metronidazole has been researched along with Anastomotic Leak in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Anastomotic Leak: Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.
Excerpt | Relevance | Reference |
---|---|---|
"Three hundred ten patients with colon cancer randomly were assigned to one of three groups." | 2.79 | Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: prospective randomized trial. ( Kamata, H; Koga, Y; Okada, K; Ozaki, T; Sadahiro, S; Suzuki, T; Tanaka, A, 2014) |
"Among these, a minimal anastomotic leakage may lead to gas spreading into surrounding soft tissues." | 1.43 | Pneumoretroperitoneum and pneumomediastinum after Stapled Anopexy Is conservative treatment possible? ( Frassani, S; Gabrielli, F; Guttadauro, A; Macchini, D; Maternini, M, 2016) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 5 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Vo, E | 1 |
Massarweh, NN | 1 |
Chai, CY | 1 |
Tran Cao, HS | 1 |
Zamani, N | 1 |
Abraham, S | 1 |
Adigun, K | 1 |
Awad, SS | 1 |
Sadahiro, S | 1 |
Suzuki, T | 1 |
Tanaka, A | 1 |
Okada, K | 1 |
Kamata, H | 1 |
Ozaki, T | 1 |
Koga, Y | 1 |
Ozdemir, S | 1 |
Gulpinar, K | 1 |
Ozis, SE | 1 |
Sahli, Z | 1 |
Kesikli, SA | 1 |
Korkmaz, A | 1 |
Gecim, IE | 1 |
Ikeda, A | 1 |
Konishi, T | 1 |
Ueno, M | 1 |
Fukunaga, Y | 1 |
Nagayama, S | 1 |
Fujimoto, Y | 1 |
Akiyoshi, T | 1 |
Yamaguchi, T | 1 |
Macchini, D | 1 |
Guttadauro, A | 1 |
Frassani, S | 1 |
Maternini, M | 1 |
Gabrielli, F | 1 |
2 trials available for metronidazole and Anastomotic Leak
Article | Year |
---|---|
Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: prospective randomized trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Anti-Bacterial Agents; Catha | 2014 |
Randomized clinical trial of oral and intravenous versus intravenous antibiotic prophylaxis for laparoscopic colorectal resection.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Anti-Bacterial Agents; Antib | 2016 |
3 other studies available for metronidazole and Anastomotic Leak
Article | Year |
---|---|
Association of the Addition of Oral Antibiotics to Mechanical Bowel Preparation for Left Colon and Rectal Cancer Resections With Reduction of Surgical Site Infections.
Topics: Administration, Oral; Aged; Anastomotic Leak; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cathart | 2018 |
The effects of preoperative oral antibiotic use on the development of surgical site infection after elective colorectal resections: A retrospective cohort analysis in consecutively operated 90 patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Anti-Bacterial Agents; Antib | 2016 |
Pneumoretroperitoneum and pneumomediastinum after Stapled Anopexy Is conservative treatment possible?
Topics: Anastomotic Leak; Anti-Bacterial Agents; Combined Modality Therapy; Conservative Treatment; Hemorrho | 2016 |