperatively]. Ugeskrift for laeger, 1987, Oct-26, Volume: 149, Issue:44 Topics: Administration, Topical; Adolescent; Adult; Aged; Ampicillin; Appendicitis; Appendix; Child; Child,	1987
[Antibiotic treatment of perforated appendicitis in childhood--a prospective study]. Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1986, Volume: 41, Issue:1 Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Child; Clinical Trials as Topic; Drug Combination	1986
A prospective randomized study of continuous peritoneal lavage postoperatively in the treatment of purulent peritonitis. Surgery, gynecology & obstetrics, 1986, Volume: 163, Issue:5 Topics: Adult; Aged; Appendicitis; Bacterial Infections; Cefuroxime; Child; Clinical Trials as Topic; Coloni	1986
[Metronidazole prophylaxis in appendectomy]. Nederlands tijdschrift voor geneeskunde, 1986, Apr-26, Volume: 130, Issue:17 Topics: Adolescent; Adult; Aged; Appendectomy; Appendicitis; Child; Double-Blind Method; Female; Humans; Int	1986
The infective dose of aerobic and anaerobic bacteria in postoperative wound sepsis. Archives of surgery (Chicago, Ill. : 1960), 1986, Volume: 121, Issue:8 Topics: Adolescent; Adult; Aged; Ampicillin; Appendicitis; Appendix; Ascitic Fluid; Bacteria, Aerobic; Bacte	1986
Cefoxitin versus gentamicin and metronidazole in prevention of post-appendicectomy sepsis: a randomized, prospective trial. The Journal of antimicrobial chemotherapy, 1986, Volume: 18, Issue:5 Topics: Adolescent; Adult; Appendectomy; Appendicitis; Bacterial Infections; Cefoxitin; Drug Therapy, Combin	1986
Prevention of post-operative infection in appendicectomy by single dose intravenous metronidazole. An open prospective randomised study. Acta chirurgica Scandinavica, 1985, Volume: 151, Issue:1 Topics: Adolescent; Adult; Aged; Appendectomy; Appendicitis; Child; Doxycycline; Escherichia coli Infections	1985
Metronidazole and Augmentin in the prevention of sepsis after appendicectomy. The British journal of surgery, 1985, Volume: 72, Issue:7 Topics: Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendecto	1985
[Rectal versus intravenous metronidazole treatment following perforated appendicitis. A randomized study]. Ugeskrift for laeger, 1985, Dec-02, Volume: 147, Issue:49 Topics: Adolescent; Aged; Appendectomy; Appendicitis; Child; Child, Preschool; Humans; Injections, Intraveno	1985

Article	Year
Ceftriaxone with Metronidazole versus Piperacillin/Tazobactam in the management of complicated appendicitis in children: Results from a multicenter pediatric NSQIP analysis. Journal of pediatric surgery, 2022, Volume: 57, Issue:10 Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; Child; Humans; Metronidazole; Pipera	2022
Are We Hitting the Target?: The Effectiveness of Distinct Antibiotic Regimens in Pediatric Appendectomies. The Pediatric infectious disease journal, 2022, 06-01, Volume: 41, Issue:6 Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Child; Humans; Metronidazole; Retrospective Studi	2022
A shortened course of Amoxicillin/Clavulanate is the preferred antibiotic treatment after surgery for perforated appendicitis in children. Journal of pediatric surgery, 2023, Volume: 58, Issue:3 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ch	2023
[The importance of microbiological results for the treatment of complicated appendicitis-a monocentric case-control study]. Chirurgie (Heidelberg, Germany), 2022, Volume: 93, Issue:10 Topics: Ampicillin; Anti-Bacterial Agents; Appendicitis; Case-Control Studies; Cephalosporins; Escherichia c	2022
Evidence-based optimisation of empirical antibiotic regimens in paediatric complicated appendicitis: a retrospective study of 94 patients. Swiss medical weekly, 2022, 08-29, Volume: 152 Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; A	2022
Postoperative Antibiotics for Complicated Appendicitis in Children: Piperacillin/Tazobactam Versus Ceftriaxone with Metronidazole. Journal of pediatric surgery, 2023, Volume: 58, Issue:6 Topics: Abdominal Abscess; Abscess; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxo	2023
