Leishmaniasis, Mucocutaneous

A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms.

Synonym
Leishmaniasis, Mucocutaneous

Excerpt	Reference
"Mucocutaneous leishmaniasis is endemic in many areas of Central and South America and may occur in patients in the United States who have lived in or traveled to these areas."	( Armstrong, D; Jones, TC; Singer, C; Spiro, RH, 1975)
"Mucocutaneous leishmaniasis is a rare disease in Europe."	( Harto, A; Hilara, Y; Ledo, A; Miralles, ES; Moreno, R; Núñez, M, 1994)
"Mucocutaneous leishmaniasis is widely distributed in Brazil, with Leishmania (Viannia) braziliensis being the major etiologic agent."	( Amato , VS; Boulos, M; Duarte, MI; Neto, VA; Nicodemo, AC; Padilha, AR; Uip, DE; Valentini, M, 2000)
"Mucocutaneous leishmaniasis is a granulomatous disease clinically characterized by ulcerated skin and mucosal lesions whose clinical manifestations can regress spontaneously, but with possible long subclinical evolution."	( Arruda, D; Foss, NT; Motta, AC; Souza, CS, 2003)
"Mucocutaneous leishmaniasis is a serious preventable complication of cutaneous leishmaniasis."	( Figueroa, RA; Miranda, MC; Prager, M; Zea, DF, 2009)
"Mucocutaneous leishmaniasis is a granulomatous disease clinically characterized by ulcerated skin and mucosal lesions."	( Celine, MI; Joy, A; Karimbil, SK; Kumari, S, 2010)
"Mucocutaneous leishmaniasis is a rare disease in the Indian subcontinent, and clinicians from this region should have a high index of suspicion on encountering mucocutaneous ulcerative lesions."	( Celine, MI; Joy, A; Karimbil, SK; Kumari, S, 2010)
"Both cutaneous and mucocutaneous leishmaniasis are endemic in Northern Ethiopia."	( Abebe, Z; Dassoni, F; Morrone, A; Naafs, B, 2013)
"Mucosal or mucocutaneous leishmaniasis is the most severe form of tegumentary leishmaniasis due to its destructive character and potential damage to respiratory and digestive tracts."	( Alves, LL; Carvalho, JP; Cota, G; Freire, ML; Silva, SN; Souza, CSA, 2022)
"Mucosal or mucocutaneous leishmaniasis is the most severe form of tegumentary leishmaniasis due to its destructive character and potential damage to respiratory and digestive tracts."	( Alves, LL; Carvalho, JP; Cota, G; Freire, ML; Silva, SN; Souza, CSA, 2022)
"Mucosal or mucocutaneous leishmaniasis is the most severe form of tegumentary leishmaniasis due to its destructive character and potential damage to respiratory and digestive tracts."	( Alves, LL; Carvalho, JP; Cota, G; Freire, ML; Silva, SN; Souza, CSA, 2022)

Excerpt	Reference
"Cutaneous and mucocutaneous leishmaniasis affect a million people yearly, leading to skin lesions and potentially disfiguring mucosal disease."	( Bezemer, JM; de Vries, HJC; Limpens, J; Schallig, HDFH; van der Ende, J, 2021)

