An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Reference |
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| "Serotonin syndrome is characterized by alterations in cognition, behavior, autonomic, and central nervous system function as a result of increased postsynaptic serotonin receptor agonism." | ( Gill, M; LoVecchio, F; Selden, B, 1999) |
| "The serotonin syndrome is a rare, but potentially fatal complication to treatment with serotonin reuptake inhibitors." | ( Apelland, T; Dietrichson, T; Gedde-Dahl, T, 1999) |
| "Serotonin syndrome is caused by drug induced excess of intrasynaptic 5-hydroxytryptamine." | ( Gillman, PK, 1999) |
| "Serotonin syndrome is an uncommon, serious adverse reaction that is usually associated with the interaction of two or more serotonergic agents." | ( Lee, CD; Lee, DO, 1999) |
| "The serotonin syndrome is characterized by a constellation of symptoms that include mental status changes, agitation, myoclonus, hyperreflexia, sweating, shivering, tremor, diarrhoea, lack of coordination, and fever." | ( Dunn, NR; Mackay, FJ; Mann, RD, 1999) |
| "Serotonin syndrome is an iatrogenic disorder induced by pharmacologic treatment with serotonergic agents that increases serotonin activity." | ( Ener, RA; Gallagher, RM; Meglathery, SB; Van Decker, WA, 2003) |
| "Serotonin syndrome is rarely reported in patients taking only one serotonergic medication." | ( Benitez, FL; Roth, BA; Shepherd, G; Velez, LI, 2004) |
| "Therefore, when serotonin syndrome is suspected, prompt discontinuation of the suspected causative medication, followed by close monitoring of the pharmacokinetics is warranted." | ( Katsu, H; Nakayama, K; Ochiai, Y; Okino, S; Wakutsu, N, 2003) |
| "Serotonin syndrome is a disorder resulting from excess stimulation of serotonin and is associated with drug interaction, single-drug therapy, and overdose." | ( Huang, CT; Liu, HW; Tsai, JH; Tseng, WP; Wu, MT, 2005) |
| "Serotonin syndrome is a rare but potentially fatal complication of drugs that have effects on central nervous system serotonin." | ( Likasitwattanakul, S, 2005) |
| "Serotonin syndrome is a serious adverse reaction usually due to interactions with serotonergic drugs." | ( Buckley, NA; Karunatilake, H, 2006) |
| "The serotonin syndrome is caused by a drug-induced increase of the intrasynaptic serotonin concentration." | ( Cassens, S; Neumann, P; Nickel, EA; Quintel, M, 2006) |
| "Serotonin syndrome is a potentially lethal adverse drug reaction that may occur in patients taking proserotoninergic medications." | ( Brown, DR; Keegan, MT; Rabinstein, AA, 2006) |
| "Serotonin syndrome is often described as a clinical triad of mental status changes, autonomic hyperactivity, and neuromuscular abnormalities, but not all of these findings are consistently present in all patients with the disorder." | ( Bush, E; Friedman, I; Miller, C, 2006) |
| "Serotonin syndrome is a potentially lethal pharmacodynamic interaction between medications that increase serotonergic transmission at the synaptic junction." | ( Ailawadhi, S; Baer, MR; Carlson, LA; Sung, KW, 2007) |
| "Serotonin syndrome is an under-reported and under-recognised condition that occurs on administration of selective serotonin re-uptake inhibitors alone, or in combination with other medication known to increase levels of 5-hydroxytryptamine." | ( Evans, CE; Sebastian, J, 2007) |
| "Serotonin syndrome is a rarely observed side-effect of Citalopram use." | ( Eraydin, I; Gunduz, A; Hos, U; Kalkan, A; Turedi, S, 2007) |
| "Serotonin syndrome is usually reported by the use of a combination of drugs." | ( Ghanizadeh, A; Ghanizadeh, M; Seifoori, M, 2008) |
| "Serotonin syndrome is suggested as one of the most probable diagnosis." | ( Ghanizadeh, A; Ghanizadeh, M; Seifoori, M, 2008) |
