metronidazole has been researched along with Neoplasm Metastasis in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of extragenitourinary malakoplakia, developing in a patient with a history of plasma cell myeloma, which clinically mimicked recurrent extramedullary myelomatous involvement." | 1.37 | Extragenitourinary malakoplakia in a patient with myeloma clinically mimicking extramedullary myelomatous disease. ( Cox, RM; El Jamal, SM; Lorsbach, RB; Malak, SF, 2011) |
| " While the in vitro studies failed to reveal any synergism between 5-FU and MND, pharmacokinetic evaluation revealed that 5-FU clearance was significantly reduced (26." | 1.27 | 5-Fluorouracil-metronidazole combination therapy in metastatic colorectal cancer. Clinical, pharmacokinetic and in vitro cytotoxicity studies. ( Ayoub, J; Bardakji, Z; Besner, JG; Jolivet, J; Langelier, Y, 1986) |
| "In combined treatment of the laryngeal cancer patients after a summary focal dose of 32 Gy and 1." | 1.27 | [The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer]. ( Andreev, VG; Mardynskiĭ, IuS, 1985) |
| "Recently the resection of pulmonary metastases combined with chemotherapy has increased the survival rate." | 1.26 | Radiation treatment of Ewing's sarcoma and osteogenic sarcoma. ( Jenkin, RD, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (69.23) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| El Jamal, SM | 1 |
| Malak, SF | 1 |
| Cox, RM | 1 |
| Lorsbach, RB | 1 |
| McCormack, E | 1 |
| Silden, E | 1 |
| West, RM | 1 |
| Pavlin, T | 1 |
| Micklem, DR | 1 |
| Lorens, JB | 1 |
| Haug, BE | 1 |
| Cooper, ME | 1 |
| Gjertsen, BT | 1 |
| Urtasun, RC | 1 |
| Band, P | 1 |
| Ferri, H | 1 |
| Rau, BK | 1 |
| Harikrishnan, KM | 1 |
| Krishna, S | 1 |
| Bilgrami, S | 1 |
| Pesanti, EL | 1 |
| Singh, NT | 1 |
| Cobb, RJ | 1 |
| Chen, LL | 1 |
| Synnott, V | 1 |
| Jenkin, RD | 1 |
| Frytak, S | 1 |
| Moertel, CH | 1 |
| Childs, DS | 1 |
| Sheldon, PW | 1 |
| Hill, SA | 1 |
| Peters, LJ | 1 |
| Fowler, JF | 1 |
| Adams, GE | 1 |
| Denekamp, J | 1 |
| Bardakji, Z | 1 |
| Jolivet, J | 1 |
| Langelier, Y | 1 |
| Besner, JG | 1 |
| Ayoub, J | 1 |
| Andreev, VG | 1 |
| Mardynskiĭ, IuS | 1 |
| Rustia, M | 1 |
| Shubik, P | 1 |
13 other studies available for metronidazole and Neoplasm Metastasis
| Article | Year |
|---|---|
Extragenitourinary malakoplakia in a patient with myeloma clinically mimicking extramedullary myelomatous disease.
Topics: Aged; Anti-Bacterial Agents; Cefepime; Cephalosporins; Escherichia coli Infections; Humans; Malacopl | 2011 |
Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer.
Topics: Animals; Anti-Infective Agents; Carbocyanines; Cell Line, Tumor; Cell Survival; Escherichia coli Pro | 2013 |
Tumor growth delay studies in patients with multiple metastatic nodules: practical difficulties.
Topics: Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Neoplasm Metastasis; Neoplasms; Regression | 1980 |
Nd-YAG laser therapy for palliation of obstructed colorectal carcinomas.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Fema | 1994 |
Spinal cord compression due to anaerobic vertebral osteomyelitis in a patient with metastatic prostate cancer.
Topics: Aged; Anti-Bacterial Agents; Bacteremia; Bacteroides fragilis; Bacteroides Infections; Humans; Lumba | 1995 |
Radiation treatment of Ewing's sarcoma and osteogenic sarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Lung Neoplasms; Methotrexate; | 1977 |
Neurologic toxicity associated with high-dose metronidazole therapy.
Topics: Adenocarcinoma; Aged; Animals; Dogs; Female; Humans; Metronidazole; Middle Aged; Neoplasm Metastasis | 1978 |
Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in mice.
Topics: Animals; Hypoxia; Metronidazole; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Exp | 1977 |
Modification of the radiocurability of a syngeneic murine squamous carcinoma by its site of growth, by electron-affinic drugs, and by ICRF 159.
Topics: Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Radiation; Female; Imidazoles; Metron | 1976 |
Radiosensitizers of hypoxic cells in solid tumors.
Topics: Animals; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Fast Neutrons; Mammary Neopl | 1976 |
5-Fluorouracil-metronidazole combination therapy in metastatic colorectal cancer. Clinical, pharmacokinetic and in vitro cytotoxicity studies.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Colonic Neoplasms; Femal | 1986 |
[The results of metronidazole use in radiation and combined treatment of patients with laryngeal cancer].
Topics: Adult; Combined Modality Therapy; Follow-Up Studies; Humans; Laryngeal Neoplasms; Laryngectomy; Metr | 1985 |
Induction of lung tumors and malignant lymphomas in mice by metronidazole.
Topics: Adenocarcinoma; Animals; Carcinogens; Female; Hodgkin Disease; Kidney; Lung Neoplasms; Male; Metroni | 1972 |