Compound Depressed Skull Fracture

A skull fracture characterized by inward depression of a fragment or section of cranial bone, often compressing the underlying dura mater and brain. Depressed cranial fractures which feature open skin wounds that communicate with skull fragments are referred to as compound depressed skull fractures.

Synonyms(5)

Synonym
Skull Fracture, Depressed
Compound Depressed Skull Fracture
Compound Depressed Skull Fractures
Skull Fractures, Compound Depressed
Skull Fracture, Compound Depressed

Research Excerpts

Treatment

Excerpt	Reference
"Using dissociate bone flap to treat the mocrosis depressed skull fracture on the frontal and orbit part can avoid the complication of the traditional operation, and make the method become a plastic surgical operation."	( Ding, S; Luo, JM; Xiang, ZX; Xie, ZY; Zhuang, MH, 2005)

Research

Studies (24)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	11 (45.83)	18.1394
2010's	11 (45.83)	28.8240
2020's	2 (8.33)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	3
dalteparin	low	1
methanol	low	1
baclofen	low	1
isoflurane	low	1
metronidazole	low	1
urethane	low	1
durapatite	low	2
vancomycin	low	1
titanium	low	8
propiconazole	low	3
cefotiam	low	1

Protein Targets (299)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	3	0	0	3
GALC protein	1	0	0	1
GLI family zinc finger 3	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
glucocorticoid receptor [Homo sapiens]	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
retinoid X nuclear receptor alpha	4	0	0	4
estrogen-related nuclear receptor alpha	2	0	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	1	0	0	1
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
Bloom syndrome protein isoform 1	2	0	0	2
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
geminin	3	0	0	3
peripheral myelin protein 22	1	0	0	1
survival motor neuron protein isoform d	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	1	1	0	2
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	3	1	6
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	6	0	6
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	4	1	9
Carbonic anhydrase 2	0	4	1	8
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	3	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	3	1	4
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	1	0	2
Translocator protein	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	1	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	1	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	1	1	0	2
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	3	1	5
Carbonic anhydrase 6	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	1	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	1	1	0	2
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	1	0	2
Adenosine receptor A2a	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	3
Delta-type opioid receptor	0	2	0	3
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	3	1	7
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	3	0	3
Carbonic anhydrase 7	0	3	1	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	1	1	3
Gamma-aminobutyric acid receptor subunit beta-3	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-2	1	1	1	3
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	3	1	6
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	1	1	0	2
Canalicular multispecific organic anion transporter 1	0	3	0	3
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	2	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	1	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	6
phosphopantetheinyl transferase	2	0	0	2
ATAD5 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
AR protein	2	0	0	2
regulator of G-protein signaling 4	1	0	0	1
67.9K protein	1	0	0	1
activating transcription factor 6	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
lamin isoform A-delta10	2	0	0	2
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
ATP-dependent phosphofructokinase	1	0	0	1
RAR-related orphan receptor gamma	2	0	0	2
Cellular tumor antigen p53	4	0	0	4
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
thyroid stimulating hormone receptor	2	0	0	2
thyroid hormone receptor beta isoform 2	2	0	0	2
TDP1 protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
EWS/FLI fusion protein	1	0	0	1
pregnane X nuclear receptor	2	0	0	2
estrogen nuclear receptor alpha	4	0	0	4
Thioredoxin reductase	0	1	0	1
Histone H2A.x	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	1	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, Ferritin light chain	1	0	0	1
glp-1 receptor, partial	1	0	0	1
pregnane X receptor	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
progesterone receptor	1	0	0	1
nonstructural protein 1	1	0	0	1
farnesoid X nuclear receptor	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
chromobox protein homolog 1	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Glutamate receptor 2	1	0	0	1
Histamine H2 receptor	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Bile salt export pump	0	1	0	1
Albumin	0	1	1	2
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
15-lipoxygenase, partial	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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