metronidazole has been researched along with Kaposi Disease in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the first case available in the literature of hepatotoxicity associated with metronidazole treatment in a xeroderma pigmentosum patient." | 8.12 | Metronidazole-induced hepatotoxicity in a patient with xeroderma pigmentosum: A case report. ( Grassi, G; Invernizzi, C; Nava, M; Panizzuti, F; Vanoli, J, 2022) |
| "We describe the first case available in the literature of hepatotoxicity associated with metronidazole treatment in a xeroderma pigmentosum patient." | 4.12 | Metronidazole-induced hepatotoxicity in a patient with xeroderma pigmentosum: A case report. ( Grassi, G; Invernizzi, C; Nava, M; Panizzuti, F; Vanoli, J, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abiona, A | 1 |
| Cordeiro, N | 1 |
| Fawcett, H | 1 |
| Tamura, D | 1 |
| Khan, SG | 1 |
| DiGiovanna, JJ | 1 |
| Lehmann, AR | 1 |
| Fassihi, H | 1 |
| Vanoli, J | 1 |
| Nava, M | 1 |
| Invernizzi, C | 1 |
| Panizzuti, F | 1 |
| Grassi, G | 1 |
2 other studies available for metronidazole and Kaposi Disease
| Article | Year |
|---|---|
Metronidazole-Induced Hepatitis in a Teenager With Xeroderma Pigmentosum and Trichothiodystrophy Overlap.
Topics: Adolescent; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Female; Fibroblasts; Huma | 2021 |
Metronidazole-induced hepatotoxicity in a patient with xeroderma pigmentosum: A case report.
Topics: Adult; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; DNA Repair; Humans; Male; Metr | 2022 |