metronidazole has been researched along with Parasite Infections in 27 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole is the treatment of choice for bacterial vaginosis and seems to be as effective as vancomycin for treatment of Clostridium difficile-related diarrhea and colitis." | 2.37 | Symposium on antimicrobial agents. Metronidazole. ( Edson, RS; Rosenblatt, JE, 1987) |
| "Parasitic diseases are still a major health problem in developing countries." | 1.37 | Antiprotozoal activity of proton-pump inhibitors. ( Castillo, R; Hernández-Campos, A; Hernández-Luis, F; Pérez-Villanueva, J; Romo-Mancillas, A; Yépez-Mulia, L, 2011) |
| " The results indicate that a predicted drug cumulation would occur in malnourished children with the ordinary dosage regimen (30 mg/kg/day)." | 1.29 | A new dosing regimen for metronidazole in malnourished children. ( Cravioto, J; Lares-Asseff, I; Pérez-Ortíz, B; Santiago, P, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (48.15) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prado-Prado, FJ | 1 |
| García-Mera, X | 1 |
| González-Díaz, H | 1 |
| Pérez-Villanueva, J | 1 |
| Romo-Mancillas, A | 1 |
| Hernández-Campos, A | 1 |
| Yépez-Mulia, L | 1 |
| Hernández-Luis, F | 1 |
| Castillo, R | 1 |
| Ang, CW | 1 |
| Jarrad, AM | 1 |
| Cooper, MA | 1 |
| Blaskovich, MAT | 1 |
| Leitsch, D | 1 |
| Kumar, S | 1 |
| Bains, T | 1 |
| Won Kim, AS | 1 |
| Tam, C | 1 |
| Kim, J | 1 |
| Cheng, LW | 1 |
| Land, KM | 1 |
| Debnath, A | 1 |
| Kumar, V | 1 |
| Martínez-Girón, R | 1 |
| van Woerden, HC | 1 |
| Bergquist, R | 1 |
| Dillingham, RA | 1 |
| Pinkerton, R | 1 |
| Leger, P | 1 |
| Severe, P | 1 |
| Guerrant, RL | 1 |
| Pape, JW | 1 |
| Fitzgerald, DW | 1 |
| Vicente, D | 1 |
| Pérez-Trallero, E | 2 |
| Iglesias, L | 1 |
| Lopriore, C | 1 |
| Guidoum, Y | 1 |
| Briend, A | 1 |
| Branca, F | 1 |
| Robbie, MO | 1 |
| Sweet, RL | 1 |
| Brard, M | 1 |
| de Longraye, J | 1 |
| Trussell, RR | 1 |
| Beeley, L | 1 |
| Barrett-Connor, E | 1 |
| Areekul, S | 1 |
| Viravan, C | 1 |
| Churdchu, K | 1 |
| CheermaKara, C | 1 |
| Lares-Asseff, I | 1 |
| Cravioto, J | 1 |
| Santiago, P | 1 |
| Pérez-Ortíz, B | 1 |
| Taylor, M | 1 |
| Pillai, G | 1 |
| Kvalsvig, JD | 1 |
| Vahlensieck, W | 1 |
| Coulaud, JP | 1 |
| Mechali, D | 1 |
| Piccione, E | 1 |
| Docampo, R | 1 |
| Moreno, SN | 1 |
| Hof, H | 1 |
| Rosenblatt, JE | 1 |
| Edson, RS | 1 |
| Ellis, CJ | 1 |
| Simmons, PD | 1 |
| Shlansky, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Antimicrobials and Carriage of Antimicrobial Resistance Amongst Hospitalised Children With Severe Acute Malnutrition[NCT02746276] | Phase 2 | 81 participants (Actual) | Interventional | 2016-04-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for metronidazole and Parasite Infections
| Article | Year |
|---|---|
Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases.
Topics: Animals; Anti-Infective Agents; Bacteria; Bacterial Infections; Communicable Diseases; Humans; Nitro | 2017 |
A review on metronidazole: an old warhorse in antimicrobial chemotherapy.
Topics: Anaerobiosis; Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Bacteria; Bacterial Infections; | 2019 |
Parasitic infections affecting the oral cavity.
Topics: Animals; Antiparasitic Agents; Entamoeba; Humans; Leishmaniasis; Metronidazole; Mouth Diseases; Para | 2009 |
[Tetracyclines, sulfonamides, and metronidazole].
Topics: Anti-Bacterial Agents; Antiparasitic Agents; Bacterial Infections; Contraindications; DNA Damage; Dr | 2010 |
[Tetracyclines, sulfonamides and metronidazole].
