metronidazole has been researched along with Envenomation, Snakebite in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kularatne, SA | 1 |
| Kumarasiri, PV | 1 |
| Pushpakumara, SK | 1 |
| Dissanayaka, WP | 1 |
| Ariyasena, H | 1 |
| Gawarammana, IB | 1 |
| Senanayake, N | 1 |
| Russell, FE | 1 |
| Vaughan-Scott, T | 1 |
| Lobetti, RG | 1 |
| Taylor, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Routine vs. Clinically-Directed Antibiotic Treatment in Snake Bite With Local Envenomation: a Randomised Controlled Trial[NCT02570347] | Phase 4 | 130 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for metronidazole and Envenomation, Snakebite
| Article | Year |
|---|---|
Routine antibiotic therapy in the management of the local inflammatory swelling in venomous snakebites: results of a placebo-controlled study.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Edema; Female; Humans; Inflammation; Lower Ex | 2005 |
Pharmacodynamic observations on metronidazole therapy. Side effects in endocrine, metabolic and auto-immune disorders. 3. Anti-ischemic and anti-inflammatory action in peripheral vascular disorders.
Topics: Blood Circulation; Blood Flow Velocity; Blood Pressure; Clinical Trials as Topic; Diabetes Complicat | 1966 |
2 other studies available for metronidazole and Envenomation, Snakebite
| Article | Year |
|---|---|
Metronidazole in snake venom poisoning.
Topics: Adult; Child; Humans; Male; Metronidazole; Snake Bites | 1966 |
Boomslang envenomation in a dog.
Topics: Amoxicillin; Animals; Antivenins; Dog Diseases; Dogs; Hemorrhage; Male; Metronidazole; Penicillins; | 1995 |