metronidazole has been researched along with Abnormalities, Autosome in 23 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Teratogenicity tests in animals have given negative results in the case of metronidazole, ornidazole and tinidazole, and in the case of metronidazole no evidence of any adverse effect on the outcome of pregnancy was seen in women treated for trichomoniasis at various times during gestation, including the first trimester." | 3.67 | Safety of nitroimidazoles. ( Roe, FJ, 1985) |
| "Chromosome studies were performed in bone-marrow cells from thirty nine patients with hepatic or intestinal amibiasis, and/or giardiasis, who had been treated with metronidazole during ten days." | 3.66 | Chromosome studies of bone marrow cells from metronidazole-treated patients. ( Armendares, S; Castaneda, G; Del C Santillan, M; Farfan, J; Munoz, O; Salamanca-Gomez, F, 1980) |
| "Metronidazole (MTZ) is an effective agent used in the treatment of parasitic infections." | 1.29 | Genotoxic effects of metronidazole. ( Elizondo, G; Gonsebatt, ME; Herrera, J; Hong, E; Lares, I; Ostrosky-Wegman, P; Salazar, AM; Santiago, P, 1996) |
| "Metronidazole was examined for cytogenicity in vivo and in vitro in mice and humans." | 1.26 | Metronidazole: absence of mammalian cytogenicity. ( Hartley-Asp, B, 1981) |
| " Dosage reduction was associated with exacerbation of disease activity in all patients, but in all, the perineal manifestations of disease healed promptly when the full dosage of metronidazole was reinstituted." | 1.26 | Metronidazole therapy for perineal Crohn's disease: a follow-up study. ( Bernstein, LH; Boley, SJ; Brandt, LJ; Frank, MS, 1982) |
| "Levamisole is a drug chemically related to metronidazole." | 1.26 | Levamisole does not produce chromosome fractures. ( Gómez-Estrada, H; Vázquez-Escobosa, C, 1981) |
| " Radiation dose-response curves for anoxic blood containing 8 mM metronidazole or misonidazole were compared with previously obtained curves for dicentric and total aberration induction in untreated anoxic blood." | 1.26 | The influence of two radiosensitizers on the induction of chromosome aberrations in human lymphocytes by X-radiation. ( Priseman, SJ; Prosser, JS, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (73.91) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das Roy, L | 1 |
| Giri, S | 1 |
| Singh, S | 1 |
| Giri, A | 1 |
| López Nigro, MM | 1 |
| Palermo, AM | 1 |
| Mudry, MD | 2 |
| Carballo, MA | 1 |
| el-Nahas, AF | 1 |
| el-Ashmawy, IM | 1 |
| Mitelman, F | 3 |
| Strömbeck, B | 2 |
| Ursing, B | 3 |
| Nordle, O | 1 |
| Hartley-Asp, B | 5 |
| Salamanca-Gomez, F | 2 |
| Castaneda, G | 2 |
| Farfan, J | 2 |
| Del C Santillan, M | 1 |
| Munoz, O | 2 |
| Armendares, S | 2 |
| Brandt, LJ | 1 |
| Bernstein, LH | 1 |
| Boley, SJ | 1 |
| Frank, MS | 1 |
| Lentze, MJ | 1 |
| Vázquez-Escobosa, C | 1 |
| Gómez-Estrada, H | 1 |
| Prosser, JS | 1 |
| Priseman, SJ | 1 |
| Korbelik, M | 1 |
| Horvat, D | 1 |
| Santillán, MC | 1 |
| Carballo, M | 1 |
| Labal de Vinuesa, M | 1 |
| Gonzalez Cid, M | 1 |
| Larripa, I | 1 |
| Ostrosky-Wegman, P | 2 |
| Gonsebatt, ME | 2 |
| Elizondo, G | 1 |
| Salazar, AM | 1 |
| Lares, I | 1 |
| Santiago, P | 1 |
| Herrera, J | 1 |
| Hong, E | 1 |
| Coulter, JR | 1 |
| Lambert, B | 1 |
| Lindblad, A | 1 |
| Ringborg, U | 1 |
| Chacko, M | 1 |
| Nagabhushan, M | 1 |
| Sarkar, S | 1 |
| Bhide, SV | 1 |
| Roe, FJ | 1 |
2 trials available for metronidazole and Abnormalities, Autosome
| Article | Year |
|---|---|
No cytogenic effect of metronidazole.