| "The serotonin syndrome is a rare toxicological emergency increasingly seen in emergency practice, secondary to increased use of proserotinergic drugs." | ( Day, LT; Jeanmonod, RK, 2008) |
| "The symptoms of serotonin syndrome are alteration of mental state, autonomic dysfunction, and neuromuscular disorders." | ( Carpenter, EC; Mason, LW; Randhawa, KS, 2008) |
| "MB-associated serotonin syndrome is an increasing and under recognized ('green') post-operative encephalopathy that warrants education to critical care neurologists and other physicians." | ( Casler, J; Festic, E; Freeman, WD; Riutort, K; Rowley, M; Shapiro, D, 2009) |
| "Serotonin syndrome is a potentially life-threatening condition that results from excessive serotonin agonism of the central and peripheral nervous system." | ( Ahned, N; Pearce, S; Varas, GM, 2009) |
| "Serotonin syndrome is a potentially life-threatening disorder of excessive serotoninergic activity often due to drug interactions." | ( Barriocanal, A; Costa, J; Isern, I; Montané, E; Parajon, T, 2009) |
| "Serotonin syndrome is rarely reported in patients taking sertraline in Japan." | ( Endou, M; Kan, R; Unno, Y, 2009) |
| "Serotonin syndrome is an iatrogenic disorder that results from serotonergic overactivity." | ( Wijdicks, EF; Yee, AH, 2010) |
| "The serotonin syndrome is a toxic state largely attributable to changes in sensitivity of serotonin receptor system in the brainstem and spinal cord resulting from increased serotonergic activity in central neurologic system, due to use of serotonergic agents either in overdose or in combination." | ( Erden Aki, SO; Sahiner, V, 2009) |
| "Serotonin syndrome is a potential side effect of some psychotropic medications in common use today." | ( Jensen, J; Lawyer, TI; Welton, RS, 2010) |
| "Serotonin syndrome is another adverse drug reaction leading to NMS associated with elevated serotonin." | ( Ariano, RE; Sokoro, AA; Zivot, J, 2011) |
| "Serotonin syndrome is caused by excess serotonin in the central nervous system." | ( Kostek, H; Kujawa, A; Majewska, M; Pyra, E; Szponar, J, 2011) |
| "Serotonin syndrome is described as a clinical triad of mental status changes, autonomic hyperactivity, and neuromuscular abnormalities." | ( Kant, S; Liebelt, E, 2012) |
| "Serotonin syndrome is another serious adverse effect that can potentially occur when using an MAOI with another drug that inhibits the reuptake of serotonin." | ( VanDenBerg, CM, 2012) |
| "Serotonin syndrome is a clinical diagnosis, which requires a high-index of diagnostic suspicion." | ( Exadaktylos, AK; Offinger, A; Weiler, S, 2013) |
| "Serotonin syndrome is gaining attention in perioperative and chronic pain settings due to the growing prevalence of multimodal therapies that increase serotonin levels and thereby heighten patient risk." | ( Beatty, NC; Curry, TB; Eisenach, JH; Langman, LJ; Nicholson, WT, 2013) |
| "Serotonin syndrome is elicited by excessive 5-HT in the brain (presynaptic mechanism), whereas syndrome intensity is attributed to neural circuits involving 5-HT2A and NMDA receptors (postsynaptic mechanism)." | ( Ma, Z; Rudacille, M; Tao, R; Zhang, G, 2014) |
| "Serotonin syndrome is a potentially life-threatening entity associated with pro-serotonergic medications in therapeutic use, in overdose, or when co-administered with other drugs." | ( Bosak, AR; Skolnik, AB, 2014) |
| "Serotonin syndrome is a potentially life-threatening condition that can be caused by administration of agents that increase serotonergic activity in the brain." | ( Chang, MC; Jang, SH; Kwon, YM, 2015) |
| "Serotonin syndrome is a potentially life-threatening adverse drug reaction that most commonly results from adverse interactions between drugs." | ( Ahad, A; Ayub, S; Ayub, Z; Shakoor, M, 2014) |
