Severe Acute Malnutrition

Acute form of MALNUTRITION which usually affects children, characterized by a very low weight for height (below -3z scores of the median World Health Organization standards), visible severe wasting, or occurrence of nutritional EDEMA. It can be a direct or indirect cause of fatality in children suffering from DIARRHEA and PNEUMONIA. Do not confuse with starvation, a condition in which the body is not getting enough food, usually for extended periods of time.

Synonym
Severe Acute Malnutrition

Excerpt	Reference
"Their impact in severe acute malnutrition is not clearly established."	( Ahmad, F; Aktar, A; Alam, MT; Amin, SE; Chowdhury, B; Hossain, MA; Islam, MN; Kabir, MA; Pandit, P; Tusnim, I, 2022)
"Children with severe acute malnutrition are treated with antibiotics as outpatients."	( Berthé, F; Dantas, G; Grais, RF; Isanaka, S; Langdon, A; Langendorf, C; Schwartz, DJ; Sun, X; Trehan, I, 2023)

Excerpt	Reference
"Children treated for severe acute malnutrition (SAM) are at risk of refeeding hypophosphatemia."	( Babirekere-Iriso, E; Briend, A; Fabiansen, C; Friis, H; Girma, T; Hother, AL; Kæstel, P; Michaelsen, KF; Namusoke, H; Ritz, C; Rytter, MJ, 2016)
"Children who receive in-hospital treatment of severe acute malnutrition often have high mortality rates, and the reasons are not well understood."	( Babirekere-Iriso, E; Christensen, VB; Friis, H; Michaelsen, KF; Mortensen, CG; Mupere, E; Namusoke, H; Ritz, C; Rytter, MJ, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	53 (53.54)	28.8240
2020's	46 (46.46)	9.53

Drug	Relationship Strength	Studies	Trials
betaine	low	1	0
carnitine	medium	1	1
lactic acid	low	1	0
thiamine	low	1	0
gentamicin	low	1	0
hydroxyurea	medium	1	1
metronidazole	low	1	0
safrole	low	1	0
lysine	low	1	0
lactose	medium	1	1
methionine	low	2	0
sulfoxide	low	1	0
citrulline	medium	1	1
manganese	low	1	0
molybdenum	low	1	0
deuterium	low	2	0
amoxicillin	medium	19	6
zidovudine	medium	1	1
lamivudine	medium	1	1
lopinavir	medium	1	1
cobalt	low	1	0
7 alpha-hydroxy-4-cholesten-3-one	low	1	0
trimethoprim, sulfamethoxazole drug combination	medium	2	1
ritonavir	medium	1	1
glucosamine	medium	1	1
arachidonic acid	medium	1	1
retinol	medium	5	1
zithromax	medium	4	4
linoleic acid	medium	3	2
pulmicort	medium	1	1
cysteine	low	1	0
phosphorus	low	2	0
selenium	low	1	0
lumefantrine	low	1	0
cgp-56697	medium	4	1
amoxicillin-potassium clavulanate combination	low	1	0
mocetinostat	medium	1	1
methionine sulfoxide	low	1	0
lactulose	medium	1	1
acid phosphatase	low	1	0
alx-0600	medium	1	1
mannans	medium	1	1
natriuretic peptide, brain	low	1	0
glucagon-like peptide 2	low	1	0
vitamin b 12	medium	3	1
inosine	low	1	0
folic acid	low	2	0
neopterin	medium	1	1
trypsinogen	low	1	0

