histone deacetylase binding

Definition

Target type: molecularfunction

Binding to histone deacetylase. [GOC:jl]

Histone deacetylase (HDAC) binding is a critical molecular function involved in the regulation of gene expression. HDACs are enzymes that remove acetyl groups from lysine residues on histone proteins. Histone acetylation is a key epigenetic modification that can alter chromatin structure and accessibility, thereby influencing gene transcription.

HDAC binding proteins interact with HDACs, either directly or indirectly, to modulate their activity. These interactions can have a variety of effects on gene expression, including:

* **Repression of transcription:** HDACs typically promote gene silencing by removing acetyl groups from histones, leading to a more condensed chromatin structure that is less accessible to transcription factors. Binding proteins that enhance HDAC activity can therefore contribute to gene repression.
* **Activation of transcription:** In some cases, HDAC binding proteins can promote gene activation. This may occur through the recruitment of HDACs to specific genomic regions where they remove repressive histone modifications, allowing for the recruitment of transcriptional activators.
* **Modulation of HDAC activity:** HDAC binding proteins can also regulate the activity of HDACs by influencing their stability, localization, or interactions with other proteins. This can fine-tune the level of histone acetylation and gene expression in response to cellular signals.

The specific molecular function of HDAC binding is highly context-dependent and can vary depending on the specific proteins involved and the cellular environment. Understanding the molecular mechanisms underlying HDAC binding is essential for elucidating the complex interplay between histone modifications, chromatin structure, and gene expression.'
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Proteins (32)

Compounds (2,508)