metronidazole has been researched along with Arthritis, Rheumatoid in 25 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anecdotal reports suggest that metronidazole may have disease modifying activity in the treatment of rheumatoid arthritis." | 9.07 | Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. ( Capell, HA; Hunter, JA; Marshall, DA, 1992) |
| "Metronidazole was also prescribed because of possible Clostridium difficile-associated colitis." | 5.43 | Asymptomatic colitis induced by low-dose methotrexate. ( Fujita, Y; Ozeki, T, 2016) |
| "Anecdotal reports suggest that metronidazole may have disease modifying activity in the treatment of rheumatoid arthritis." | 5.07 | Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis. ( Capell, HA; Hunter, JA; Marshall, DA, 1992) |
| "Likewise, all three therapies attenuated alveolar bone loss." | 1.51 | Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss. ( Bull, J; Ebbers, MNB; Engelmann, R; Kneitz, S; Kreikemeyer, B; Lang, H; Lübcke, PM; Müller-Hilke, B; Volzke, J, 2019) |
| "Metronidazole was also prescribed because of possible Clostridium difficile-associated colitis." | 1.43 | Asymptomatic colitis induced by low-dose methotrexate. ( Fujita, Y; Ozeki, T, 2016) |
| "We report the first case of septic arthritis due to Prevotella bivia in a patient with severe, long-lasting rheumatoid arthritis (RA) treated with low doses of corticosteroids." | 1.31 | Septic arthiritis due to Prevotella bivia in a patient with rheumatoid arthritis. ( Alegre-Sancho, JJ; Juanola, X; Narvaez, FJ; Roig-Escofet, D, 2000) |
| "Gram-negative septic arthritis is an uncommon but serious complication of rheumatoid arthritis and is usually mono-articular." | 1.26 | Septic polyarthritis due to Bacteroides fragilis in a patient with rheumatoid arthritis. A case report. ( Pretorius, JA; Schorn, D, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (56.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lübcke, PM | 1 |
| Ebbers, MNB | 1 |
| Volzke, J | 1 |
| Bull, J | 1 |
| Kneitz, S | 1 |
| Engelmann, R | 1 |
| Lang, H | 1 |
| Kreikemeyer, B | 1 |
| Müller-Hilke, B | 1 |
| Lo Schiavo, A | 1 |
| Tirri, R | 1 |
| Peccerillo, F | 1 |
| Abbondanza, C | 1 |
| Russo, B | 1 |
| Caccavale, S | 1 |
| Ozeki, T | 1 |
| Fujita, Y | 1 |
| Zhang, X | 1 |
| Zhang, JC | 1 |
| Taylor, GK | 1 |
| Elliott, L | 1 |
| Sosin, MD | 1 |
| Soo, SS | 1 |
| Compaoré, C | 1 |
| Kemta Lekpa, F | 1 |
| Nebie, L | 1 |
| Niamba, P | 1 |
| Niakara, A | 1 |
| Jensen, SL | 1 |
| Amato, JE | 1 |
| Hartstein, ME | 1 |
| Breer, WA | 1 |
| Dodd, MJ | 1 |
| Griffiths, ID | 1 |
| Freeman, R | 1 |
| Drenick, EJ | 1 |
| Bassett, LW | 1 |
| Stanley, TM | 1 |
| Burnstein, SL | 1 |
| Liakos, S | 1 |
| Pybus, PK | 4 |
| Harkness, JA | 1 |
| Griffin, AJ | 1 |
| Heinrich, I | 1 |
| Gibson, T | 1 |
| Grahame, R | 1 |
| Wyburn-Mason, R | 1 |
| Schorn, D | 1 |
| Pretorius, JA | 1 |
| Cecchin, E | 1 |
| Zanello, F | 1 |
| De Marchi, S | 1 |
| Alegre-Sancho, JJ | 1 |
| Juanola, X | 1 |
| Narvaez, FJ | 1 |
| Roig-Escofet, D | 1 |
| Marshall, DA | 1 |
| Hunter, JA | 1 |
| Capell, HA | 1 |
| Lee, MG | 1 |
| Rawlins, SC | 1 |
| Didier, M | 1 |
| DeCeulaer, K | 1 |
| Golub, LM | 1 |
| McNamara, TF | 1 |
| D'Angelo, G | 1 |
| Greenwald, RA | 1 |
| Ramamurthy, NS | 1 |
| McDonald Scott, WA | 1 |
| Elsdon-Dew, R | 1 |
| Walker, AN | 1 |
| James, DG | 1 |
| Bailey, AR | 1 |
| Brunt, ME | 1 |
1 review available for metronidazole and Arthritis, Rheumatoid
| Article | Year |
|---|---|
The epidemiology of amoebiasis.
