metronidazole has been researched along with Malaria in 21 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Antipyrine and metronidazole were administered as a cocktail to young (4 weeks old) male Wistar rats (N = 12 for each treatment) to investigate the effect of malaria infection due to the rodent parasite Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of the two compounds in vivo." | 7.68 | Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat. ( Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO; Ward, SA, 1993) |
| "Antipyrine and metronidazole were administered as a cocktail to young (4 weeks old) male Wistar rats (N = 12 for each treatment) to investigate the effect of malaria infection due to the rodent parasite Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of the two compounds in vivo." | 3.68 | Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat. ( Edwards, G; Glazier, AP; Ismail, S; Kokwaro, GO; Ward, SA, 1993) |
| "The patient was initially treated for tetanus and aspiration pneumonia with a guarded prognosis." | 1.33 | Tetanus, pneumonia, and malaria in a tsunami victim in Banda Aceh, Indonesia. ( Hanley, MR; O'Regan, W; Squires, S; Tate, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (61.90) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghosh, S | 1 |
| Chan, JM | 1 |
| Lea, CR | 1 |
| Meints, GA | 1 |
| Lewis, JC | 1 |
| Tovian, ZS | 1 |
| Flessner, RM | 1 |
| Loftus, TC | 1 |
| Bruchhaus, I | 1 |
| Kendrick, H | 1 |
| Croft, SL | 1 |
| Kemp, RG | 1 |
| Kobayashi, S | 1 |
| Nozaki, T | 1 |
| Oldfield, E | 1 |
| Cross, RM | 1 |
| Flanigan, DL | 1 |
| Monastyrskyi, A | 1 |
| LaCrue, AN | 1 |
| Sáenz, FE | 1 |
| Maignan, JR | 1 |
| Mutka, TS | 1 |
| White, KL | 1 |
| Shackleford, DM | 1 |
| Bathurst, I | 1 |
| Fronczek, FR | 1 |
| Wojtas, L | 1 |
| Guida, WC | 1 |
| Charman, SA | 1 |
| Burrows, JN | 1 |
| Kyle, DE | 1 |
| Manetsch, R | 1 |
| Giannini, G | 1 |
| Battistuzzi, G | 1 |
| Vignola, D | 1 |
| Ocan, M | 1 |
| Bbosa, GS | 1 |
| Waako, P | 1 |
| Ogwal-Okeng, J | 1 |
| Obua, C | 1 |
| Hanley, MR | 1 |
| O'Regan, W | 1 |
| Squires, S | 1 |
| Tate, C | 1 |
| Raju, HS | 1 |
| Eyckmans, L | 1 |
| Trussell, RR | 1 |
| Beeley, L | 1 |
| Golledge, CL | 1 |
| Riley, TV | 1 |
| Kokwaro, GO | 1 |
| Ismail, S | 1 |
| Glazier, AP | 1 |
| Ward, SA | 1 |
| Edwards, G | 1 |
| Fossati, C | 1 |
| Takada, S | 1 |
| James, RF | 1 |
| Esposito, R | 1 |
| Pallangyo, KJ | 1 |
| Minjas, JN | 1 |
| Sarda, RK | 1 |
| Escario, JA | 1 |
| Igea, AM | 1 |
| Contreras, M | 1 |
| Martinez-Fernandez, AR | 1 |
| Claramunt, R | 1 |
| Lopez, C | 1 |
| Ellis, CJ | 1 |
| Most, H | 1 |
| Geddes, AM | 1 |
| Sirol, J | 1 |
| Vedy, J | 1 |
| Sabrié, A | 1 |
| Woodruff, AW | 1 |
3 reviews available for metronidazole and Malaria
| Article | Year |
|---|---|
Prescribing in pregnancy. Infestations.
Topics: Animals; Anthelmintics; Antiprotozoal Agents; Bephenium Compounds; Cestode Infections; Female; Fetus | 1981 |
[Treatment of intestinal parasitosis].