Protein Targets (517)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
AR protein	12	0	0	12
apical membrane antigen 1, AMA1	1	0	0	1
estrogen nuclear receptor alpha	14	0	0	14
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
DNA polymerase kappa isoform 1	4	0	0	4
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	10
Bile salt export pump	0	2	0	2
Bile salt export pump	0	12	0	12
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	2	0	2
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	9	0	9
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	3	0	0	3
15-lipoxygenase, partial	3	0	0	3
phosphopantetheinyl transferase	4	0	0	4
USP1 protein, partial	5	0	0	5
TDP1 protein	8	0	0	8
Microtubule-associated protein tau	5	0	0	5
thioredoxin glutathione reductase	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
vitamin D3 receptor isoform VDRA	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
nuclear receptor ROR-gamma isoform 1	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
cytochrome P450 3A4 isoform 1	7	0	0	7
histone acetyltransferase KAT2A isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	6	0	0	6
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	7	0	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Trypsin	0	2	0	2
Coagulation factor VII	0	2	0	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Aromatase	0	2	0	2
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit delta	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	7	0	0	7
Prostaglandin G/H synthase 2	0	0	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Histamine H2 receptor	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Calmodulin	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-2	7	0	0	7
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Fatty acid-binding protein 5	0	2	0	2
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
GABA theta subunit	7	0	0	7
Gamma-aminobutyric acid receptor subunit epsilon	7	0	0	7
Solute carrier organic anion transporter family member 1B3	0	4	0	4
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	4
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
GLI family zinc finger 3	12	0	0	12
Proton-coupled amino acid transporter 1	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, Ferritin light chain	3	0	0	3
acid sphingomyelinase	1	0	0	1
glp-1 receptor, partial	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	11	0	0	11
glucocerebrosidase	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
alpha-galactosidase	2	0	0	2
activating transcription factor 6	4	0	0	4
lysosomal alpha-glucosidase preproprotein	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
DNA polymerase beta	1	0	0	1
Cellular tumor antigen p53	8	0	0	8
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	1	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
acetylcholinesterase	5	0	0	5
thioredoxin reductase	2	0	0	2
Fumarate hydratase	3	0	0	3
NFKB1 protein, partial	2	0	0	2
GLS protein	3	0	0	3
EWS/FLI fusion protein	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
pregnane X nuclear receptor	11	0	0	11
polyprotein	3	0	0	3
Histone H2A.x	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Carbonic anhydrase 2	0	2	0	3
Stromelysin-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Smad3	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
IDH1	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
geminin	9	0	0	9
survival motor neuron protein isoform d	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Purine nucleoside phosphorylase	0	0	0	1
Adenosylhomocysteinase	0	1	0	2
Adenosine deaminase	0	1	0	1
RAR-related orphan receptor gamma	6	0	0	6
estrogen receptor 2 (ER beta)	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
cytochrome P450 2D6	6	0	0	6
thyroid stimulating hormone receptor	4	0	0	4
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Hsf1 protein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Albumin	0	0	2	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Capsid protein	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Reverse transcriptase/RNaseH	0	1	3	7
Luciferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
caspase 7, apoptosis-related cysteine protease	4	0	0	4
progesterone receptor	5	0	0	5
glucocorticoid receptor [Homo sapiens]	8	0	0	8
farnesoid X nuclear receptor	5	0	0	5
peroxisome proliferator-activated receptor delta	7	0	0	7
peroxisome proliferator activated receptor gamma	6	0	0	6
caspase-3	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
thyroid hormone receptor beta isoform 2	10	0	0	10
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
Free fatty acid receptor 1	0	0	1	1
Sterol O-acyltransferase 1	0	1	0	1
Fatty acid-binding protein, heart	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Dual specificity protein phosphatase 3	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Free fatty acid receptor 4	0	0	1	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
G	5	0	0	5
67.9K protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
peripheral myelin protein 22	4	0	0	4
Transmembrane protease serine 2	0	0	1	1
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Procathepsin L	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	5	0	6
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	3	1	4
Gag-Pol polyprotein	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Glutamate receptor 2	3	0	0	3
Alpha-1D adrenergic receptor	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Spike glycoprotein	2	0	1	3
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Protease	0	4	3	9
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	2	0	2
Inositol hexakisphosphate kinase 1	5	0	0	5
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Angiotensin-converting enzyme 2	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Protease	0	4	3	7
cytochrome P450 2C9, partial	5	0	0	5
aryl hydrocarbon receptor	4	0	0	4
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Thioredoxin reductase	0	1	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
mitogen-activated protein kinase 1	3	0	0	3
Flavodoxin	0	0	0	1
TAR DNA-binding protein 43	2	0	0	2
PPM1D protein	2	0	0	2
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	2	0	2
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Thrombopoietin	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
Estrogen receptor	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Progesterone receptor	0	1	0	1
Glucocorticoid receptor	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Mineralocorticoid receptor	0	1	1	2
Matrix metalloproteinase-9	0	1	0	1
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Interleukin-5 receptor subunit alpha	0	1	0	1
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Estrogen receptor beta	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
interleukin 8	2	0	0	2
pregnane X receptor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
neuropeptide S receptor isoform A	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier family 22 member 3	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Substance-K receptor	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Vasopressin V1a receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Thromboxane-A synthase	0	0	0	1
Sodium/bile acid cotransporter	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Solute carrier family 22 member 6	0	0	0	1
Thymidine kinase, cytosolic	0	2	0	3
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
chromobox protein homolog 1	1	0	0	1
streptokinase A precursor	0	0	1	1
twin arginine protein translocation system - TatA protein	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (99)

Protein Targets (517)

Severe Acute Malnutrition

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (99)

Drugs Studied (65)

Protein Targets (517)