Analysis of a clinical guideline for treatment and early discharge in complicated acute appendicitis. Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica, 2023, Jul-01, Volume: 36, Issue:3 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ce	2023
Ceftriaxone Combined With Metronidazole is Superior to Cefoxitin Alone in the Management of Uncomplicated Appendicitis in Children: Results from a Multicenter Collaborative Comparative Effectiveness Study. Annals of surgery, 2021, 12-01, Volume: 274, Issue:6 Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Cefoxitin; Ceftriaxone; Child; Drug Therapy, Comb	2021
Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population. Cirugia y cirujanos, 2020, Volume: 88, Issue:3 Topics: Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Carbapenems;	2020
Reducing Piperacillin and Tazobactam Use for Pediatric Perforated Appendicitis. The Journal of surgical research, 2021, Volume: 260 Topics: Adolescent; Anti-Bacterial Agents; Antimicrobial Stewardship; Appendectomy; Appendicitis; Ceftriaxon	2021
Eosinophilic gastroenteritis in an adolescent male with history of chronic bullous disease. BMJ case reports, 2021, Feb-04, Volume: 14, Issue:2 Topics: Abdominal Pain; Adolescent; Anti-Infective Agents; Appendicitis; Diarrhea; Enteritis; Eosinophilia;	2021
Extended Versus Narrow-spectrum Antibiotics in the Management of Uncomplicated Appendicitis in Children: A Propensity-matched Comparative Effectiveness Study. Annals of surgery, 2018, Volume: 268, Issue:1 Topics: Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cefoxitin; Ceftriaxone; Child; Child,	2018
Does compliance with antibiotic prophylaxis in pediatric simple appendicitis matter? The Journal of surgical research, 2017, Volume: 216 Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendectomy; Appendicitis; Cefepime; Cep	2017
Dual versus Triple Antibiotics Regimen in Children with Perforated Acute Appendicitis. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2018, Volume: 28, Issue:6 Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; Chemother	2018
The efficacy of combined therapy with metronidazole and broad-spectrum antibiotics on postoperative outcomes for pediatric patients with perforated appendicitis. Medicine, 2017, Volume: 96, Issue:47 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Appendectomy; Appendicitis; Child, Preschool; Combined	2017
Simplification of first-line antibacterial regimen for complicated appendicitis in children is associated with better adherence to guidelines and reduced use of antibiotics. International journal of antimicrobial agents, 2018, Volume: 52, Issue:2 Topics: Adolescent; Anti-Bacterial Agents; Appendicitis; Cefotaxime; Child; Drug Therapy, Combination; Femal	2018
Pharmacokinetic and Pharmacodynamic Properties of Metronidazole in Pediatric Patients With Acute Appendicitis: A Prospective Study. Journal of the Pediatric Infectious Diseases Society, 2019, Sep-25, Volume: 8, Issue:4 Topics: Acute Disease; Adolescent; Appendicitis; Area Under Curve; Bacteroides fragilis; Child; Child, Presc	2019
Stump Appendicitis Management. The American surgeon, 2018, Dec-01, Volume: 84, Issue:12 Topics: Administration, Oral; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ciprofloxacin; Female; Huma	2018
Long-term Follow-up of Antibiotics vs Surgery for Appendicitis-Reply. JAMA, 2019, 02-19, Volume: 321, Issue:7 Topics: Anti-Bacterial Agents; Appendectomy; Appendicitis; Follow-Up Studies; Humans; Metronidazole	2019
Secondary haemophagocytic lymphohistiocytosis associated with metronidazole. Postgraduate medical journal, 2019, Volume: 95, Issue:1125 Topics: Abdominal Abscess; Appendectomy; Appendicitis; Child; Dexamethasone; Female; Follow-Up Studies; Huma	2019
Adequacy of antibiotic prophylaxis protocol in appendectomies in children. Cirugia y cirujanos, 2019, Volume: 87, Issue:4 Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Antibiotic Prophylaxis; Ap	2019
Successful treatment of acute uncomplicated appendicitis in pregnancy with intravenous antibiotics. European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 169, Issue:1 Topics: Administration, Oral; Adult; Amoxicillin-Potassium Clavulanate Combination; Appendicitis; Female; Ge	2013
