Joint Loose Bodies

Fibrous, bony, cartilaginous and osteocartilaginous fragments in a synovial joint. Major causes are osteochondritis dissecans, synovial chondromatosis, osteophytes, fractured articular surfaces and damaged menisci.

Synonym
Loose Bodies, Joint
Joint Loose Bodies

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	4 (10.00)	23.3326
1990's	14 (35.00)	12.5806
2000's	10 (25.00)	18.1394
2010's	12 (30.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
homogentisic acid	low	1	0
acetaminophen	medium	1	1
pentetic acid	low	2	0
fluconazole	low	1	0
iohexol	low	1	0
metronidazole	low	1	0
zolpidem	medium	1	1
prednisone	low	1	0
penicillin g	low	1	0
3,3'-diaminobenzidine	low	1	0
tolonium chloride	low	1	0
meglumine	low	2	0
congo red	low	1	0
enbucrilate	low	1	0
gadolinium	low	5	0
calcium pyrophosphate	low	1	0
trolamine salicylate	low	12	0
keratan sulfate	low	1	0
pyrophosphate	low	1	0
amphotericin b	low	1	0
hydrocodone	medium	1	1
gadolinium dtpa	low	2	0
chlorhexidine	low	1	0
interleukin-8	low	1	0
transforming growth factor beta	low	2	0

Protein Targets (377)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Luciferase	5	0	0	5
RAR-related orphan receptor gamma	9	0	0	9
GLI family zinc finger 3	8	0	0	8
AR protein	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	5	0	0	5
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	8	0	0	8
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	7	0	0	7
estrogen nuclear receptor alpha	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
thyroid stimulating hormone receptor	5	0	0	5
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	5	0	0	5
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Cellular tumor antigen p53	8	0	0	8
Glutamate receptor 2	5	0	0	5
ATAD5 protein, partial	2	0	0	2
GLS protein	2	0	0	2
Microtubule-associated protein tau	1	0	0	1
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
chromobox protein homolog 1	2	0	0	2
thyroid hormone receptor beta isoform 2	6	0	0	6
peripheral myelin protein 22	6	0	0	6
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	2	0	6
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	1	0	1
Bile salt export pump	0	5	0	5
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	3	0	3
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	4	2	0	6
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	0	6
UDP-glucuronosyltransferase 1-6	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	0	6
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	0	6
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	0	0	1
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Cytochrome P450 2J2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-2	4	2	0	6
Carbonic anhydrase 9	0	1	0	1
GABA theta subunit	4	2	0	6
Canalicular multispecific organic anion transporter 1	0	4	0	4
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	2	0	6
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, Cruzipain	2	0	0	2
interleukin 8	2	0	0	2
phosphopantetheinyl transferase	3	0	0	3
peroxisome proliferator-activated receptor delta	3	0	0	3
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
lamin isoform A-delta10	7	0	0	7
Cytochrome P450 2C19	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
acid sphingomyelinase	1	0	0	1
acetylcholinesterase	5	0	0	5
PAX8	0	0	0	1
glp-1 receptor, partial	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
SMAD family member 2	1	0	0	1
USP1 protein, partial	2	0	0	2
SMAD family member 3	1	0	0	1
TDP1 protein	7	0	0	7
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
G	3	0	0	3
cytochrome P450 2D6	5	0	0	5
67.9K protein	1	0	0	1
glucocerebrosidase	1	0	0	1
Parkin	1	0	0	1
heat shock protein 90	0	0	1	1
caspase-3	1	0	0	1
IDH1	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	2	0	0	2
calcineurin A1, putative	0	0	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
perilipin-1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
huntingtin isoform 2	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	2	0	0	2
protein AF-9 isoform a	0	0	0	1
snurportin-1	1	0	0	1
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
geminin	5	0	0	5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA polymerase kappa isoform 1	1	0	0	1
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	2	2
lethal factor (plasmid)	1	0	0	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Integrin beta-3	2	0	0	2
72 kDa type IV collagenase	0	1	0	1
Integrin alpha-IIb	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Trypanothione reductase	0	1	0	1
Alpha-synuclein	1	0	0	1
Histamine H2 receptor	2	0	0	2
Spike glycoprotein	4	0	0	4
TAR DNA-binding protein 43	3	0	0	3
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
Multidrug and toxin extrusion protein 1	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Spermine oxidase	0	1	0	1
cytochrome P450 2C9, partial	3	0	0	3
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	1	0	2
Beta-lactamase	0	2	0	2
Amyloid-beta precursor protein	0	2	0	2
Beta-lactamase	0	0	0	2
5-hydroxytryptamine receptor 2A	0	0	0	1
Beta-galactosidase	0	1	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Histone deacetylase 3	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	1	3
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Thioredoxin reductase	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
endonuclease IV	1	0	0	1
GALC protein	1	0	0	1
nonstructural protein 1	1	0	0	1
arylsulfatase A	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
Microtubule-associated protein tau	0	2	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Albumin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Sodium-dependent dopamine transporter	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research

Studies (40)

Protein Targets (377)

Joint Loose Bodies

Synonyms(2)

Research

Studies (40)

Drugs Studied (32)

Protein Targets (377)