Excerpt	Reference
"Pentamidine isothionate is an effective treatment for mucocutaneous leishmaniasis, providing cure with a low rate of recurrence."	( Amato, J; Amato, V; Amato-Neto, V; Duarte, M; Nicodemo, A; Uip, D, 1998)
"Here we present a case of multiple treatment resistant mucocutaneous leishmaniasis with nasal involvement caused by L."	( Goyonlo, VM; Taghavi, F; Vahabi-Amlashi, S, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	123 (38.44)	23.3326
1990's	32 (10.00)	12.5806
2000's	46 (14.38)	18.1394
2010's	92 (28.75)	28.8240
2020's	27 (8.44)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	1	0
adenine	low	1	0
quinacrine	low	3	0
salicylic acid	low	1	0
formaldehyde	low	1	0
methanol	low	1	0
phosphorylcholine	medium	21	5
pteridines	low	1	0
pyrazinamide	low	1	0
1-anilino-8-naphthalenesulfonate	low	2	0
benzethonium	medium	1	1
berberine	low	1	0
butenafine	low	1	0
chloroquine	low	7	0
clofazimine	low	1	0
dapsone	low	1	0
eflornithine	low	1	0
ddt	low	3	0
furazolidone	low	1	0
gentamicin	low	1	0
indomethacin	low	1	0
iodoquinol	low	1	0
isoniazid	low	1	0
ketoconazole	medium	4	1
malathion	low	1	0
metronidazole	low	7	0
deet	low	1	0
pentamidine	medium	18	1
pentoxifylline	medium	8	2
primaquine	low	1	0
pyrimethamine	low	3	0
sulfamethoxazole	low	3	0
suramin	low	1	0
thalidomide	low	1	0
trimethoprim	low	3	0
prednisolone	low	4	0
sorbitol	low	8	0
thymidine	low	1	0
prednisone	low	2	0
leucine	low	1	0
dinitrofluorobenzene	low	1	0
triamcinolone acetonide	low	1	0
methylprednisolone	low	1	0
allylamine	low	1	0
thiazoles	low	2	0
plumbagin	low	1	0
emetine	low	3	0
copper gluconate	low	10	0
lucanthone hydrochloride	low	1	0
mannose	low	1	0
streptomycin	low	3	0
buthionine sulfoximine	low	1	0
dihydrostreptomycin sulfate	low	1	0
technetium	low	1	0
levamisole	low	1	0
permethrin	low	1	0
decamethrin	low	1	0
swainsonine	low	1	0
itraconazole	medium	9	2
imiquimod	low	1	0
chloroquine diphosphate	low	1	0
meglumine antimoniate	medium	66	6
fluorodeoxyglucose f18	low	1	0
tosyllysine chloromethyl ketone	low	1	0
4-aminopyrazolo(3,4-d)pyrimidine	low	1	0
methotrexate	low	3	0
n-methylglucosamine	low	1	0
methyl 5-aminolevulinate	low	1	0
paromomycin	medium	5	2
deoxycholic acid	low	5	0
cortisone	low	1	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
glucosamine	low	1	0
tartaric acid	low	1	0
inositol 3-phosphate	low	8	0
zithromax	low	1	0
8,8'-biplumbagin	low	1	0
stilbenes	low	1	0
nsc 4347	low	1	0
sesquiterpenes	low	1	0
curcumin	low	2	0
nadp	low	1	0
naphthoquinones	low	1	0
phenylephrine hydrochloride	low	14	0
hydroxystilbamidine	low	1	0
nerolidol	low	1	0
antimony	medium	70	3
arsenic	low	2	0
methylbenzethonium chloride	medium	1	1
proguanil	low	1	0
amphoglucamine	low	1	0
nifurtimox	low	3	0
mocetinostat	low	1	0
acid phosphatase	low	1	0
jaw	low	1	0
phosphatidylcholines	medium	1	1
tryparsamide	low	1	0
sodium nitrite	low	1	0
amphotericin b, deoxycholate drug combination	low	5	0
tetracycline	low	1	0
chlortetracycline	low	1	0
transforming growth factor beta	low	4	0
antimony potassium tartrate	low	1	0
sybr green i	low	1	0
pyrethrins	low	2	0
hyaluronoglucosaminidase	low	1	0
rifampin	low	4	0
allopurinol	medium	6	1
eye	low	1	0
concanavalin a	low	3	0
antimony sodium gluconate	medium	41	3

