metronidazole has been researched along with Hidradenitis Suppurativa in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hidradenitis Suppurativa: A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ring, HC | 1 |
| Knudsen, A | 1 |
| Thomsen, SF | 1 |
| Ünal, E | 1 |
| Güvendi Akçınar, U | 1 |
| Arduç, A | 1 |
| Bettoli, V | 1 |
| Join-Lambert, O | 2 |
| Nassif, A | 2 |
| Coignard, H | 1 |
| Jais, JP | 1 |
| Guet-Revillet, H | 1 |
| Poirée, S | 1 |
| Fraitag, S | 1 |
| Jullien, V | 1 |
| Ribadeau-Dumas, F | 1 |
| Thèze, J | 1 |
| Le Guern, AS | 1 |
| Behillil, S | 1 |
| Leflèche, A | 1 |
| Berche, P | 1 |
| Consigny, PH | 1 |
| Lortholary, O | 1 |
| Nassif, X | 1 |
| Rayner, CR | 1 |
| Brook, I | 1 |
| Frazier, EH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicentric Randomized Double-Blind Phase 3 Trial Evaluating the Efficacy of an Adapted Antibiotherapy in Hurley Stage 2 Active Hidradenitis Suppurativa Patients Versus Tetracycline Derivative[NCT05821478] | Phase 3 | 92 participants (Anticipated) | Interventional | 2023-11-15 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Hidradenitis Suppurativa
| Article | Year |
|---|---|
Antibiotic Treatment of Hidradenitis Suppurativa.
Topics: Anti-Bacterial Agents; beta-Lactams; Ceftriaxone; Clindamycin; Drug Therapy, Combination; Ertapenem; | 2016 |
5 other studies available for metronidazole and Hidradenitis Suppurativa
| Article | Year |
|---|---|
Metronidazole for Hidradenitis Suppurativa: future potential treatment applications.
Topics: Hidradenitis Suppurativa; Humans; Metronidazole | 2021 |
Hidradenitis Suppurativa, Metabolic Syndrome, and Demodex spp. Infestation.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Anti-Bacterial Agents; Antiparasitic Agent | 2018 |
Efficacy of rifampin-moxifloxacin-metronidazole combination therapy in hidradenitis suppurativa.
Topics: Adult; Anti-Infective Agents; Antibiotics, Antitubercular; Aza Compounds; Drug Therapy, Combination; | 2011 |
Pathogenesis, clinical features and management of hidradenitis suppurativa.
Topics: Combined Modality Therapy; Hidradenitis Suppurativa; Humans; Metronidazole; Smoking Cessation | 1997 |
Aerobic and anaerobic microbiology of axillary hidradenitis suppurativa.
Topics: Adult; Aged; Anti-Bacterial Agents; Axilla; Bacteria, Aerobic; Bacteria, Anaerobic; Drainage; Female | 1999 |