| "Serotonin syndrome is a drug-related toxicity caused by excess serotonin within the central nervous system." | ( Eguchi, S; Iwata, H; Kadono, T; Kaminaga, S; Kawano, T; Takahashi, T; Yamanaka, D; Yokoyama, M, 2015) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| "Serotonin syndrome is a rare but potentially fatal adverse drug reaction associated with increased serotonergic activity in the central nervous system." | ( Greenier, E; Lukyanova, V; Reede, L, 2014) |
| "Serotonin syndrome is a dangerous and rare complication of a pharmacotherapy and can lead to death." | ( Schenk, M; Wirz, S, 2015) |
| "Serotonin syndrome is a potentially life-threatening condition caused by excessive central and peripheral stimulation of serotonin brainstem receptors, usually triggered by inadvertent interactions between agents with serotonergic activity." | ( Abu Al-Robb, H; García-Torrecillas, JM; Mateo-Carrasco, H; Muñoz-Aguilera, EM, 2015) |
| "Although serotonin syndrome is an infrequent complication, it can be potentially life threatening." | ( Banks, J; Frykberg, RG; Gordon, S; Tierney, E, 2015) |
| "Serotonin syndrome is a potential adverse event associated with the use of SSRIs, the combination of SSRIs and trazodone, and the combination of SSRIs and linezolid." | ( Nguyen, T; Sin, B, 2015) |
| "Serotonin syndrome is a rare but potentially fatal complication of drugs that have effects on central nervous system serotonin." | ( Santimaleeworagun, W; Supasyndh, O; Suphanklang, J, 2015) |
| "Serotonin syndrome is a potentially life-threatening complication of serotonergic agents." | ( Ong, CT; Sung, SF; Tong, SH; Wu, CS, 2015) |
| "Serotonin syndrome is an increasingly common toxic syndrome in veterinary medicine with the availability of over-the-counter medications that alter serotonin metabolism." | ( Jennifer, H; Karyn, B; Mariana, P, 2017) |
| "Serotonin syndrome is believed to be due to excessive stimulation of 5-HT2A and 5-HT1A receptors, resulting in the clinical triad of altered mentation, autonomic instability and neuromuscular abnormalities." | ( Brooks, DE; Heise, CW; Malashock, H, 2017) |
| "BACKGROUND Serotonin syndrome is a condition characterized predominantly by neuromuscular symptoms and altered thermoregulation in response to serotonergic overtone." | ( Lin, CM; Little, K; Reynolds, PM, 2018) |
| "Although serotonin syndrome is infrequently encountered in obstetrics, it is paramount that all obstetricians are familiar with its recognition and management, particularly in community hospital settings." | ( Asusta, HB; Dominguez, P; Keyser, E; Miller, M; Odedokun, T, 2019) |
| "BACKGROUND Serotonin syndrome is a life-threatening condition that can lead to neurologic complications and is associated with the use of serotonergic medications." | ( Nookala, AU; Olatoye, OO; Pollard, EM; Smischney, NJ, 2018) |
| "Serotonin syndrome is a rare neuropsychiatric complication caused by serotonergic drugs." | ( Boesen, MS; Lindelof, M; Sagar, M, 2020) |
| "BACKGROUND Serotonin syndrome is a life-threatening condition that involves overstimulation serotonin receptors, which can be caused by medication overdose, drug-drug interactions, and regular doses of medications." | ( Arshad, W; Lim, R, 2020) |
| "Serotonin syndrome is due to excess serotonin in the nervous system." | ( Del Rosario, MM; Jamora, RDG; Suratos, CTR, 2020) |
| "Serotonin syndrome is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system." | ( Basta, MN, 2021) |
| "Serotonin syndrome is a rare but potentially life-threatening condition caused by excess serotonin in the central and peripheral nervous systems." | ( Loader, K, 2022) |
| "Serotonin syndrome is a potentially life-threatening condition resulting from a drug reaction that affects serotonin levels." | ( Huang, WH; Li, MJ, 2022) |