Topics: Africa; Amebiasis; Arthritis, Rheumatoid; Asia; Digestive System; Dysentery, Amebic; Entamoeba histo | 1968 |
2 trials available for metronidazole and Arthritis, Rheumatoid
| Article | Year |
|---|---|
A double-blind comparative study of metronidazole and placebo in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Humans; Metronidazole; | 1982 |
Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Male; Metronidazole; Middle | 1992 |
22 other studies available for metronidazole and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss.
Topics: Alveolar Bone Loss; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Chlorhe | 2019 |
Rosacea and abatacept: the first report of a possible correlation.
Topics: Abatacept; Anti-Bacterial Agents; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid | 2016 |
Asymptomatic colitis induced by low-dose methotrexate.
Topics: Aged; Anti-Infective Agents; Antibodies, Monoclonal, Humanized; Antidotes; Antirheumatic Agents; Art | 2016 |
[Combined therapy in a patient with generalized aggressive periodontitis and rheumatoid arthritis: a 15-year follow up case].
Topics: Adult; Aggressive Periodontitis; Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; | 2010 |
Complication of etanercept treatment for rheumatoid arthritis--purulent pericarditis caused by a commensal organism.
Topics: Aged; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; | 2012 |
Pentatrichomonas hominis infection in rheumatoid arthritis treated with adalimumab.
Topics: Adalimumab; Aged; Antibodies, Monoclonal, Humanized; Arthritis, Rheumatoid; Follow-Up Studies; Human | 2013 |
Bilateral periorbital necrotizing fasciitis.
Topics: Aged; Anti-Bacterial Agents; Arthritis, Rheumatoid; Bacteremia; Bronchopneumonia; Ceftriaxone; Debri | 2004 |
Pyogenic arthritis due to bacteroides complicating rheumatoid arthritis.
Topics: Aged; Arthritis, Infectious; Arthritis, Rheumatoid; Bacteroides fragilis; Bacteroides Infections; Fe | 1982 |
Rheumatoid arthritis associated with jejunoileal bypass.
Topics: Adult; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Ileum; Jejunum; Metronidazole | 1984 |
Parasitic rheumatism presenting as rheumatoid arthritis.
Topics: Adult; Amebiasis; Arthritis, Rheumatoid; Endolimax; Humans; Male; Metronidazole; Rheumatic Diseases; | 1983 |
Metronidazole in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Metronidazole | 1984 |
Acute intermittent porphyria.
Topics: Arthritis, Rheumatoid; Humans; Metronidazole | 1982 |
Metronidazole in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Metronidazole | 1982 |
Septic polyarthritis due to Bacteroides fragilis in a patient with rheumatoid arthritis. A case report.
Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Bacteroides fragilis; Bacteroides Infections; Female; | 1982 |
Treatment of cyclosporine-induced gingival hypertrophy.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Female; Gingival Hypertrophy; Huma | 1997 |
Septic arthiritis due to Prevotella bivia in a patient with rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Aged; Arthritis, Infectious; Arthritis, Rheumatoid; Bacteroidaceae Infectio | 2000 |
Infective arthritis due to Blastocystis hominis.
Topics: Adult; Arthritis, Infectious; Arthritis, Rheumatoid; Female; Humans; Intestinal Diseases, Parasitic; | 1990 |
A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity.
Topics: Animals; Arthritis, Rheumatoid; Cartilage, Articular; Diabetes Mellitus, Experimental; Humans; Male; | 1987 |
Herxheimer reactions in metronidazole treatment for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Metronidazole | 1987 |
Metronidazole for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Metronidazole | 1987 |
Metronidazole in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Humans; Metronidazole | 1985 |
Fresh drugs for old problems.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Azathioprine; Cephalosporins; Humans; Liver Abscess, | 1971 |