Protein Targets (1,055)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	4	0	0	4
thioredoxin reductase	16	0	0	16
USP1 protein, partial	17	0	0	17
TDP1 protein	34	0	0	34
vitamin D3 receptor isoform VDRA	16	0	0	16
importin subunit beta-1 isoform 1	7	0	0	7
flap endonuclease 1	13	0	0	13
serine/threonine-protein kinase PLK1	3	0	0	3
snurportin-1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	6	0	0	6
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	9	0	0	9
urokinase-type plasminogen activator precursor	10	0	0	10
plasminogen precursor	10	0	0	10
urokinase plasminogen activator surface receptor precursor	10	0	0	10
geminin	39	0	0	39
DNA polymerase kappa isoform 1	11	0	0	11
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	3	0	3
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	2	3
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	4	0	4
Leucine-rich repeat serine/threonine-protein kinase 2	0	4	0	4
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	18	0	0	18
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	26	0	0	26
AR protein	36	0	0	36
nuclear receptor subfamily 1, group I, member 3	22	0	0	22
cytochrome P450 family 3 subfamily A polypeptide 4	24	0	0	24
glucocorticoid receptor [Homo sapiens]	34	0	0	34
estrogen-related nuclear receptor alpha	33	0	0	33
pregnane X nuclear receptor	28	0	0	28
estrogen nuclear receptor alpha	47	0	0	47
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
heat shock protein beta-1	13	0	0	13
tumor susceptibility gene 101 protein	3	0	0	3
lamin isoform A-delta10	27	0	0	27
Voltage-dependent calcium channel gamma-2 subunit	17	0	0	17
Bile salt export pump	0	38	0	38
Cyclin-dependent kinase 1	0	2	0	2
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	17	0	0	17
TAR DNA-binding protein 43	14	0	0	14
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
ATPase family AAA domain-containing protein 5	11	0	0	11
Ataxin-2	14	0	0	14
interleukin 8	13	0	0	13
thyroid stimulating hormone receptor	17	0	0	17
estrogen receptor 2 (ER beta)	16	0	0	16
progesterone receptor	21	0	0	21
IDH1	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	33	0	0	33
Bloom syndrome protein isoform 1	7	0	0	7
transcriptional regulator ERG isoform 3	9	0	0	9
thyroid hormone receptor beta isoform 2	24	0	0	24
ras-related protein Rab-9A	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	32	0	0	32
survival motor neuron protein isoform d	10	0	0	10
ATP-binding cassette sub-family C member 3	0	26	0	26
Multidrug resistance-associated protein 4	0	26	0	28
Polyphenol oxidase 2	0	3	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	29	0	0	29
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	4	1	5
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Purine nucleoside phosphorylase	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	26	0	26
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
aldehyde dehydrogenase 1 family, member A1	23	0	0	23
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Chain A, Beta-lactamase	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
Chain A, Cruzipain	7	0	0	7
phosphopantetheinyl transferase	11	0	0	11
GLS protein	10	0	0	10
farnesoid X nuclear receptor	21	0	0	21
peroxisome proliferator-activated receptor delta	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	25	0	0	25
tumor necrosis factor	1	0	0	1
peripheral myelin protein 22	19	0	0	19
Cytochrome P450 1A2	0	7	0	7
Cytochrome P450 3A4	0	12	0	13
Cytochrome P450 2D6	0	6	0	6
Cytochrome P450 2C9	0	9	0	9
Cytochrome P450 2C19	0	6	0	6
Nuclear receptor ROR-gamma	13	0	0	13
Potassium voltage-gated channel subfamily H member 2	0	11	0	11
Aurora kinase B	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Chain A, Ferritin light chain	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	15	0	0	15
cytochrome P450 2D6 isoform 1	8	0	0	8
interferon gamma precursor	0	0	0	1
nuclear receptor ROR-gamma isoform 1	10	0	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Histamine H2 receptor	7	0	0	7
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Fumarate hydratase	5	0	0	5
PPM1D protein	8	0	0	8
Microtubule-associated protein tau	12	0	0	12
EWS/FLI fusion protein	14	0	0	15
polyprotein	5	0	0	5
cytochrome P450 3A4 isoform 1	15	0	0	15
Gamma-aminobutyric acid receptor subunit pi	15	0	0	15
Telomerase reverse transcriptase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	2	0	2
Interferon beta	20	0	0	20
Neuraminidase	0	1	0	1
Neuraminidase	0	1	0	1
Cholinesterase	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	15	0	0	15
Tyrosine-protein phosphatase non-receptor type 1	0	3	0	5
Gamma-aminobutyric acid receptor subunit delta	15	0	0	15
