Page last updated: 2024-09-27

Cecitis

Necrotizing inflammation of the CECUM (typhlon in Greek), sometimes spreading to the APPENDIX and/or the ILEUM. Symptoms include ABDOMINAL PAIN and DIARRHEA. Its pathogenesis is multifactorial. Typhlitis is often associated with NEUTROPENIA and chemotherapy in immunocompromised individuals (IMMUNOCOMPROMISED HOST).

Synonyms(3)

Synonym
Neutropenic Typhlitis
Cecitis
Typhlitis

Research Excerpts

Overview

Excerpt	Reference
"Typhlitis is a rare condition, characterized by necrotizing inflammation of the colon."	( Kerleau, JM; Levesque, H; Marie, I; Robaday, S; Tapon, E, 2008)
"Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia."	( Ardizzoni, A; Barili, MP; Bartolotti, M; Gelsomino, F; Tiseo, M, 2009)

Treatment

Excerpt	Reference
"Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia."	( Ardizzoni, A; Barili, MP; Bartolotti, M; Gelsomino, F; Tiseo, M, 2009)

Research

Studies (28)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (10.71)	23.3326
1990's	0 (0.00)	12.5806
2000's	9 (32.14)	18.1394
2010's	14 (50.00)	28.8240
2020's	2 (7.14)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
albendazole	low	1	0
acetovanillone	low	1	0
carmustine	low	1	0
ciprofloxacin	low	1	0
fluorouracil	low	1	0
isoflurane	low	1	0
mebendazole	low	1	0
metronidazole	low	1	0
propofol	low	1	0
sulfaguanidine	low	1	0
prednisolone	low	1	0
prednisone	medium	2	1
adenosine diphosphate	low	1	0
cytarabine	medium	3	1
podophyllotoxin	low	1	0
ethambutol	low	1	0
vancomycin	low	2	0
streptomycin	low	1	0
titanium	low	1	0
etoposide	medium	1	1
idarubicin	low	1	0
capecitabine	low	1	0
phosphoramidic acid	low	1	0
cephalosporin c	low	1	0
enrofloxacin	low	1	0
clarithromycin	low	1	0
nicotine	low	1	0
alanylglutamine	low	1	0
methotrexate	medium	1	1
meropenem	low	1	0
netilmicin	low	1	0
melphalan	low	1	0
amphotericin b	low	2	0
morphine	low	2	0
bismuth	low	1	0
arsenic	low	1	0
cefepime	low	1	0
1-(2-deoxy-beta-ribofuranosyl)-5-iodo-2-pyrimidinone	low	1	0
colistin	low	1	0
levoleucovorin	low	1	0
guanine	low	2	0
ganciclovir	low	1	0
pemetrexed	low	2	0
valganciclovir	low	1	0

