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metronidazole and Coagulation Disorders, Blood

metronidazole has been researched along with Coagulation Disorders, Blood in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Three patients with ulcerative colitis in the active stage demonstrated reduced levels of F XIII activity and F XIII subunit A (61 and 80."1.28Substitution of factor XIII: a therapeutic approach to ulcerative colitis. ( Classen, M; Gain, T; Heinmüller, M; Lorenz, R; Tornieporth, N, 1991)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Van den Berg, SA1
Verwer, PE1
Idema, RN1
Van Guldener, C1
Lorenz, R1
Heinmüller, M1
Classen, M1
Tornieporth, N1
Gain, T1

Other Studies

2 other studies available for metronidazole and Coagulation Disorders, Blood

ArticleYear
Transient cefuroxime/metronidazole treatment induced factor V antibodies.
    BMJ case reports, 2014, Aug-19, Volume: 2014

    Topics: Abdominal Abscess; Adult; Anti-Bacterial Agents; Antibodies; Blood Coagulation Disorders; Cefuroxime

2014
Substitution of factor XIII: a therapeutic approach to ulcerative colitis.
    Haemostasis, 1991, Volume: 21, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Blood Coagulation Disorders; Colitis, Ulcerative; Factor XIII; Facto

1991