Gamma-aminobutyric acid receptor subunit gamma-2	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-5	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-3	15	0	0	15
Acetylcholinesterase	0	6	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-2	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-4	15	0	0	15
Gamma-aminobutyric acid receptor subunit gamma-3	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-6	15	0	0	15
Aldo-keto reductase family 1 member C3	0	3	0	3
Prolyl endopeptidase	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	15	0	0	15
Gamma-aminobutyric acid receptor subunit beta-3	15	0	0	15
Gamma-aminobutyric acid receptor subunit beta-2	15	0	0	15
Cholinesterase	0	3	0	3
Inositol monophosphatase 1	4	0	0	4
Cytochrome P450 1B1	0	3	0	3
GABA theta subunit	15	0	0	15
Gamma-aminobutyric acid receptor subunit epsilon	15	0	0	15
pregnane X receptor	11	0	0	11
GLI family zinc finger 3	33	0	0	33
aryl hydrocarbon receptor	17	0	0	17
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
thyroid hormone receptor beta isoform a	15	0	0	15
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	18	2	25
Glycine receptor subunit alpha-1	0	18	0	18
Glycine receptor subunit beta	0	18	0	18
Glycine receptor subunit alpha-2	0	18	0	18
Glycine receptor subunit alpha-3	0	18	0	18
ORF73	0	0	1	1
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	27	0	0	27
G	12	0	0	12
cytochrome P450 2D6	15	0	0	15
peroxisome proliferator activated receptor gamma	19	0	0	19
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	13	0	0	13
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Aldo-keto reductase family 1 member B1	0	10	0	10
Alpha-2A adrenergic receptor	0	11	0	11
Sodium-dependent noradrenaline transporter	0	10	0	10
Sodium-dependent serotonin transporter	0	8	0	8
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Inositol hexakisphosphate kinase 1	12	0	0	12
Sigma non-opioid intracellular receptor 1	0	3	0	3
cytochrome P450 2C9, partial	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	4	0	4
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	2	2
Amyloid-beta precursor protein	0	2	0	4
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	2	2	4
Muscarinic acetylcholine receptor M2	0	8	0	8
Muscarinic acetylcholine receptor M4	0	5	0	5
Muscarinic acetylcholine receptor M5	0	5	0	5
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	3	3	6
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	4	3	7
Muscarinic acetylcholine receptor M1	0	3	0	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Alpha-2B adrenergic receptor	0	5	0	5
Alpha-2C adrenergic receptor	0	5	0	5
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	3	0	3
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	2	0	2
Spike glycoprotein	12	1	2	15
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
endonuclease IV	4	0	0	4
acetylcholinesterase	7	0	0	7
GALC protein	4	0	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	9	0	9
67.9K protein	12	0	0	12
chromobox protein homolog 1	18	0	0	18
mitogen-activated protein kinase 1	6	0	0	6
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
streptokinase A precursor	0	0	4	4
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	0	2	2
ATP-dependent translocase ABCB1	0	6	1	8
5-hydroxytryptamine receptor 1A	0	0	1	1
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	0	2	2
dopamine D1 receptor	7	0	0	7
regulator of G-protein signaling 4	7	0	0	7
peripheral myelin protein 22 isoform 1	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
M-phase phosphoprotein 8	4	0	0	4
muscarinic acetylcholine receptor M1	4	0	0	4
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	4	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Luciferase	9	0	0	9
Nrf2	1	0	0	1
15-lipoxygenase, partial	7	0	0	7
hypoxia-inducible factor 1 alpha subunit	13	0	0	13
SMAD family member 2	8	0	0	8
ATAD5 protein, partial	11	0	0	11
SMAD family member 3	8	0	0	8
alkaline phosphatase, intestinal	0	1	0	1
thioredoxin glutathione reductase	6	0	0	6
Smad3	5	0	0	5
apical membrane antigen 1, AMA1	5	0	0	5
caspase 7, apoptosis-related cysteine protease	3	0	0	3
PINK1	1	0	0	1
glucocerebrosidase	6	0	0	6
Parkin	3	0	0	3
toll-like receptor 9	0	1	0	1
caspase-3	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
TPA: protein transporter TIM10	0	1	0	1
thyroid stimulating hormone receptor	9	0	0	9
activating transcription factor 6	11	0	0	11
thyrotropin-releasing hormone receptor	2	0	0	2
Histone H2A.x	10	0	0	10
lysosomal alpha-glucosidase preproprotein	5	0	0	5
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	7	0	0	7
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	1	0	1
