metronidazole has been researched along with Basedow Disease in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of isolated levothyroxine malabsorption in the course of chronic intestinal giardiasis, leading to severe hypothyroidism." | 7.69 | Chronic intestinal giardiasis with isolated levothyroxine malabsorption as reason for severe hypothyroidism--implications for localization of thyroid hormone absorption in the gut. ( Rose, F; Schlaghecke, R; Seppel, T, 1996) |
| "We report a case of isolated levothyroxine malabsorption in the course of chronic intestinal giardiasis, leading to severe hypothyroidism." | 3.69 | Chronic intestinal giardiasis with isolated levothyroxine malabsorption as reason for severe hypothyroidism--implications for localization of thyroid hormone absorption in the gut. ( Rose, F; Schlaghecke, R; Seppel, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seppel, T | 1 |
| Rose, F | 1 |
| Schlaghecke, R | 1 |
| Ramsay, ID | 1 |
| Portioli, I | 1 |
| Rocchi, F | 1 |
| Maraini, G | 1 |
| Pescatori, A | 1 |
3 other studies available for metronidazole and Basedow Disease
| Article | Year |
|---|---|
Chronic intestinal giardiasis with isolated levothyroxine malabsorption as reason for severe hypothyroidism--implications for localization of thyroid hormone absorption in the gut.
Topics: Antiprotozoal Agents; Female; Giardiasis; Graves Disease; Humans; Hypothyroidism; Intestinal Absorpt | 1996 |
Endocrine ophthalmopathy.
Topics: Adult; Female; Graves Disease; Humans; Metronidazole; Peripheral Nervous System Diseases | 1968 |
[On the anti-exophthalmic and anti-thyroid action of an imidazole derivative with trichomonacidal action: metronidazole].
Topics: Adolescent; Adult; Exophthalmos; Female; Graves Disease; Humans; Hyperthyroidism; Male; Metronidazol | 1968 |