Topics: Amphotericin B; Anthelmintics; Bithionol; Cestode Infections; Chloroquine; Humans; Intestinal Diseas | 1975 |
Drug therapy. Treatment of common parasitic infections of man encountered in the United States. 2.
Topics: Amebiasis; Amebicides; Anthelmintics; Antimalarials; Antimony; Benzenesulfonates; Chloroquine; Clono | 1972 |
18 other studies available for metronidazole and Malaria
| Article | Year |
|---|---|
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Cell Line; Cricetinae; Diphosphonates; Entamoeba histo | 2004 |
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
Topics: Animals; Antimalarials; Humans; Inhibitory Concentration 50; Malaria; Mice; Microsomes, Liver; Paras | 2014 |
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Topics: Animals; Antimalarials; Cell Line, Tumor; Dipeptides; Disease Models, Animal; Histone Deacetylase In | 2015 |
Factors predicting home storage of medicines in Northern Uganda.
Topics: Acetaminophen; Adolescent; Adult; Anti-Infective Agents; Artemether, Lumefantrine Drug Combination; | 2014 |
Tetanus, pneumonia, and malaria in a tsunami victim in Banda Aceh, Indonesia.
Topics: Adult; Ceftriaxone; Diazepam; Disasters; Female; Humans; Indonesia; Malaria; Metronidazole; Pneumoni | 2006 |
Metronidazole in malaria.
Topics: Humans; Malaria; Metronidazole | 1983 |
Treatment of tropical diseases (malaria and amoebiasis).
Topics: Amebiasis; Chloroquine; Humans; Malaria; Metronidazole; Plasmodium falciparum | 1981 |
Clostridium difficile-associated diarrhoea after doxycycline malaria prophylaxis.
Topics: Adult; Clostridioides difficile; Clostridium Infections; Diarrhea; Doxycycline; Female; Humans; Mala | 1995 |
Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat.
Topics: Animals; Antipyrine; Body Temperature; Disease Models, Animal; Endotoxins; Fever; Lipopolysaccharide | 1993 |
[Drugs used against protozoan infections in man].
Topics: Amebiasis; Aminoquinolines; Antiprotozoal Agents; Humans; Malaria; Metronidazole; Pneumonia, Pneumoc | 1990 |
Malaria treated with emetine or metronidazole.
Topics: Emetine; Humans; Malaria; Metronidazole; Plasmodium falciparum; Plasmodium vivax | 1985 |
Emetine and metronidazole as antimalarial drugs.
Topics: Emetine; Humans; Malaria; Metronidazole | 1985 |
Metronidazole for falciparum malaria.
Topics: Child; Humans; Malaria; Metronidazole; Plasmodium falciparum; Time Factors | 1986 |
Antiparasitic activity of nine pyrazole derivatives against Trichomonas vaginalis, Entamoeba invadens and Plasmodium berghei.
Topics: Animals; Chloroquine; Entamoeba; Female; In Vitro Techniques; Malaria; Metronidazole; Mice; Plasmodi | 1988 |
Antiparasitic agents in pregnancy.
Topics: Amebiasis; Female; Helminthiasis; Humans; Malaria; Metronidazole; Parasitic Diseases; Pregnancy; Pre | 1986 |
Imported infections. Unexplained fever.
Topics: Africa; Asia; Brucellosis; Chloramphenicol; Chloroquine; Fever; Humans; Leishmaniasis, Visceral; Liv | 1974 |
[Noma or forgotten ugliness. Clinical study and pathogenesis apropos of 6 cases at Fort-Lamy (Chad)].
Topics: Anti-Bacterial Agents; Chad; Child; Child, Preschool; Female; Humans; Leishmaniasis, Mucocutaneous; | 1972 |
Current practice in tropical medicine.
Topics: Acute Kidney Injury; Amebiasis; Amebicides; Chloroquine; Cholera; Drug Resistance, Microbial; Hepati | 1969 |