Protein Targets (709)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
TDP1 protein	18	0	0	18
chromobox protein homolog 1	9	0	0	9
geminin	16	0	0	16
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	3	0	0	3
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	2	2	5
Delta-type opioid receptor	0	2	2	5
Kappa-type opioid receptor	0	2	2	5
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	5	0	0	5
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Luciferase	3	0	0	3
glp-1 receptor, partial	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
RAR-related orphan receptor gamma	12	0	0	12
ATAD5 protein, partial	6	0	0	6
Fumarate hydratase	4	0	0	4
GLI family zinc finger 3	12	0	0	12
AR protein	12	0	0	12
caspase 7, apoptosis-related cysteine protease	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	9	0	0	9
glucocorticoid receptor [Homo sapiens]	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	15	0	0	15
farnesoid X nuclear receptor	8	0	0	8
pregnane X nuclear receptor	10	0	0	10
estrogen nuclear receptor alpha	17	0	0	17
polyprotein	4	0	0	4
67.9K protein	6	0	0	6
peroxisome proliferator activated receptor gamma	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
caspase-3	4	0	0	4
IDH1	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Histone H2A.x	9	0	0	9
cellular tumor antigen p53 isoform a	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
transcriptional regulator ERG isoform 3	2	0	0	2
thyroid hormone receptor beta isoform 2	12	0	0	12
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	3	0	0	3
mitogen-activated protein kinase 1	4	0	0	4
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
Vif	0	0	0	1
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	7	0	0	7
muscleblind-like protein 1 isoform 1	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
lamin isoform A-delta10	14	0	0	14
neuropeptide S receptor isoform A	1	0	0	1
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	16
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	18	0	18
Interferon beta	9	0	0	9
Cellular tumor antigen p53	14	0	0	14
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Methionine aminopeptidase	0	2	0	2
Glutamate receptor 2	9	0	0	9
Fatty-acid amide hydrolase 1	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	16	0	17
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	10	0	0	10
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	2	0	0	2
interleukin 8	3	0	0	3
phosphopantetheinyl transferase	4	0	0	4
GLS protein	4	0	0	4
peroxisome proliferator-activated receptor delta	7	0	0	7
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 3A4	0	8	1	9
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	5	0	5
Cytochrome P450 2C19	0	3	0	3
Nuclear receptor ROR-gamma	4	0	0	4
Potassium voltage-gated channel subfamily H member 2	0	6	0	7
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Liver carboxylesterase 1	0	0	0	1
endonuclease IV	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
thyroid stimulating hormone receptor	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
EWS/FLI fusion protein	11	0	0	11
cytochrome P450 2D6	3	0	0	3
arylsulfatase A	5	0	0	5
Bloom syndrome protein isoform 1	5	0	0	5
peripheral myelin protein 22 isoform 1	3	0	0	3
thyroid hormone receptor beta isoform a	4	0	0	4
huntingtin isoform 2	4	0	0	4
nuclear receptor ROR-gamma isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	2	0	0	2
Bile salt export pump	0	3	0	3
Glutathione reductase, mitochondrial	0	1	0	1
Alpha-synuclein	1	0	0	1
Glutathione reductase	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	1	3
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Kappa-type opioid receptor	0	2	0	3
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	0	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	1	3
Metallo-b-lactamase	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase class B VIM-2	0	0	1	3
Beta-lactamase VIM-1	0	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
cytochrome P450 2C9 precursor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	4	2	1	7
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	2	1	11
Gamma-aminobutyric acid receptor subunit beta-1	4	2	1	7
Gamma-aminobutyric acid receptor subunit delta	4	2	1	7
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	1	7
DNA gyrase subunit A	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	1	7
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	1	7
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	1	7
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	4	2	1	7
Gamma-aminobutyric acid receptor subunit beta-3	4	2	1	7
Gamma-aminobutyric acid receptor subunit beta-2	4	2	1	7
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
GABA theta subunit	4	2	1	7
Gamma-aminobutyric acid receptor subunit epsilon	4	2	1	7
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
streptokinase A precursor	0	0	3	3
ATP-dependent translocase ABCB1	0	4	0	5
Solute carrier organic anion transporter family member 1B3	0	3	0	4
Solute carrier organic anion transporter family member 1B1	0	1	0	1
thioredoxin reductase	7	0	0	7
USP1 protein, partial	7	0	0	7
G	6	0	0	6
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase iota isoform a (long)	7	0	0	7
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	4	0	5
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	2	0	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
Microtubule-associated protein tau	5	0	0	5
nonstructural protein 1	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
TAR DNA-binding protein 43	5	0	0	5
Pantothenate synthetase	0	1	0	1
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
Prothrombin	0	1	0	2
Regulatory protein E2	0	0	2	2
ATP-dependent translocase ABCB1	0	2	0	2
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Tubulin beta-2B chain	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
acetylcholinesterase	2	0	0	2
Skn7p	0	0	0	1
pregnane X receptor	2	0	0	2
Thrombopoietin	1	0	0	1
estrogen receptor 2 (ER beta)	6	0	0	6
hemoglobin subunit beta	1	0	0	1
flap endonuclease 1	3	0	0	3
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	2	0	0	2
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Thymidine kinase	0	1	0	1
ClpP	2	0	0	2
NFKB1 protein, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
cytochrome P450 3A4 isoform 1	4	0	0	4
Solute carrier family 22 member 1	0	1	0	3
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	2
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	3	0	0	3
PPM1D protein	3	0	0	3
DNA polymerase III, partial	1	0	0	1
NPYLR7B	0	0	1	1
Parkin	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
D(1A) dopamine receptor	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
glucokinase regulatory protein	1	0	0	1
DNA polymerase beta	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase kappa isoform 1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
GALC protein	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Tyrosine-protein kinase ABL1	0	2	1	3
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Spike glycoprotein	5	0	0	5
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Calmodulin-domain protein kinase 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
15-lipoxygenase, partial	2	0	0	2
thioredoxin glutathione reductase	2	0	0	2
Smad3	2	0	0	2
glucocerebrosidase	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase	0	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
Thymidylate synthase	0	2	0	2
alpha-galactosidase	2	0	0	2
Thymidylate synthase	0	2	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Thymidylate synthase	0	3	0	3
Carbonic anhydrase 2	0	2	1	3
Thymidylate synthase	0	4	0	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	3	2	5
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	3	0	3
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	4	0	4
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	4	1	8
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	3	0	4
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	1	1	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Translocator protein	0	1	1	2
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	2	0	3
Kappa-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	2	5
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	2	1	4
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Thymidylate synthase	0	1	0	1
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Glucocorticoid receptor	0	5	2	12
Tubulin beta-4A chain	0	1	1	3
Prostaglandin G/H synthase 1	0	1	0	1
Tubulin beta chain	0	1	1	3
Tubulin alpha-3C chain	0	1	1	3
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Prostaglandin G/H synthase 2	0	1	0	1
Tubulin beta-3 chain	0	1	1	3
Tubulin beta-2A chain	0	1	1	3
Tubulin beta-8 chain	0	1	1	3
Calcium-activated potassium channel subunit alpha-1	0	1	0	1
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Carbonic anhydrase 1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Protein argonaute-2	0	0	1	1
Albumin	0	0	1	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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