metronidazole has been researched along with Telangiectasis in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Telangiectasis: Permanent dilation of preexisting blood vessels (CAPILLARIES; ARTERIOLES; VENULES) creating small focal red lesions, most commonly in the skin or mucous membranes. It is characterized by the prominence of skin blood vessels, such as vascular spiders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to prepare a topical water-in-oil type microemulsion containing metronidazole and to compare its effectiveness with a commercial gel product in the treatment of rosacea." | 9.16 | Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea. ( Adişen, E; Çelebi, N; Erel, A; Kayiş, A; Tirnaksiz, F, 2012) |
| "A phase 4, open-label, multicenter, community-based study was conducted in subjects with mild to moderately severe papulopustular rosacea of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of metronidazole topical gel 0." | 9.12 | The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea. ( Del Rosso, JQ; Wolf, JE, 2007) |
| "75% metronidazole gel in improving principal signs of rosacea (inflammatory lesions and erythema)." | 9.10 | A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. ( Elewski, BE; Fleischer, AB; Pariser, DM, 2003) |
| "Eighty-one patients with rosacea were treated with either I% metronidazole cream or the cream base as a placebo for two months." | 9.05 | Treatment of rosacea with i% metronidazole cream. A double-blind study. ( Nielsen, PG, 1983) |
| "The aim of this study was to prepare a topical water-in-oil type microemulsion containing metronidazole and to compare its effectiveness with a commercial gel product in the treatment of rosacea." | 5.16 | Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea. ( Adişen, E; Çelebi, N; Erel, A; Kayiş, A; Tirnaksiz, F, 2012) |
| "A phase 4, open-label, multicenter, community-based study was conducted in subjects with mild to moderately severe papulopustular rosacea of various etiologies and locations to identify subgroups particularly responsive to twice-daily application of metronidazole topical gel 0." | 5.12 | The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea. ( Del Rosso, JQ; Wolf, JE, 2007) |
| "75% metronidazole gel in improving principal signs of rosacea (inflammatory lesions and erythema)." | 5.10 | A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial. ( Elewski, BE; Fleischer, AB; Pariser, DM, 2003) |
| "Eighty-one patients with rosacea were treated with either I% metronidazole cream or the cream base as a placebo for two months." | 5.05 | Treatment of rosacea with i% metronidazole cream. A double-blind study. ( Nielsen, PG, 1983) |
| "Acne vulgaris is a pervasive inflammatory disorder of the skin, with multiple etiologies and treatment options." | 1.40 | Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. ( Keck, L; Shariff, A; Zlotoff, B, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Del Rosso, JQ | 2 |
| Gallo, RL | 1 |
| Tanghetti, E | 1 |
| Webster, G | 1 |
| Thiboutot, D | 1 |
| Shariff, A | 1 |
| Keck, L | 1 |
| Zlotoff, B | 1 |
| Tirnaksiz, F | 1 |
| Kayiş, A | 1 |
| Çelebi, N | 1 |
| Adişen, E | 1 |
| Erel, A | 1 |
| Elewski, BE | 1 |
| Fleischer, AB | 1 |
| Pariser, DM | 1 |
| Wolf, JE | 1 |
| Chamaillard, M | 1 |
| Mortemousque, B | 1 |
| Boralevi, F | 1 |
| Marques da Costa, C | 1 |
| Aitali, F | 1 |
| Taïeb, A | 1 |
| Léauté-Labrèze, C | 1 |
| Nielsen, PG | 1 |
1 review available for metronidazole and Telangiectasis
| Article | Year |
|---|---|
An evaluation of potential correlations between pathophysiologic mechanisms, clinical manifestations, and management of rosacea.
Topics: Dermatologic Agents; Dicarboxylic Acids; Doxycycline; Humans; Immunity, Innate; Inflammation; Low-Le | 2013 |
4 trials available for metronidazole and Telangiectasis
| Article | Year |
|---|---|
Preparation and evaluation of topical microemulsion system containing metronidazole for remission in rosacea.
Topics: Administration, Topical; Adult; Double-Blind Method; Emulsions; Erythema; Female; Humans; Male; Metr | 2012 |
A comparison of 15% azelaic acid gel and 0.75% metronidazole gel in the topical treatment of papulopustular rosacea: results of a randomized trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Dermatologic Agents; Dicarboxylic Acids; Do | 2003 |
The CLEAR trial: results of a large community-based study of metronidazole gel in rosacea.
Topics: Administration, Cutaneous; Adult; Anti-Infective Agents; Erythema; Female; Follow-Up Studies; Gels; | 2007 |
Treatment of rosacea with i% metronidazole cream. A double-blind study.
Topics: Administration, Topical; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Erythema; Femal | 1983 |
2 other studies available for metronidazole and Telangiectasis
| Article | Year |
|---|---|
Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy.
Topics: Acne Vulgaris; Administration, Cutaneous; Adult; Androstenes; Anti-Infective Agents, Local; Combined | 2014 |
Cutaneous and ocular signs of childhood rosacea.
Topics: Adolescent; Blepharitis; Chalazion; Child; Child, Preschool; Conjunctivitis; Corneal Ulcer; Eye Dise | 2008 |