huntingtin isoform 2	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	5	0	0	5
nuclear factor NF-kappa-B p105 subunit isoform 1	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
muscleblind-like protein 1 isoform 1	8	0	0	8
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
hypothetical protein SA1422	0	1	0	1
lethal factor (plasmid)	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Prostaglandin E synthase	0	2	0	2
Histone deacetylase 3	0	4	0	4
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Integrin beta-3	6	0	0	6
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	5
Heme oxygenase 1	0	2	0	2
Integrin alpha-IIb	6	0	0	6
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
60 kDa chaperonin	0	3	0	3
Microtubule-associated protein tau	0	1	0	2
60 kDa heat shock protein, mitochondrial	0	7	0	7
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	1	0	1
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Alpha-1B adrenergic receptor	0	6	0	6
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Amine oxidase [flavin-containing] A	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Heme oxygenase 2	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Amine oxidase [flavin-containing] B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Prostaglandin G/H synthase 2	0	5	1	6
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-synuclein	3	4	1	8
Alpha-1A adrenergic receptor	0	6	0	6
Glycogen synthase kinase-3 beta	0	1	0	1
Caspase-7	3	0	0	3
Histone deacetylase 4	0	3	0	3
10 kDa heat shock protein, mitochondrial	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	3	0	3
Histone acetyltransferase p300	0	3	0	3
Serine/threonine-protein kinase PAK 1	0	1	0	1
Histone deacetylase 1	0	5	0	5
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thiosulfate sulfurtransferase	0	4	0	4
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
60 kDa chaperonin	0	7	0	7
10 kDa chaperonin	0	7	0	7
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	5	0	5
CREB-binding protein	0	2	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	3	0	3
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Histone deacetylase 8	0	4	0	4
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	3	0	3
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
cytochrome P450 2C9 precursor	2	0	0	2
Bile salt export pump	0	8	0	8
Myeloperoxidase	0	2	0	2
Dihydrofolate reductase	0	8	0	9
5-hydroxytryptamine receptor 6	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Androgen receptor	0	8	0	8
Chain A, Odorant binding protein	0	0	1	1
Chain B, Odorant binding protein	0	0	1	1
Epidermal growth factor receptor	0	3	0	3
Vascular endothelial growth factor receptor 2	0	1	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
histone deacetylase 9 isoform 3	3	0	0	3
Ornithine decarboxylase	0	1	0	1
Mitochondrial 2-oxodicarboxylate carrier	0	1	0	1
NS5	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Glucose transporter	0	1	0	1
Serine hydrolase RBBP9	0	1	0	1
Hexose transporter 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	2
Dihydroorotate dehydrogenase	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	2
exodeoxyribonuclease V subunit RecD	0	2	0	2
exodeoxyribonuclease V subunit RecB	0	2	0	2
exodeoxyribonuclease V subunit RecC	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	6	0	8
Solute carrier organic anion transporter family member 1B1	0	6	0	7
Vpr	2	0	0	2
Solute carrier family 22 member 2	0	2	0	2
Cytochrome P450 2B1	0	1	0	1
Estrogen receptor	0	4	1	5
Neuronal acetylcholine receptor subunit alpha-4	3	1	0	4
Adenosine receptor A3	0	4	0	4
Neuronal acetylcholine receptor subunit beta-2	3	1	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Cytochrome P450 2B6	0	1	1	2
UDP-glucuronosyltransferase 1A1	0	2	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
Sulfotransferase 1A1	0	2	1	4
Sodium-dependent dopamine transporter	0	6	0	6
Aldehyde oxidase	0	2	0	2
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Estrogen receptor beta	0	3	1	4
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	2	0	5
bcl-2-like protein 11 isoform 1	0	0	1	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chymotrypsinogen A	0	3	0	3
Steroid 17-alpha-hydroxylase/17,20 lyase	0	3	0	3
ATP-dependent translocase ABCB1	0	3	0	3
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Malate dehydrogenase, cytoplasmic	0	2	0	2
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	5	2	7
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	1	1
heat shock protein 90, putative	0	0	0	3
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
glp-1 receptor, partial	5	0	0	5
alpha-galactosidase	2	0	0	2