Sacro-iliac osteomyelitis in a 13 year old boy following perforated appendicitis. Journal of pediatric surgery, 2013, Volume: 48, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2013
The microbiology of bacterial peritonitis due to appendicitis in children. Irish journal of medical science, 2014, Volume: 183, Issue:4 Topics: Adolescent; Aminoglycosides; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; A	2014
Antibiotic therapy for appendicitis in patients aged ≥80 years. The American journal of medicine, 2014, Volume: 127, Issue:6 Topics: Acute Disease; Aged, 80 and over; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cephalosporins;	2014
Long-term results of nonoperative treatment for uncomplicated acute appendicitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append	2014
Long-term results of nonoperative treatment for uncomplicated acute appendicitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append	2014
Long-term results of nonoperative treatment for uncomplicated acute appendicitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append	2014
Long-term results of nonoperative treatment for uncomplicated acute appendicitis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append	2014
Safety of a new protocol decreasing antibiotic utilization after laparoscopic appendectomy for perforated appendicitis in children: A prospective observational study. Journal of pediatric surgery, 2015, Volume: 50, Issue:6 Topics: Administration, Oral; Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agen	2015
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Effectiveness of Patient Choice in Nonoperative vs Surgical Management of Pediatric Uncomplicated Acute Appendicitis. JAMA surgery, 2016, 05-01, Volume: 151, Issue:5 Topics: Adolescent; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Appendectomy; Appe	2016
Experiences with LESS-appendectomy in Children. Archives of Iranian medicine, 2016, Volume: 19, Issue:1 Topics: Abdominal Abscess; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cefuroxime; Child;	2016
Once-Daily Ceftriaxone Plus Metronidazole Versus Ertapenem and/or Cefoxitin for Pediatric Appendicitis. Journal of the Pediatric Infectious Diseases Society, 2017, Mar-01, Volume: 6, Issue:1 Topics: Abdominal Abscess; Adolescent; Appendectomy; Appendicitis; beta-Lactams; Cefoxitin; Ceftriaxone; Chi	2017
Acute Appendicitis Complicating into Portal and Superior Mesenteric Vein Thrombosis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016, Volume: 26, Issue:6 Suppl Topics: Acute Disease; Adult; Anti-Infective Agents; Anticoagulants; Appendicitis; Humans; Male; Mesenteric	2016
Appendicitis Presenting As Cellulitis of the Right Leg. The Journal of emergency medicine, 2017, Volume: 52, Issue:1 Topics: Aged; Anti-Bacterial Agents; Appendicitis; Cefuroxime; Cellulitis; Emergency Service, Hospital; Esch	2017
Antibiotics and postoperative abscesses in complicated appendicitis: is there any association? Singapore medical journal, 2008, Volume: 49, Issue:8 Topics: Abdominal Abscess; Anti-Bacterial Agents; Appendectomy; Appendicitis; Ceftriaxone; Child; Female; Hu	2008
Considerations about the article by St. Peter "Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomised trial". J Pediatr Surg 2008;43:981-985. Journal of pediatric surgery, 2008, Volume: 43, Issue:10 Topics: Abdominal Abscess; Appendicitis; Cefoxitin; Ceftriaxone; Cefuroxime; Child; Community-Acquired Infec	2008
Gangrenous appendicitis in a child with Henoch-Schonlein purpura. Journal of pediatric surgery, 2008, Volume: 43, Issue:11 Topics: Abdominal Pain; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Arthralgia; Ceftriaxo	2008
Streptococcus milleri in intraabdominal abscesses in children after appendectomy: incidence and course. Journal of pediatric surgery, 2012, Volume: 47, Issue:3 Topics: Abdominal Abscess; Adolescent; Anti-Bacterial Agents; Appendectomy; Appendicitis; Cefuroxime; Child;	2012
Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. World journal of surgery, 2012, Volume: 36, Issue:9 Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Anti-Bacterial Agents; Appe	2012
Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. World journal of surgery, 2012, Volume: 36, Issue:9 Topics: Anti-Bacterial Agents; Appendicitis; Ciprofloxacin; Female; Humans; Male; Metronidazole; Penicillani	2012
Hydronephrosis and loin pain as a presentation of tubo-ovarian abscess developing after Mirena coil removal. BMJ case reports, 2012, Aug-02, Volume: 2012 Topics: Abdominal Pain; Abscess; Adult; Anti-Infective Agents; Appendicitis; Device Removal; Diagnosis, Diff	2012
Antibiotics as first-line therapy for acute appendicitis: evidence for a change in clinical practice. World journal of surgery, 2012, Volume: 36, Issue:12 Topics: Anti-Bacterial Agents; Appendicitis; Ciprofloxacin; Female; Humans; Male; Metronidazole; Penicillani	2012
Mean (standard deviation) or mean (standard error of mean): time to ponder. World journal of surgery, 2013, Volume: 37, Issue:4 Topics: Anti-Bacterial Agents; Appendicitis; Ciprofloxacin; Female; Humans; Male; Metronidazole; Penicillani	2013
Appendiceal diverticulitis and actinomycosis. The New Zealand medical journal, 2002, Jun-07, Volume: 115, Issue:1155 Topics: Actinomycosis; Adult; Anti-Infective Agents; Appendicitis; Cefuroxime; Diagnosis, Differential; Dive	2002
Acute perforative appendicitis during preoperative chemotherapy for Wilms tumor. Pediatric hematology and oncology, 2003, Volume: 20, Issue:2 Topics: Abdominal Pain; Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Appendicitis; Ceftazi	2003
Appendicitis in children: a ten-year update of therapeutic recommendations. Journal of pediatric surgery, 2003, Volume: 38, Issue:2 Topics: Abdominal Abscess; Acute Disease; Adolescent; Ampicillin; Antibiotic Prophylaxis; Appendectomy; Appe	2003
Acute appendicitis with fulminant necrotizing fasciitis in a neonate. Journal of pediatric surgery, 2003, Volume: 38, Issue:11 Topics: Acute Disease; Appendectomy; Appendicitis; Clindamycin; Combined Modality Therapy; Debridement; Drug	2003
Comparative study of mezlocillin in combination with metronidazole in patients with perforation of the inflamed appendix. Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl Topics: Anti-Infective Agents; Appendectomy; Appendicitis; Bacteria; Bacterial Infections; Controlled Clinic	1989
Role of interval appendectomy in the management of complicated appendicitis in children. World journal of surgery, 2006, Volume: 30, Issue:1 Topics: Adolescent; Anti-Infective Agents; Appendectomy; Appendicitis; Child; Child, Preschool; Humans; Infa	2006
A simple and more cost-effective antibiotic regimen for perforated appendicitis. Journal of pediatric surgery, 2006, Volume: 41, Issue:5 Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Appendicitis; Ceftriaxone; Child; Child,	2006
Acute isolated tuberculous appendicitis. Journal of clinical pharmacy and therapeutics, 2006, Volume: 31, Issue:3 Topics: Adult; Amikacin; Antibiotics, Antitubercular; Antitubercular Agents; Appendicitis; Appendix; Female;	2006
Are routine peritoneal fluid cultures during appendicectomy justified? Irish journal of medical science, 2007, Volume: 176, Issue:1 Topics: Abdominal Abscess; Abdominal Cavity; Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxi	2007
Clinical challenges and images in GI. Amoebic appendicitis. Gastroenterology, 2007, Volume: 133, Issue:5 Topics: Adult; Amebiasis; Amoeba; Animals; Antiprotozoal Agents; Appendicitis; Appendix; Dysentery, Amebic;	2007
Amebiasis presenting as acute appendicitis. Southern medical journal, 2007, Volume: 100, Issue:11 Topics: Adult; Amebiasis; Antiprotozoal Agents; Appendectomy; Appendicitis; Diagnosis, Differential; Humans;	2007
Amebic appendicitis associated with hepatic abscess. Southern medical journal, 1984, Volume: 77, Issue:8 Topics: Amebiasis; Appendectomy; Appendicitis; Entamoeba histolytica; Entamoebiasis; Humans; Liver Abscess,	1984
