Fournier Disease

An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease.

Synonym
Fournier's Disease
Fournier Gangrene
Fournier Disease
Fournier's Gangrene

Excerpt	Reference
"This suggests that Fournier's gangrene is related to some form of localized vasculitis, and represents a local Shwartzman phenomenon."	( Diepgen, TL; Hornstein, OP; Schultz, ES; von den Driesch, P, 1995)
"Fournier's gangrene is described as a fulminant necrotizing fasciitis of the scrotum and penis."	( Aouad, K; Jaffarbey, J; Lévy, V; Zittoun, R, 1998)
"Fournier's disease is a potentially fatal acute, gangrenous infection of the scrotum, penis, or perineum associated with a synergistic bacterial infection of the subcutaneous fat and superficial fascia."	( Carrillo, EH; Olsofka, JN; Polk, HC; Spain, DA, 1999)
"Fournier's gangrene is a necrotizing fasciitis of the scrotum or perineum that may extend by way of the fascial planes to the penis and the anterior abdominal wall up to the clavicles, buttocks, or lower extremities."	( Jeong, HJ, 2004)
"Fournier gangrene is a life-threatening necrotizing fasciitis of the perineal-scrotal area that occurs in diabetic males."	( Marinella, MA, 2005)
"Fournier's gangrene is still a severe disease."	( As, A; Ayan, F; Cetinkale, O; Paksoy, SM; Polat, SS; Sakoglu, N; Sirin, F; Sunamak, O, 2005)
"Fournier gangrene is a necrotizing fasciitis of the perineal and genital region, which almost exclusively affects men."	( Aschoff, R; Baldauf, A; Leike, S; Meurer, M; Wirth, MP, 2006)
"Fournier's gangrene is an aggressive form of necrotizing fasciitis of the perineal, perianal or genital regions, usually caused by a polymicrobial infection that includes virulent organisms."	( Diab, AI; Safioleas, MC; Safioleas, PM; Stamatakos, MC, 2006)
"Fournier's gangrene is uncommon in pediatric age group, and little is known about the disease in the newborn period and infancy."	( Agir, H; Ekingen, G; Günlemez, A; Isken, T; Oncel, S, 2008)
"Fournier's Gangrene is a rare process having an unknown origin which affects soft tissue in the genital and perirectal area."	( Lorente Fernández, G; Rodríguez Cancio, MC; Verdú Moresco, A, 2008)
"Fournier's gangrene is a rare but life-threatening disease characterized by necrotizing fasciitis of the perineal area."	( Florez, ID; Garcés, C; Gómez, C; Muñoz, JD, 2010)
"Fournier's gangrene is an acute, rapidly progressive, and potentially fatal, infective necrotizing fasciitis affecting the external genitalia, perineal or perianal regions."	( Aslanidis, T; Giannakou-Peftoulidou, M; Myrou, A, 2014)
"Fournier's gangrene is not a common cause of morbidity in renal transplant recipients, but, if it occurs, it is difficult to treat because of the immunosuppression and associated increased mortality rate."	( Drakopoulos, S; Grigorakis, A; Koukoulaki, M; Papadimitriou, G; Vardas, K; Vougas, V, 2015)
"Fournier gangrene is a rare, rapidly progressive, life-threatening condition."	( Chojnicki, M; Haponiuk, I; Irga-Jaworska, N; Jaworski, R; Naumiuk, Ł, 2017)
"Fournier gangrene is a necrotizing fasciitis that affects the genital, perineal and perianal regions, of sudden onset and rapidly progressive dissemination."	( Fernández Berisso, S; Liern, M; Moreno, MS; Padilla, ME; Podestá, ML; Trinitario, LP; Vietri, AB, 2020)
"BACKGROUND Fournier's gangrene is an idiopathic form of necrotizing fasciitis involving the genital and perineal regions; it is associated with high complication and mortality rates."	( Felicia, FV; Hartoyo, E, 2022)

