Page last updated: 2024-09-28

Echinostomiasis

Infection by flukes of the genus Echinostoma.

Synonyms(1)

Synonym
Echinostomiasis

Research Excerpts

Overview

ExcerptReference
"Echinostomiasis is a food-borne intestinal, snail-mediated parasitosis caused principally by ingestion of snails infected with digenean trematodes of the Echinostoma genus."( Costa-Silva, M; Ferraz, J; Garcia, J; Lanfredi, R; Maldonado, A; Santana, A; Souza, J; Torres, E, 2012)
"Echinostomiasis is a food-borne, intestinal, zoonotic, snail-mediated helminthiasis caused by digenean trematodes of the family Echinostomatidae with seven species of the genus Echinostoma infecting humans or domestic and wildlife animals."( Carvalho, TM; de Souza, W; Gonçalves, JP; Maldonado Junior, A; Oliveira-Menezes, A, 2013)
"Echinostomiasis is one of the major food-borne trematodiases and the species Echinostoma caproni serves as a useful model for trematocidal drug discovery."( Ingram, K; Keiser, J; Panic, G, 2013)

Research

Studies (57)

TimeframeStudies, This Condition (%)All Conditions %
pre-19907 (12.28)23.3326
1990's19 (33.33)12.5806
2000's15 (26.32)18.1394
2010's15 (26.32)28.8240
2020's1 (1.75)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low20
dimethyl sulfoxide0low10
glycine0low10
albendazole0low10
atrazine0low20
chloroquine0low10
glyphosate0low10
ketotifen0low10
malathion0low10
mebendazole0low30
metronidazole0low10
praziquantel0low130
corticosterone0low10
prednisolone0low10
tyrosine0low10
adamantane0low20
thiazoles0low10
hydantoins0low10
oxyclozanide0low10
fluorescein-5-isothiocyanate0low10
rafoxanide0low20
arprinocid0low20
clorsulon0low20
artemisinin0low10
fibrinogen0low10
5,5-dimethyl-3-(alpha,alpha,alpha,4-tetrafluoro-3-tolyl)hydantoin0low10
cyanoginosin lr0low10
tacrolimus0low10
sesquiterpenes0low10
quinine0low10
tribendimidine0low20
beta carotene0low10
lutein0low10
methyl oleate0low10
selenium0low10
phosphatidylcholines0low10
heme0low10
transforming growth factor beta0low20
clothianidin0low10