Thymidylate synthase	0	5	0	5
Thymidylate synthase	0	3	0	4
Dihydrofolate reductase	0	6	4	11
Aldo-keto reductase family 1 member B1	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	2	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	4	0	4
30S ribosomal protein S7	0	4	0	4
50S ribosomal protein L15	0	4	0	4
50S ribosomal protein L10	0	4	0	4
50S ribosomal protein L11	0	4	0	4
50S ribosomal protein L7/L12	0	4	0	4
50S ribosomal protein L19	0	4	0	4
50S ribosomal protein L1	0	4	0	4
50S ribosomal protein L20	0	4	0	4
50S ribosomal protein L27	0	4	0	4
50S ribosomal protein L28	0	4	0	4
50S ribosomal protein L29	0	4	0	4
50S ribosomal protein L31	0	4	0	4
50S ribosomal protein L31 type B	0	4	0	4
50S ribosomal protein L32	0	4	0	4
50S ribosomal protein L33	0	4	0	4
50S ribosomal protein L34	0	4	0	4
50S ribosomal protein L35	0	4	0	4
50S ribosomal protein L36	0	4	0	4
30S ribosomal protein S10	0	4	0	4
30S ribosomal protein S11	0	4	0	4
30S ribosomal protein S12	0	4	0	4
30S ribosomal protein S13	0	4	0	4
30S ribosomal protein S16	0	4	0	4
30S ribosomal protein S18	0	4	0	4
30S ribosomal protein S19	0	4	0	4
30S ribosomal protein S20	0	4	0	4
30S ribosomal protein S2	0	4	0	4
30S ribosomal protein S3	0	4	0	4
30S ribosomal protein S4	0	4	0	4
30S ribosomal protein S5	0	4	0	4
30S ribosomal protein S8	0	4	0	4
30S ribosomal protein S9	0	4	0	4
50S ribosomal protein L13	0	4	0	4
50S ribosomal protein L14	0	4	0	4
50S ribosomal protein L16	0	4	0	4
50S ribosomal protein L23	0	4	0	4
30S ribosomal protein S15	0	4	0	4
50S ribosomal protein L17	0	4	0	4
50S ribosomal protein L21	0	4	0	4
50S ribosomal protein L30	0	4	0	4
50S ribosomal protein L6	0	4	0	4
30S ribosomal protein S14	0	4	0	4
30S ribosomal protein S17	0	4	0	4
30S ribosomal protein S1	0	4	0	4
50S ribosomal protein L18	0	4	0	4
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	4	0	4
50S ribosomal protein L3	0	4	0	4
50S ribosomal protein L24	0	4	0	4
50S ribosomal protein L4	0	4	0	4
50S ribosomal protein L22	0	4	0	4
50S ribosomal protein L5	0	4	0	4
30S ribosomal protein S21	0	4	0	4
50S ribosomal protein L25	0	4	0	4
50S ribosomal protein L36 2	0	4	0	4
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
Histamine H2 receptor	0	6	0	6
Alpha-1D adrenergic receptor	0	4	0	4
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Toll-like receptor 7	0	0	1	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	4	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	2	0	2
Albumin	0	2	2	4
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	1	0	2
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	0	0	2
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 8	0	2	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	1	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
citrate synthase 2, partial	0	0	1	1
PAX8	0	0	0	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
nonstructural protein 1	2	0	0	2
LAP4	0	0	1	1
MEP2	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Mitogen-activated protein kinase 3	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
histone acetyltransferase KAT2A isoform 1	9	0	0	9
N-glycosylase/DNA lyase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	5
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
Estrogen receptor beta	0	1	0	2
Solute carrier family 22 member 1	0	4	0	4
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	2
Substance-K receptor	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Type-1 angiotensin II receptor	0	1	0	1
Delta-type opioid receptor	0	2	1	3
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	2
Phospholipase A-2-activating protein	0	2	0	2
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Alpha-mannosidase 2C1	0	2	0	2
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	6	0	7
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Carbonic anhydrase 2	0	3	1	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	5	0	5
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Pteridine reductase 1	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	3	0	3
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	3	0	4
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	2
Apoptotic peptidase activating factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
caspase-9 isoform alpha precursor	0	1	0	1
enteropeptidase precursor	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
caspase-3 isoform a preproprotein	0	1	0	1
bcl-2-related protein A1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Platelet-activating factor receptor	0	1	0	1
M-phase inducer phosphatase 1	0	2	0	2