Topics: Anti-Infective Agents; Bacterial Infections; Contraindications; DNA Replication; Humans; Metronidazo | 2003 |
Metronidazole use in obstetrics and gynecology: a review.
Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Fem | 1983 |
Prescribing in pregnancy. Infestations.
Topics: Animals; Anthelmintics; Antiprotozoal Agents; Bephenium Compounds; Cestode Infections; Female; Fetus | 1981 |
Drugs for the treatment of parasitic infection.
Topics: Antimony; Bithionol; Chloroquine; Diethylcarbamazine; Humans; Mebendazole; Melarsoprol; Metronidazol | 1982 |
[Sexually transmitted parasitoses and mycoses].
Topics: Adolescent; Adult; Antifungal Agents; Antitrichomonal Agents; Ectoparasitic Infestations; Female; Hu | 1999 |
Free radical metabolism of antiparasitic agents.
Topics: Animals; Chemical Phenomena; Chemistry; Free Radicals; Hydrogen Peroxide; Macromolecular Substances; | 1986 |
[Antimicrobial therapy with nitroheterocyclic compounds, for example, metronidazole and nitrofurantoin].
Topics: Animals; Bacterial Infections; Humans; Metronidazole; Molecular Structure; Nitrofurantoin; Parasitic | 1988 |
Symposium on antimicrobial agents. Metronidazole.
Topics: Bacteroides Infections; Fusobacterium Infections; Gram-Negative Anaerobic Bacteria; Humans; Metronid | 1987 |
1 trial available for metronidazole and Parasite Infections
| Article | Year |
|---|---|
Spread fortified with vitamins and minerals induces catch-up growth and eradicates severe anemia in stunted refugee children aged 3-6 y.
Topics: Algeria; Analysis of Variance; Anemia, Iron-Deficiency; Body Height; Child; Child, Preschool; Double | 2004 |
14 other studies available for metronidazole and Parasite Infections
| Article | Year |
|---|---|
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitati | 2010 |
Antiprotozoal activity of proton-pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antiprotozoal Agents; Drug Design; Entamoeba histolytica; G | 2011 |
Highly Potent 1
Topics: Anaerobiosis; Antiprotozoal Agents; Entamoeba histolytica; Foodborne Diseases; Giardia lamblia; Huma | 2018 |
Bronchopulmonary lophomoniasis: emerging disease or unsubstantiated legend?
Topics: Animals; Antiprotozoal Agents; Eukaryota; Humans; Metronidazole; Parasitic Diseases; Respiratory Tra | 2014 |
High early mortality in patients with chronic acquired immunodeficiency syndrome diarrhea initiating antiretroviral therapy in Haiti: a case-control study.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents; Case- | 2009 |
[Flagyl].
Topics: Humans; Metronidazole; Parasitic Diseases; Trichomonas Infections | 1984 |
Cholinesterase activity after treatment with mebendazole, thiabendazole and metronidazole in patients with various parasitic diseases.
Topics: Benzimidazoles; Cholinesterases; Humans; Mebendazole; Metronidazole; Parasitic Diseases; Thiabendazo | 1982 |
A new dosing regimen for metronidazole in malnourished children.
Topics: Biotransformation; Child, Preschool; Computer Simulation; Female; Humans; Infant; Male; Metabolic Cl | 1993 |
Targeted chemotherapy for parasite infestations in rural black preschool children.
Topics: Albendazole; Antiparasitic Agents; Black or African American; Black People; Cestode Infections; Chil | 1995 |
[Metronidazole and its derivatives].
Topics: Animals; Bacterial Infections; Female; Humans; Metronidazole; Parasitic Diseases | 1979 |
[Problems of antiparasitic therapy in pregnancy].
Topics: Antiprotozoal Agents; Chloroquine; Female; Humans; Metronidazole; Parasitic Diseases; Pregnancy; Pre | 1988 |
Antiparasitic agents in pregnancy.
Topics: Amebiasis; Female; Helminthiasis; Humans; Malaria; Metronidazole; Parasitic Diseases; Pregnancy; Pre | 1986 |
Sexually transmitted diseases in homosexual men.
Topics: Anti-Bacterial Agents; Homosexuality; Humans; Male; Metronidazole; Parasitic Diseases; Sexually Tran | 1985 |
Treatment of common enteric parasites.
Topics: Amebiasis; Amoeba; Ascariasis; Benzenesulfonates; Bephenium Compounds; Feces; Hookworm Infections; H | 1974 |