metronidazole has been researched along with indomethacin in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.67) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 13 (43.33) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Farhat, M; George, RF; Girgis, AS; Katritzky, AR; Naumov, RN; Panda, SS | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Abdel-Maksoud, MS; Ali, EMH; Oh, CH | 1 |
| Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
| Alander, C; Kornman, KS; Nuki, K; Raisz, LG; Soskolne, WA | 1 |
| Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE | 1 |
| Deitch, E; Grisham, MB; Perry, MA; Sartor, RB; Specian, RD; Yamada, T | 1 |
| Arndt, H; Granger, DN; Grisham, MB; Palitzsch, KD | 1 |
| Davies, GR; Rampton, DS; Wilkie, ME | 1 |
| Davies, NM; Jamali, F | 1 |
| Ching, CK; Cho, CH; Chow, JY; Ko, JK; Lam, SK; Zhang, ST | 1 |
| Agostinho, CL; Buchpiguel, CA; Coelho, AM; Damião, AO; Garcez, AT; Laudanna, AA; Leite, AZ; Lopasso, FP; Lordello, ML; Machado, MC; Sipahi, AM | 1 |
| Ceuppens, JL; Colpaert, S; De Greef, B; Geboes, K; Liu, Z; Rutgeerts, P | 1 |
| Evans, SM; Whittle, BJ | 2 |
| Kumria, R; Sinha, VR | 1 |
| Sargent, J; Sohaey, R; Trivedi, N | 1 |
2 review(s) available for metronidazole and indomethacin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemistry, Pharmaceutical; Humans; Inflammation; Neoplasms; Pyrimidines; Structure-Activity Relationship | 2019 |
1 trial(s) available for metronidazole and indomethacin
| Article | Year |
|---|---|
Effects of metronidazole and misoprostol on indomethacin-induced changes in intestinal permeability.
Topics: Adult; Chromium Radioisotopes; Double-Blind Method; Edetic Acid; Female; Humans; Indomethacin; Intestinal Absorption; Male; Mannitol; Metronidazole; Middle Aged; Misoprostol; Permeability | 1993 |
27 other study(ies) available for metronidazole and indomethacin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates.
Topics: Animals; Anti-Inflammatory Agents; Indomethacin; Mesalamine; Metronidazole; Mice; Molecular Structure; Quantitative Structure-Activity Relationship; Stomach Ulcer | 2015 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |
Bone resorbing activity of gingiva from beagle dogs following metronidazole and indomethacin therapy.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Gingivitis; Indomethacin; Metronidazole; Periodontitis | 1981 |
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.
Topics: Adult; Body Weight; Constipation; Humans; Ileostomy; Indomethacin; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Intestine, Small; Male; Metronidazole | 1983 |
Mechanisms of acute and chronic intestinal inflammation induced by indomethacin.
Topics: Acute Disease; Animals; Bacteria; Bile; Chronic Disease; Disease Models, Animal; Enteritis; Indomethacin; Injections, Subcutaneous; Intestinal Mucosa; Intestines; Male; Metronidazole; Neutrophils; Permeability; Peroxidase; Rats; Rats, Sprague-Dawley; Sulfasalazine | 1993 |
Metronidazole inhibits leukocyte-endothelial cell adhesion in rat mesenteric venules.
Topics: Animals; Cell Adhesion; Endothelium, Vascular; Indomethacin; Injections, Subcutaneous; Leukocytes; Leukotriene B4; Male; Mesenteric Veins; Metronidazole; Rats; Venules | 1994 |
Pharmacological protection of NSAID-induced intestinal permeability in the rat: effect of tempo and metronidazole as potential free radical scavengers.
Topics: Administration, Oral; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cyclic N-Oxides; Edetic Acid; Flurbiprofen; Free Radical Scavengers; Indomethacin; Intestinal Absorption; Intestinal Mucosa; Isotope Labeling; Male; Metronidazole; Peritonitis; Permeability; Protein-Losing Enteropathies; Rats; Rats, Sprague-Dawley; Spin Labels; Stomach Ulcer | 1997 |
The vascular and glandular organoprotective properties of metronidazole in the rodent stomach.
Topics: Animals; Capillary Permeability; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Membrane Potentials; Metronidazole; Rabbits; Rats; Rats, Sprague-Dawley; Stomach; Stomach Diseases | 1997 |
Protective effect of metronidazole on uncoupling mitochondrial oxidative phosphorylation induced by NSAID: a new mechanism.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Indomethacin; Intestinal Mucosa; Male; Metronidazole; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Permeability; Rats; Rats, Wistar; Regression Analysis; Statistics, Nonparametric; Uncoupling Agents | 2001 |
Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aztreonam; Bacteria, Anaerobic; Crohn Disease; Disease Models, Animal; Drug Therapy, Combination; Female; Indomethacin; Inflammation; Interleukin-10; Metronidazole; Monobactams; Permeability; Rats; Rats, Wistar; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2001 |
Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs.
Topics: Ampicillin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Gentian Violet; Indomethacin; Intestinal Mucosa; Jejunum; Male; Metronidazole; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenazines; Polymyxin B; Rats; Rats, Wistar; Sulfones; Superoxide Dismutase; Superoxides | 2001 |
Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Capillary Permeability; Dexamethasone; Disease Models, Animal; Indomethacin; Inflammation; Intestines; Male; Metronidazole; Microcirculation; Multiple Organ Failure; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Specificity; Polymyxin B; Rats; Rats, Wistar; Serum Albumin, Radio-Iodinated; Sulfones | 2003 |
Polysaccharide matrices for microbially triggered drug delivery to the colon.
Topics: Animals; Anti-Bacterial Agents; Cecum; Colon; Drug Carriers; Galactans; In Vitro Techniques; Indomethacin; Mannans; Metronidazole; Plant Gums; Polysaccharides, Bacterial; Rats; Rats, Wistar; Solubility; Tablets, Enteric-Coated | 2004 |
Sonographic detection of an infected maternal urachal cyst during pregnancy.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteroidaceae Infections; beta-Lactamase Inhibitors; Biopsy; Ceftriaxone; Female; Humans; Indomethacin; Metronidazole; Mothers; Pregnancy; Pregnancy Complications, Infectious; Prevotella; Ultrasonography, Prenatal; Urachal Cyst; Urachus | 2018 |