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Trypanothione reductase	0	4	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Protein arginine N-methyltransferase 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Protein tyrosine phosphatase type IVA 3	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Protein S100-B	0	1	1	2
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
Protein S100-B	0	0	1	1
Trypsin-1	0	1	0	1
Acrosin	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Amiloride-sensitive amine oxidase [copper-containing]	0	1	0	1
Diamine acetyltransferase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	2	0	2
D(3) dopamine receptor	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Protein tyrosine phosphatase type IVA 2	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Protein tyrosine phosphatase type IVA 1	0	1	0	1
Protein arginine N-methyltransferase 1	0	2	0	2
Suppressor of tumorigenicity 14 protein	0	1	0	1
NFKB1 protein, partial	4	0	0	4
arylsulfatase A	6	0	0	6
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Tumor necrosis factor	0	1	0	1
Adenosine receptor A2b	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Chitotriosidase-1	0	2	1	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Endochitinase B1	0	2	1	3
serine-protein kinase ATM isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
dual specificity mitogen-activated protein kinase kinase 1	1	0	0	1
RAF proto-oncogene serine/threonine-protein kinase isoform b	1	0	0	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Cytochrome P450 1A1	0	2	0	2
Dihydrolipoyl dehydrogenase, mitochondrial	0	0	0	1
DNA topoisomerase 1	0	0	0	1
Type-1A angiotensin II receptor	1	0	0	1
Type-1B angiotensin II receptor	1	0	0	1
M-phase inducer phosphatase 2	0	1	0	1
Type-2 angiotensin II receptor	1	0	0	1
Platelet-activating factor acetylhydrolase	0	0	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Mitogen-activated protein kinase kinase kinase 14	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	3	0	3
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Trace amine-associated receptor 5	0	0	3	3
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Dipeptidyl peptidase 4	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
N	0	1	0	1
NPYLR7B	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Major prion protein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Carbonic anhydrase 1	0	3	0	3
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Tyrosinase	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
ATP-dependent 6-phosphofructokinase	0	2	0	2
Dihydropteroate synthase	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Protease	0	1	1	2
Ectonucleoside triphosphate diphosphohydrolase 2	0	1	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Cathepsin B	0	1	0	1
Protein kinase C alpha type	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Protein kinase C eta type	0	1	0	1
P2Y purinoceptor 2	0	1	1	2
Protein kinase C iota type	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 2	0	1	1	2
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2Y purinoceptor 4	0	0	1	1
NAD-dependent protein deacetylase HST2	0	1	0	1
P2X purinoceptor 3	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
DNA primase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
P2Y purinoceptor 6	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Dual specificity protein phosphatase 5	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 8	0	1	0	1
RmtA	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 3	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
P2Y purinoceptor 11	0	1	1	2
P2X purinoceptor 7	0	0	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Chain A, Alpha-mannosidase Ii	0	1	0	1
Chain A, ALPHA-MANNOSIDASE II	0	1	0	1
Chain A, Alpha-mannosidase Ii	0	1	0	1
Lysosomal alpha-mannosidase	0	1	0	1
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA	0	2	0	2
Alpha-mannosidase 2	0	1	0	1
Alpha-1,2-mannosidase family protein	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Glycoside hydrolase family 92	0	1	0	1
Glycoside hydrolase family 92	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase family protein	0	1	0	1
alpha-1,2-Mannosidase	0	1	0	1
Chain A, Prostatic Acid Phosphatase	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Acrosin	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Leishmaniasis, Mucocutaneous

Synonyms(1)

Research Excerpts

Overview

Actions

Treatment

Research

Studies (320)

Protein Targets (1,055)

Leishmaniasis, Mucocutaneous

Synonyms(1)

Research Excerpts

Overview

Actions

Treatment

Research

Studies (320)

Drugs Studied (131)

Protein Targets (1,055)