metronidazole has been researched along with Coagulation Disorders, Blood in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three patients with ulcerative colitis in the active stage demonstrated reduced levels of F XIII activity and F XIII subunit A (61 and 80." | 1.28 | Substitution of factor XIII: a therapeutic approach to ulcerative colitis. ( Classen, M; Gain, T; Heinmüller, M; Lorenz, R; Tornieporth, N, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van den Berg, SA | 1 |
| Verwer, PE | 1 |
| Idema, RN | 1 |
| Van Guldener, C | 1 |
| Lorenz, R | 1 |
| Heinmüller, M | 1 |
| Classen, M | 1 |
| Tornieporth, N | 1 |
| Gain, T | 1 |
2 other studies available for metronidazole and Coagulation Disorders, Blood
| Article | Year |
|---|---|
Transient cefuroxime/metronidazole treatment induced factor V antibodies.
Topics: Abdominal Abscess; Adult; Anti-Bacterial Agents; Antibodies; Blood Coagulation Disorders; Cefuroxime | 2014 |
Substitution of factor XIII: a therapeutic approach to ulcerative colitis.
Topics: Adrenal Cortex Hormones; Adult; Blood Coagulation Disorders; Colitis, Ulcerative; Factor XIII; Facto | 1991 |