Topics: Chromosome Aberrations; Clinical Trials as Topic; Crohn Disease; Humans; Metronidazole; Random Alloc | 1980 |
Metronidazole exhibits no clastogenic activity in a double-blind cross-over study on Crohn's patients.
Topics: Adolescent; Adult; Chromosome Aberrations; Chromosomes; Crohn Disease; Female; Humans; Male; Metroni | 1982 |
21 other studies available for metronidazole and Abnormalities, Autosome
| Article | Year |
|---|---|
Effects of radiation and vitamin C treatment on metronidazole genotoxicity in mice.
Topics: Animals; Antioxidants; Ascorbic Acid; Chromosome Aberrations; Dose-Response Relationship, Drug; Dose | 2013 |
Cytogenetic evaluation of two nitroimidazole derivatives.
Topics: Adult; Antitrichomonal Agents; Cell Culture Techniques; Cell Division; Chromosome Aberrations; DNA D | 2003 |
Reproductive and cytogenetic toxicity of metronidazole in male mice.
Topics: Anemia; Animals; Anti-Infective Agents; Bone Marrow Cells; Chromosome Aberrations; Dose-Response Rel | 2004 |
Metronidazole: absence of mammalian cytogenicity.
Topics: Animals; Cell Survival; Chromatids; Chromosome Aberrations; Humans; Metronidazole; Mice; Mutagens; S | 1981 |
Chromosome studies of bone marrow cells from metronidazole-treated patients.
Topics: Adolescent; Bone Marrow; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human; Dysent | 1980 |
Metronidazole therapy for perineal Crohn's disease: a follow-up study.
Topics: Adult; Aged; Chromosome Aberrations; Crohn Disease; Drug Evaluation; Female; Follow-Up Studies; Huma | 1982 |
[Useful and superfluous measures in the treatment of infant diarrhea].
Topics: Bacterial Infections; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Diarrhea; Diar | 1982 |
Levamisole does not produce chromosome fractures.
Topics: Animals; Bone Marrow Cells; Chemical Phenomena; Chemistry; Chromosome Aberrations; Chromosomes; Leva | 1981 |
The influence of two radiosensitizers on the induction of chromosome aberrations in human lymphocytes by X-radiation.
Topics: Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Dose-Response Relationshi | 1980 |
The mutagenicity of nitroaromatic drugs: effect of metronidazole after incubation in hypoxia in vitro.
Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; Hypoxia; Lung; Metr | 1980 |
[Chromosomes in bone marrow cells of patients treated with metronidazole].
Topics: Bone Marrow; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human; Drug Evaluation; D | 1980 |
Mutagenic bioassay of certain pharmacological drugs: III. Metronidazole (MTZ).
Topics: Anaphase; Animals; Bone Marrow Cells; Cells, Cultured; CHO Cells; Chromosome Aberrations; Cricetinae | 1994 |
Environmental toxicants in developing countries.
Topics: Animal Population Groups; Animals; Antiparasitic Agents; Brain Diseases; Carcinogens; Chromosome Abe | 1996 |
Genotoxic effects of metronidazole.
Topics: Adolescent; Adult; Antitrichomonal Agents; Chromosome Aberrations; DNA Damage; Humans; Male; Metroni | 1996 |
Chromosome aberrations and metronidazole.
Topics: Chromosome Aberrations; Crohn Disease; Humans; Metronidazole; Mutagens | 1976 |
Mutagenicity of metronidazole.
Topics: Chromatids; Chromosome Aberrations; Drug Evaluation; Female; Humans; Metronidazole; Mutagens; Tricho | 1979 |
Mutagenicity of metronidazole.
Topics: Chromosome Aberrations; Humans; Lymphocytes; Metronidazole; Mutagens | 1979 |
Mutagenicity of metronidazole.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Metronidazole; Mice; Mutagens | 1979 |
Absence of genotoxic effects of metronidazole and two of its urinary metabolites on human lymphocytes in vitro.
Topics: Chromatids; Chromosome Aberrations; DNA Repair; Dose-Response Relationship, Drug; Humans; Lymphocyte | 1979 |
Studies on the possible mutagenic action of metronidazole.
Topics: Animals; Biotransformation; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Female; Metronidazole | 1987 |
Safety of nitroimidazoles.
Topics: Abnormalities, Drug-Induced; Animals; Chromosome Aberrations; Cricetinae; Dose-Response Relationship | 1985 |