metronidazole has been researched along with Cronobacter Infections in 20 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was given to both groups as a 500 mg intravenous infusion tid." | 2.67 | A randomized multicentre trial of pefloxacin plus metronidazole and gentamicin plus metronidazole in the treatment of severe intra-abdominal infections. Report from a Swedish Study Group. ( , 1990) |
| "Metronidazole pretreatment increased susceptibility to C." | 1.37 | Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. ( Bergstrom, KS; Finlay, BB; Gill, N; Keeney, KM; Menendez, A; Russell, SL; Vallance, BA; Willing, B; Wlodarska, M, 2011) |
| "Antibiotics both prevent and treat the colitis through correction of this primary bacterial alteration." | 1.31 | Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. ( Doyle, JS; Fedorak, RN; Jewell, LD; Madsen, KL; Rennie, RP; Tavernini, MM, 2000) |
| "Bacterial meningitis is not considered a separate disease entity but a complication of bacteremia and sepsis." | 1.27 | [Chemotherapy of severe bacterial infections in pediatrics]. ( Guggenbichler, JP, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (35.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoffman, T | 1 |
| Lellouche, J | 1 |
| Nutman, A | 1 |
| Temkin, E | 1 |
| Frenk, S | 1 |
| Harbarth, S | 1 |
| Carevic, B | 1 |
| Cohen-Percia, S | 1 |
| Kariv, Y | 1 |
| Fallach, N | 1 |
| Klausner, J | 1 |
| Carmeli, Y | 1 |
| Smith, S | 1 |
| Bagshaw, RJ | 1 |
| Hanson, J | 1 |
| Falcone, M | 1 |
| Russo, A | 1 |
| Iraci, F | 1 |
| Carfagna, P | 1 |
| Goldoni, P | 1 |
| Vullo, V | 1 |
| Venditti, M | 1 |
| Tuduri, I | 1 |
| Amezyane, T | 1 |
| Abouzahir, A | 1 |
| El Kharrass, A | 1 |
| Bassou, D | 1 |
| Fatihi, J | 1 |
| Hammi, S | 1 |
| Mahassin, F | 1 |
| Ghafir, D | 1 |
| Ohayon, V | 1 |
| Wlodarska, M | 1 |
| Willing, B | 1 |
| Keeney, KM | 1 |
| Menendez, A | 1 |
| Bergstrom, KS | 1 |
| Gill, N | 1 |
| Russell, SL | 1 |
| Vallance, BA | 1 |
| Finlay, BB | 1 |
| Citron, DM | 1 |
| Tyrrell, KL | 1 |
| Merriam, CV | 1 |
| Goldstein, EJ | 1 |
| Leung, W | 1 |
| Malhi, G | 1 |
| Willey, BM | 1 |
| McGeer, AJ | 1 |
| Borgundvaag, B | 1 |
| Thanabalan, R | 1 |
| Gnanasuntharam, P | 1 |
| Le, B | 1 |
| Weizman, AV | 1 |
| Croitoru, K | 1 |
| Silverberg, MS | 1 |
| Steinhart, AH | 1 |
| Nguyen, GC | 1 |
| Scicluna, EA | 1 |
| Haider, J | 1 |
| Borg, MA | 1 |
| Cuschieri, P | 1 |
| Ea, HK | 1 |
| Zeller, V | 1 |
| Chicheportiche, V | 1 |
| Desplaces, N | 1 |
| Ziza, JM | 1 |
| Guggenbichler, JP | 1 |
| Baradnay, G | 1 |
| Nagy, A | 1 |
| Paerregaard, A | 1 |
| Justesen, T | 1 |
| Prytz, H | 1 |
| Andersen, B | 1 |
| Gudmand-Hoeyer, E | 1 |
| Madsen, KL | 1 |
| Doyle, JS | 1 |
| Tavernini, MM | 1 |
| Jewell, LD | 1 |
| Rennie, RP | 1 |
| Fedorak, RN | 1 |
| Ammori, BJ | 1 |
| Ingham, HR | 1 |
| Selkon, JB | 1 |
| Sisson, PR | 1 |
| Middleton, RL | 1 |
| Claesson, BE | 1 |
| Filipsson, S | 1 |
| Holmlund, DE | 1 |
| Mätzsch, TW | 1 |
| Wählby, L | 1 |
| Kradolfer, F | 1 |
| Jarumilinta, R | 1 |
| Sackmann, W | 1 |
| Gilman, RH | 1 |
| Madasamy, M | 1 |
| Gan, E | 1 |
| Mariappan, M | 1 |
| Davis, CE | 1 |
| Kyser, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment Of Changes In Gut Microbiota Of Patients With Recurrent Clostridioides Difficile Infection After Fecal Microbiota Transplantation: Prospective Study[NCT05739825] | 20 participants (Anticipated) | Observational | 2023-02-13 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for metronidazole and Cronobacter Infections
| Article | Year |
|---|---|
A randomized multicentre trial of pefloxacin plus metronidazole and gentamicin plus metronidazole in the treatment of severe intra-abdominal infections. Report from a Swedish Study Group.
