metronidazole has been researched along with Gingival Overgrowth in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gingival Overgrowth: Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of metronidazole on cyclosporine-induced gingival overgrowth (GO), a prospective intra-subject double-blind longitudinal study was performed on six heart transplant patients with GO." | 9.10 | Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients. ( Montebugnoli, L; Prati, C; Servidio, D, 2002) |
| "To evaluate the efficacy of metronidazole on cyclosporine-induced gingival overgrowth (GO), a prospective intra-subject double-blind longitudinal study was performed on six heart transplant patients with GO." | 5.10 | Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients. ( Montebugnoli, L; Prati, C; Servidio, D, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mesa, FL | 1 |
| Osuna, A | 1 |
| Aneiros, J | 1 |
| Gonzalez-Jaranay, M | 1 |
| Bravo, J | 1 |
| Junco, P | 1 |
| Del Moral, RG | 1 |
| O'Valle, F | 1 |
| Chand, DH | 1 |
| Quattrocchi, J | 1 |
| Poe, SA | 1 |
| Terezhalmy, GT | 1 |
| Strife, CF | 1 |
| Cunningham, RJ | 1 |
| Verma, A | 1 |
| Dhawan, A | 1 |
| Montebugnoli, L | 1 |
| Servidio, D | 1 |
| Prati, C | 1 |
3 trials available for metronidazole and Gingival Overgrowth
| Article | Year |
|---|---|
Antibiotic treatment of incipient drug-induced gingival overgrowth in adult renal transplant patients.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cyclosporin | 2003 |
Trial of metronidazole vs. azithromycin for treatment of cyclosporine-induced gingival overgrowth.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; | 2004 |
Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients.
Topics: Analysis of Variance; Anti-Infective Agents; Chi-Square Distribution; Cyclosporine; Dental Plaque In | 2002 |
1 other study available for metronidazole and Gingival Overgrowth
| Article | Year |
|---|---|
Re: Trial of metronidazole vs. azithromycin for treatment of cyclosporine-induced gingival overgrowth.
Topics: Anti-Bacterial Agents; Azithromycin; Cyclosporine; Gingival Overgrowth; Humans; Immunosuppressive Ag | 2005 |