metronidazole has been researched along with Bowel Incontinence in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results show a promising trend indicating that metronidazole might significantly improve flatus incontinence associated with SIBO and might be more successful in treating flatus incontinence than gas absorbents." | 5.24 | Efficacy of antibiotherapy for treating flatus incontinence associated with small intestinal bacterial overgrowth: A pilot randomized trial. ( Bridoux, V; Ducrotté, P; Gourcerol, G; Leroi, AM; Melchior, C; Quinton, JF, 2017) |
| "Episodic pouchitis is easily treated and causes minimum functional consequences, whereas chronic pouchitis increases defecation frequency and needs prolonged medication." | 1.30 | Functional results after restorative proctocolectomy complicated by pouchitis. ( Järvinen, H; Keränen, U; Luukkonen, P, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melchior, C | 1 |
| Gourcerol, G | 1 |
| Bridoux, V | 1 |
| Ducrotté, P | 1 |
| Quinton, JF | 1 |
| Leroi, AM | 1 |
| Mills, JP | 1 |
| Talati, NJ | 1 |
| Alby, K | 1 |
| Han, JH | 1 |
| Pomazkin, VI | 1 |
| Dignass, AU | 1 |
| Keighley, MR | 1 |
| Keränen, U | 1 |
| Luukkonen, P | 1 |
| Järvinen, H | 1 |
| Shetty, AK | 1 |
| Udall, J | 1 |
| Schmidt-Sommerfeld, E | 1 |
1 review available for metronidazole and Bowel Incontinence
| Article | Year |
|---|---|
["Pouchitis"; histology].
Topics: Crohn Disease; Diagnosis, Differential; Diarrhea; Fecal Incontinence; Humans; Ileitis; Ileum; Inflam | 1993 |
1 trial available for metronidazole and Bowel Incontinence
| Article | Year |
|---|---|
Efficacy of antibiotherapy for treating flatus incontinence associated with small intestinal bacterial overgrowth: A pilot randomized trial.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Breath Tests; Charcoal; Drug Administratio | 2017 |
5 other studies available for metronidazole and Bowel Incontinence
| Article | Year |
|---|---|
The Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Colonization and Infection among Long-Term Acute Care Hospital Residents.
Topics: Aged; Anti-Bacterial Agents; Carbapenems; Carrier State; Case-Control Studies; Drug Resistance, Bact | 2016 |
[Results of one-stage reconstruction of anal sphincter in surgical treatment of fistulas-in-ano combined with fecal incontinence].
Topics: Adult; Anal Canal; Antibiotic Prophylaxis; Ceftriaxone; Fecal Incontinence; Female; Follow-Up Studie | 2011 |
[Management of perianal fistulizing Crohn's disease: a conservative approach].
Topics: Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Crohn Disease; Fecal Incontinence; | 2005 |
Functional results after restorative proctocolectomy complicated by pouchitis.
Topics: Adolescent; Adult; Aged; Anal Canal; Anastomosis, Surgical; Case-Control Studies; Chronic Disease; C | 1997 |
Highly destructive perianal Crohn's disease.
Topics: Adolescent; Anti-Infective Agents; Anti-Inflammatory Agents; Anus Diseases; Ciprofloxacin; Colostomy | 1998 |