Topics: Abdomen; Adolescent; Adult; Aged; Aged, 80 and over; Drug Therapy, Combination; Enterobacteriaceae I | 1990 |
Selective cefuroxime prophylaxis following colorectal surgery based on intra-operative dipslide culture.
Topics: Cefuroxime; Cephalosporins; Colon; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Metron | 1986 |
18 other studies available for metronidazole and Cronobacter Infections
| Article | Year |
|---|---|
The effect of prophylaxis with ertapenem versus cefuroxime/metronidazole on intestinal carriage of carbapenem-resistant or third-generation-cephalosporin-resistant Enterobacterales after colorectal surgery.
Topics: Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Cefuroxime; Cephalosporins; Colorectal Surgery; | 2021 |
The microbiology of crocodile attacks in Far North Queensland: implications for empirical antimicrobial therapy.
Topics: Adolescent; Adult; Aged; Alligators and Crocodiles; Animals; Anti-Bacterial Agents; Bacillus cereus; | 2017 |
Risk Factors and Outcomes for Bloodstream Infections Secondary to Clostridium difficile Infection.
Topics: Aged; Anti-Infective Agents; Bacteremia; Candida; Candidiasis; Case-Control Studies; Clostridioides | 2016 |
Considerations about the article by St. Peter "Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomised trial". J Pediatr Surg 2008;43:981-985.
Topics: Abdominal Abscess; Appendicitis; Cefoxitin; Ceftriaxone; Cefuroxime; Child; Community-Acquired Infec | 2008 |
[Septic pylephlebitis associated with Enterobacter cloacae septicemia].
Topics: Abdominal Pain; Adult; Anti-Bacterial Agents; Anticoagulants; Bacteremia; Ceftriaxone; Community-Acq | 2010 |
Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis.
Topics: Animals; Anti-Bacterial Agents; Cell Separation; Citrobacter rodentium; Colitis; Enterobacteriaceae | 2011 |
In vitro activities of CB-183,315, vancomycin, and metronidazole against 556 strains of Clostridium difficile, 445 other intestinal anaerobes, and 56 Enterobacteriaceae species.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Clostridioides difficile; Enterobacteriaceae; Enterobact | 2012 |
Prevalence and predictors of MRSA, ESBL, and VRE colonization in the ambulatory IBD population.
Topics: Adult; Aged; Ambulatory Care; Anti-Bacterial Agents; beta-Lactamases; Carrier State; Cephalosporins; | 2012 |
Prevalence of extended-spectrum beta-lactamase-producing enterobacteriaceae in Maltese hospitalized patients.
Topics: beta-Lactam Resistance; beta-Lactamases; Cross Infection; Cross-Sectional Studies; Enterobacteriacea | 2007 |
Polybacterial pyomyositis following laparoscopic colectomy for complicated diverticulosis.
Topics: Abdominal Abscess; Aged; Anti-Bacterial Agents; Ceftriaxone; Colectomy; Colon, Sigmoid; Diverticulit | 2007 |
[Chemotherapy of severe bacterial infections in pediatrics].
Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Cefotaxime; Cephalosporins; Clindamyci | 1983 |
Modern trends in colorectal surgery.
Topics: Anti-Bacterial Agents; Colectomy; Colonic Neoplasms; Enterobacteriaceae Infections; Female; Humans; | 1983 |
Metronidazole treatment of bypass-enteropathy after jejunoileal shunt-operation for obesity.
Topics: Adult; Bacteroides Infections; Enterobacteriaceae Infections; Female; Humans; Ileum; Jejunum; Male; | 1982 |
Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice.
Topics: Age Factors; Animals; Anti-Bacterial Agents; Bacteroides; Ciprofloxacin; Clostridium; Colitis; Enter | 2000 |
Laparoscopic transgastric pancreatic necrosectomy for infected pancreatic necrosis.
Topics: Aged; Amylases; Anti-Bacterial Agents; Blood Loss, Surgical; Ciprofloxacin; Debridement; Enterobacte | 2002 |
Metronidazole in large-bowel surgery.
Topics: Bacteroides fragilis; Bacteroides Infections; Enterobacteriaceae Infections; Humans; Intestine, Larg | 1979 |
The amoebicidal, trichomonicidal, and antibacterial effects of niridazole in laboratory animals.
Topics: Amebiasis; Amebicides; Amoeba; Animals; Anthelmintics; Antimony; Antiprotozoal Agents; Chloroquine; | 1969 |
Edwardsiella tarda in jungle diarrhoea and a possible association with Entamoeba histolytica.
Topics: Agglutination Tests; Child; Child, Preschool; Diarrhea; Entamoeba histolytica; Enterobacteriaceae; E | 1971 |