Antibiotic peritoneal lavage in childhood appendicitis. Journal of the Royal College of Surgeons of Edinburgh, 1984, Volume: 29, Issue:5 Topics: Adolescent; Appendectomy; Appendicitis; Cephaloridine; Child; Child, Preschool; Drug Therapy, Combin	1984
[Metronidazole in the treatment of peritonitis of appendiceal origin]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1984, Volume: 63, Issue:8-9 Topics: Appendicitis; Humans; Metronidazole; Peritonitis	1984
[Treatment with metronidazole in patients with destructive appendicitis]. Khirurgiia, 1983, Issue:9 Topics: Adult; Aged; Appendicitis; Female; Humans; Male; Metronidazole; Middle Aged; Peritonitis; Suppuratio	1983
Appendicitis. Australian family physician, 1983, Volume: 12, Issue:7 Topics: Adolescent; Adult; Aged; Appendicitis; Cephalosporins; Child; Diagnosis, Differential; Female; Human	1983
The influence of metronidazole prophylaxis and the method of closure on wound infection in non-perforating appendicitis in childhood. Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1983, Volume: 38, Issue:5 Topics: Appendectomy; Appendicitis; Humans; Metronidazole; Prospective Studies; Random Allocation; Surgical	1983
Effect of metronidazole and ampicillin on patients with gangrenous or perforated appendicitis. A comparative study. Scandinavian journal of infectious diseases. Supplementum, 1981, Volume: 26 Topics: Adolescent; Adult; Aerobiosis; Aged; Ampicillin; Anaerobiosis; Appendicitis; Bacteria; Female; Gangr	1981
[Metronidazole in perforated appendicitis. A retrospective study on the effect of metronidazole administered peroperatively]. Ugeskrift for laeger, 1982, Jan-04, Volume: 144, Issue:1 Topics: Adolescent; Adult; Aged; Appendectomy; Appendicitis; Bacterial Infections; Child; Child, Preschool;	1982
Perforated appendicitis in children: use of metronidazole for the reduction of septic complications. Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1981, Volume: 32, Issue:2 Topics: Adolescent; Appendectomy; Appendicitis; Bacterial Infections; Child; Child, Preschool; Humans; Infan	1981
Metronidazole and appendicitis. Can a preoperative prophylaxis be changed to a peroperative treatment in high risk patients? Acta chirurgica Scandinavica, 1981, Volume: 147, Issue:6 Topics: Adolescent; Adult; Appendectomy; Appendicitis; Child; Drug Administration Schedule; Female; Humans;	1981
Antibiotic treatment for gangrenous and perforated appendix. British medical journal, 1980, Mar-15, Volume: 280, Issue:6216 Topics: Appendicitis; Gangrene; Humans; Intestinal Perforation; Metronidazole; Surgical Wound Infection	1980
Antibiotics in appendicectomy. British medical journal, 1980, Mar-15, Volume: 280, Issue:6216 Topics: Appendicitis; Drug Therapy; Humans; Metronidazole; Surgical Wound Infection	1980
Pre- and postoperative rectal metronidazole for the prevention of wound infection in childhood appendicitis. Journal of pediatric surgery, 1980, Volume: 15, Issue:2 Topics: Appendicitis; Child; Humans; Metronidazole; Postoperative Care; Preoperative Care; Suppositories; Su	1980
Management of appendicular mass in children. Annals of tropical paediatrics, 1993, Volume: 13, Issue:4 Topics: Ampicillin; Appendectomy; Appendicitis; Child; Drug Therapy, Combination; Female; Follow-Up Studies;	1993
Antimicrobial susceptibility patterns and resistance transferability among Bacteroides fragilis group isolates from patients with appendicitis in Bali, Indonesia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1993, Volume: 16, Issue:4 Topics: Acute Disease; Anti-Bacterial Agents; Appendicitis; Bacteroides fragilis; Chloramphenicol Resistance	1993
[Treatment of appendiceal peritonitis]. Khirurgiia, 1996, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoglycosides; Anti-Bacterial Agents; Appendicitis; Ce	1996
In vitro antibiotic susceptibility of Bacteroides fragilis strains isolated from excised appendix of patients with phlegmonous or gangrenous appendicitis. Acta microbiologica Polonica, 2000, Volume: 49, Issue:2 Topics: Adult; Appendicitis; Appendix; Bacteroides fragilis; Child; Drug Resistance, Microbial; Humans; Metr	2000