Protein Targets (397)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Androgen receptor0303
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma9009
TDP1 protein150015
AR protein170017
nuclear receptor subfamily 1, group I, member 36006
cytochrome P450 family 3 subfamily A polypeptide 47007
glucocorticoid receptor [Homo sapiens]8008
estrogen-related nuclear receptor alpha110011
pregnane X nuclear receptor110011
estrogen nuclear receptor alpha160016
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
nuclear factor erythroid 2-related factor 2 isoform 25005
heat shock protein beta-16006
importin subunit beta-1 isoform 12002
snurportin-12002
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta107007
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump012012
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 24004
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 436006
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 57007
Ataxin-29009
Chain A, Beta-lactamase2002
Luciferase4004
glp-1 receptor, partial2002
hypoxia-inducible factor 1 alpha subunit5005
ATAD5 protein, partial1001
Fumarate hydratase2002
GLI family zinc finger 3110011
caspase 7, apoptosis-related cysteine protease1001
progesterone receptor6006
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha8008
farnesoid X nuclear receptor6006
polyprotein2002
67.9K protein2002
peroxisome proliferator activated receptor gamma9009
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
caspase-31001
IDH13003
euchromatic histone-lysine N-methyltransferase 26006
aryl hydrocarbon receptor8008
v-jun sarcoma virus 17 oncogene homolog (avian)4004
nuclear receptor subfamily 1, group I, member 24004
Histone H2A.x6006
cellular tumor antigen p53 isoform a2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
chromobox protein homolog 15005
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 2110011
histone deacetylase 9 isoform 32002
mitogen-activated protein kinase 14004
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
geminin8008
Vif0001
peripheral myelin protein 226006
survival motor neuron protein isoform d3003
muscleblind-like protein 1 isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A2002
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Interferon beta8008
Cellular tumor antigen p53100010
Integrin beta-31001
Integrin alpha-IIb1001
Methionine aminopeptidase0202
Fatty-acid amide hydrolase 10202
Inositol monophosphatase 13003
Canalicular multispecific organic anion transporter 10909
Chain A, Ferritin light chain2002
USP1 protein, partial4004
nonstructural protein 12002
nuclear factor erythroid 2-related factor 2 isoform 18008
Dihydroorotate dehydrogenase 0101
pregnane X receptor2002
GLS protein2002
peroxisome proliferator-activated receptor delta2002
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 13003
Nuclear receptor ROR-gamma3003
aldehyde dehydrogenase 1 family, member A16006
core protein, partial0101
histone acetyltransferase KAT2A isoform 13003
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10304
thioredoxin reductase3003
PPM1D protein3003
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0112
Replicase polyprotein 1ab0112
glucose-6-phosphate 1-dehydrogenase isoform b0101
flap endonuclease 12002
Transmembrane protease serine 20112
Dihydrofolate reductase 0101
DNA ligase0101
Riboflavin-binding protein0011
Major prion protein0011
Amyloid-beta precursor protein0101
Histidine-rich protein PFHRP-II0203
Procathepsin L0112
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40303
Cytochrome P450 3A40202
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0303
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Spike glycoprotein0101
Replicase polyprotein 1ab0213
Muscarinic acetylcholine receptor M10303
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0303
Alpha-2C adrenergic receptor0101
DNA ligase 10101
Muscarinic acetylcholine receptor M30303
Serine/threonine-protein kinase mTOR0202
Nuclear receptor subfamily 4 group A member 20011
Beta-secretase 10101
Spike glycoprotein4116
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0101
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20202
Sigma intracellular receptor 20101
Phosphoethanolamine N-methyltransferase0101
Sigma non-opioid intracellular receptor 10303
Angiotensin-converting enzyme 2 0112
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
acetylcholinesterase3003
Smad31001
EWS/FLI fusion protein5005
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
NFKB1 protein, partial1001
GALC protein2002
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
G3003
thyroid stimulating hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
thyroid hormone receptor beta isoform a4004
serine/threonine-protein kinase mTOR isoform 11001
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4004
Solute carrier family 22 member 20203
Solute carrier family 22 member 1 0404
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
HLA class I histocompatibility antigen, B alpha chain 3003
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0224
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10202
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Solute carrier family 22 member 10405
GABA theta subunit4004
Inositol hexakisphosphate kinase 13003
Gamma-aminobutyric acid receptor subunit epsilon4004
Solute carrier family 22 member 20404
cytochrome P450 2C9, partial3003
Tyrosine-protein phosphatase non-receptor type 10101
Protein phosphatase 1A0101
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit0101
Solute carrier organic anion transporter family member 1A20001
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform0101
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B 0101
Cereblon isoform 40202
Insulin-like growth factor-binding protein 50011
Choline O-acetyltransferase 0101
Protein cereblon0404
activating transcription factor 62002
thyrotropin-releasing hormone receptor1001
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0214
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0214
Glutamate receptor ionotropic, NMDA 2B0214
Glutamate receptor ionotropic, NMDA 2C0214
Large neutral amino acids transporter small subunit 10202
Glutamate receptor ionotropic, NMDA 2D0214
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0214
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0214
Sodium- and chloride-dependent glycine transporter 20101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
DNA polymerase beta1001
Glycogen synthase kinase-3 alpha0101
Glycogen synthase kinase-3 beta0101
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 42002
cytochrome P450 2D65005
arylsulfatase A2002
cytochrome P450 2D6 isoform 11001
hepatocyte nuclear factor 4-alpha isoform 20101
cytochrome P450 2C19 precursor1001
D(1A) dopamine receptor1001
perilipin-50101
perilipin-10101
potassium voltage-gated channel subfamily H member 2 isoform d1001
atrial natriuretic peptide receptor 2 precursor1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)2002
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Bile salt export pump0202
5-hydroxytryptamine receptor 40202
Glutathione reductase, mitochondrial0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Glucose-6-phosphate 1-dehydrogenase0101
5-hydroxytryptamine receptor 1A0202
D(1A) dopamine receptor0202
UDP-glucuronosyltransferase 1A40002
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Histamine H1 receptor0202
D(3) dopamine receptor0202
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 2B0202
Histamine H2 receptor2002
5-hydroxytryptamine receptor 60202
6-phosphogluconate dehydrogenase, decarboxylating0101
ATP-dependent phosphofructokinase3003
retinoic acid receptor alpha isoform 10101
retinoic acid receptor RXR-alpha isoform a0101
interleukin 81001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase1001
estrogen receptor 2 (ER beta)4004
vitamin D3 receptor isoform VDRA3003
nuclear factor NF-kappa-B p105 subunit isoform 11001
Carboxylic ester hydrolase 0101
SMAD family member 22002
SMAD family member 32002
cytochrome P450 2C9 precursor1001
huntingtin isoform 22002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Tyrosine-protein kinase ABL10202
Proto-oncogene tyrosine-protein kinase Src0202
Vascular endothelial growth factor receptor 20101
Disintegrin and metalloproteinase domain-containing protein 171001
Calmodulin-domain protein kinase 10101
Thioredoxin reductase 0101
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Lanosterol 14-alpha demethylase0101
Endoplasmic reticulum chaperone BiP0101
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b0011
Bloom syndrome protein isoform 12002
M-phase phosphoprotein 81001
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Cytochrome P450 2C9 0101
Glutamine synthetase0011
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
Solute carrier family 22 member 10101
Solute carrier organic anion transporter family member 1A40101
Solute carrier family 22 member 20101
Potassium channel subfamily K member 20101
Albumin0011
ATP-dependent translocase ABCB10203
Cytochrome P450 2D10101
Cytochrome P450 2D260101
Cytochrome P450 2D60202
Cytochrome P450 2D30101
5-hydroxytryptamine receptor 70101
Cytochrome P450 2D40101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
chaperonin-containing TCP-1 beta subunit homolog1001
TSHR protein1001
envelope glycoprotein0101
bromodomain adjacent to zinc finger domain 2B1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
serine/threonine-protein kinase PLK11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 12002
streptokinase A precursor0011
Rap guanine nucleotide exchange factor 31001
60 kDa heat shock protein, mitochondrial0101
10 kDa heat shock protein, mitochondrial0101
Guanine nucleotide-binding protein G1001
Thiosulfate sulfurtransferase0101
Chitinase0202
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Rap guanine nucleotide exchange factor 41001
Nuclear receptor subfamily 1 group I member 20011
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Polyphenol oxidase 20001
Carbonic anhydrase 120001
Carbonic anhydrase 10001
Carbonic anhydrase 20001
Plasma kallikrein0001
Carbonic anhydrase 30001
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Tubulin--tyrosine ligase0101
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Taste receptor type 2 member 140001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]