metronidazole has been researched along with Liver Diseases, Parasitic in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Liver Diseases, Parasitic: Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol." | 7.66 | Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. ( Daneshmend, TK; Elamin, AA; Homeida, M; Kaye, CM; Roberts, CJ, 1982) |
| "The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol." | 3.66 | Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis. ( Daneshmend, TK; Elamin, AA; Homeida, M; Kaye, CM; Roberts, CJ, 1982) |
| "In 7 metronidazole-treated hamsters, no obvious pathological damage was seen." | 1.29 | Monoclonal antibody-based immunohistochemical demonstration of Entamoeba histolytica in liver tissues of experimentally infected hamster (Mesocricetus auratus). ( Punpoowong, B; Riganti, M; Sherchand, JB; Thammapalerd, N; Tharavanij, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chatterjee, DK | 1 |
| Raether, W | 1 |
| Iyer, N | 1 |
| Ganguli, BN | 1 |
| Jaremin, B | 1 |
| Bielawska-Krasnowiecka, G | 1 |
| Daneshmend, TK | 1 |
| Homeida, M | 1 |
| Kaye, CM | 1 |
| Elamin, AA | 1 |
| Roberts, CJ | 1 |
| Sherchand, JB | 1 |
| Thammapalerd, N | 1 |
| Riganti, M | 1 |
| Tharavanij, S | 1 |
| Punpoowong, B | 1 |
| Uthman, SM | 1 |
| Powell, SJ | 1 |
| Wilmot, AJ | 1 |
| Elsdon-Dew, R | 1 |
6 other studies available for metronidazole and Liver Diseases, Parasitic
| Article | Year |
|---|---|
Caerulomycin, an antifungal antibiotic with marked in vitro and in vivo activity against Entamoeba histolytica.
Topics: 2,2'-Dipyridyl; Amebiasis; Animals; Antifungal Agents; Chemical Phenomena; Chemistry; Cricetinae; En | 1984 |
[2 cases of lambliasis, resistant to imidazole drugs, cured with atebrine].
Topics: Adolescent; Drug Resistance; Female; Giardia; Giardiasis; Humans; Liver Diseases, Parasitic; Male; M | 1983 |
Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Kinetics; Liver Cirrhosis; Liver Diseases, Parasi | 1982 |
Monoclonal antibody-based immunohistochemical demonstration of Entamoeba histolytica in liver tissues of experimentally infected hamster (Mesocricetus auratus).
Topics: Animals; Antibodies, Monoclonal; Cricetinae; Entamoeba histolytica; Entamoebiasis; Fluorescent Antib | 1994 |
Treatment of amebiasis.
Topics: Adolescent; Adult; Aged; Amebiasis; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn | 1974 |
The use of niridazole alone and in combination with other amoebicides in amoebic dysentery and amoebic liver abscess.
Topics: Amebicides; Anthelmintics; Chloroquine; Dysentery, Amebic; Electrocardiography; Emetine; Humans; Imi | 1969 |