Metronidazole-resistant Bacteroides from untreated patient. Lancet (London, England), 1979, Apr-14, Volume: 1, Issue:8120 Topics: Acute Disease; Appendicitis; Bacteroides fragilis; Child; Drug Resistance, Microbial; Humans; Intest	1979
Management of appendicitis. British medical journal, 1977, Jan-08, Volume: 1, Issue:6053 Topics: Appendicitis; Humans; Metronidazole; Surgical Wound Infection	1977
[Use of preventive intra-operative antibiotic administration in appendectomy. A pharmacokinetic study]. Zentralblatt fur Chirurgie, 1991, Volume: 116, Issue:13 Topics: Adipose Tissue; Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Appendectomy; Appendicitis;	1991
[Prophylactic administration of Klion in acute appendicitis]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1990, Volume: 69, Issue:8 Topics: Acute Disease; Appendicitis; Child; Female; Humans; Male; Metronidazole; Postoperative Complications	1990
[Antibiotic prevention in acute appendicitis]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1990, May-10, Volume: 110, Issue:12 Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Appendectomy; Appendicitis; Child; Ch	1990
Post-appendectomy wound infection, a solved problem? The Netherlands journal of surgery, 1989, Volume: 41, Issue:5 Topics: Acute Disease; Appendectomy; Appendicitis; Humans; Length of Stay; Metronidazole; Premedication; Sur	1989
[Pharmacological prevention of wound infection in children after appendectomy]. Khirurgiia, 1989, Issue:11 Topics: Acute Disease; Anti-Bacterial Agents; Appendectomy; Appendicitis; Bacterial Infections; Child; Femal	1989
Evaluation of the use of a protocol in the antimicrobial treatment of intra-abdominal sepsis. The Journal of hospital infection, 1985, Volume: 6, Issue:1 Topics: Adult; Anti-Bacterial Agents; Appendicitis; Bacteria; Drug Administration Schedule; Humans; Metronid	1985
[Long-term experience with rectal administration of metronidazole in the treatment of perforated appendicitis]. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1988, Volume: 67, Issue:7 Topics: Abdomen; Abscess; Adolescent; Adult; Appendicitis; Child; Female; Humans; Intestinal Perforation; Ma	1988
[Prevention of wound suppuration after appendectomy]. Vestnik khirurgii imeni I. I. Grekova, 1988, Volume: 141, Issue:9 Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Appendectomy; Appendicitis; Bacterial Infection	1988
[Metronidazole in the complex treatment of peritonitis of appendicular etiology in children]. Vestnik khirurgii imeni I. I. Grekova, 1987, Volume: 139, Issue:10 Topics: Appendicitis; Bacteroides fragilis; Bacteroides Infections; Child; Combined Modality Therapy; Escher	1987
[Effect of metronidazol on the postoperative course of acute appendicitis]. Harefuah, 1987, Volume: 113, Issue:1-2 Topics: Acute Disease; Appendicitis; Humans; Length of Stay; Methods; Metronidazole; Premedication; Surgical	1987
Abdominal actinomycosis. Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood, 1986, Volume: 41, Issue:4 Topics: Abscess; Actinomycosis; Appendectomy; Appendicitis; Child; Combined Modality Therapy; Humans; Male;	1986
[Effectiveness of rectal metromidazole in acute infantile appendicitis]. Anales espanoles de pediatria, 1986, Volume: 25, Issue:3 Topics: Administration, Rectal; Adolescent; Appendicitis; Bacterial Infections; Child; Child, Preschool; Dru	1986
The management of severe appendicitis in children. Annals of the Academy of Medicine, Singapore, 1985, Volume: 14, Issue:4 Topics: Acute Disease; Appendectomy; Appendicitis; Cefoxitin; Child; Drug Therapy, Combination; Humans; Metr	1985
Cutaneous amoebiasis. The Australian and New Zealand journal of surgery, 1973, Volume: 42, Issue:3 Topics: Adult; Amebiasis; Antiparasitic Agents; Appendicitis; Drainage; Emetine; Entamoeba histolytica; Huma	1973
[Significance of the treatment of trichomoniasis in gynecology and obstetrics]. Wiadomosci parazytologiczne, 1969, Volume: 15, Issue:3 Topics: Abortion, Spontaneous; Antiprotozoal Agents; Antitrichomonal Agents; Appendicitis; Female; Humans; M	1969

metronidazole and Appendicitis