Excerpt	Reference
"We report a case of Fournier's gangrene, histologically characterized by a necrotizing vasculitis, in which surgical resection of the necrotic tissue and antibiotic treatment failed to halt progression of the disease, whereas complete remission was achieved by high-dose corticosteroid therapy."	( Diepgen, TL; Hornstein, OP; Schultz, ES; von den Driesch, P, 1995)
"Recently, we experienced a case of Fournier's gangrene associated with sparganosis in the scrotum, which was treated with antibiotics and extensive debridement including removal of a white, flat, shiny sparganum worm."	( Jeong, HJ, 2004)
"In our clinic, 25 patients with Fournier's gangrene were treated between 1995 and 2000."	( Arslan, M; Ayder, AR; Suelozgen, T; Yeniyol, CO, 2004)
"Most cases of Fournier gangrene are polymicrobic and require urgent surgical debridement and broad-spectrum antibiotic therapy."	( Marinella, MA, 2005)
"Forty-one patients with Fournier's gangrene were reviewed on the parameters of age, sex, aetiological agents, predisposing factors, treatment modalities and outcomes."	( As, A; Ayan, F; Cetinkale, O; Paksoy, SM; Polat, SS; Sakoglu, N; Sirin, F; Sunamak, O, 2005)
"Between 1995 and 2010, 40 patients with Fournier's gangrene were treated in our institution."	( Ben Jdidia, G; Gammoudi, A; Horchani, A; Maalla, R; Sallami, S; Tarhouni, L, 2012)
"Fifteen patients with Fournier's gangrene were treated in this study."	( Ceylan, E; Copçu, E; Irkören, S; Sivrioğlu, N; Sonel, AM, 2013)
"A few days later, he developed Fournier's gangrene and urgent radical surgical debridement of the scrotum was performed, along with aggressive antibiotic regimen and the immunosuppressive treatment was modified."	( Drakopoulos, S; Grigorakis, A; Koukoulaki, M; Papadimitriou, G; Vardas, K; Vougas, V, 2015)
"The patient was treated for Fournier's gangrene and diabetic ketoacidosis."	( Kasbawala, K; Majumdar, SK; Stamatiades, GA, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.23)	23.3326
1990's	8 (9.88)	12.5806
2000's	21 (25.93)	18.1394
2010's	38 (46.91)	28.8240
2020's	13 (16.05)	9.53

Drug	Relationship Strength	Studies
uric acid	low	1
urea	low	5
fluconazole	low	2
fluorouracil	low	3
gentamicin	low	2
glimepiride	low	1
ibuprofen	low	1
meperidine	low	1
metformin	low	2
metronidazole	low	4
pioglitazone	low	1
prednisolone	low	1
prednisone	low	1
biguanides	low	1
sucrose	low	1
methicillin	low	1
arginine	low	1
isoprene	low	1
methylprednisolone	low	1
penicillanic acid	low	2
sulfan blue	low	1
c.i. 42510	low	1
arsenic trioxide	low	1
vancomycin	low	1
streptomycin	low	1
vantocil	low	1
octyl 2-cyanoacrylate	low	1
gadolinium	low	1
camptothecin	low	1
cefazolin	low	1
amoxicillin	low	1
tobramycin	low	1
amikacin	low	1
piperacillin	low	2
glucose, (beta-d)-isomer	low	3
cephalosporin c	low	3
fluorodeoxyglucose f18	low	2
oxazolidin-2-one	low	1
fibrinogen	low	1
mci 9038	low	1
imipenem, anhydrous	low	2
tadalafil	low	1
tazobactam	low	2
povidone-iodine	low	3
linezolid	low	1
tretinoin	low	5
cocaine	low	2
clindamycin	low	5
l 743,872	low	2
dipyrone	low	3
zinc oxide	low	1
bilirubin	low	1
alprostadil	low	1
meprednisone	low	1
cefotaxime	low	3
ppi-0903	low	1
dapagliflozin	low	2
linagliptin	low	1
empagliflozin	low	1
ro13-9904	low	2
canagliflozin	low	2
levoleucovorin	low	3

Protein Targets (810)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
TDP1 protein	16	0	0	16
AR protein	19	0	0	19
glucocorticoid receptor [Homo sapiens]	15	0	0	15
estrogen nuclear receptor alpha	27	0	0	27
peroxisome proliferator activated receptor gamma	10	0	0	10
ATP-binding cassette sub-family C member 3	0	16	0	16
Multidrug resistance-associated protein 4	0	16	0	18
Bile salt export pump	0	21	0	21
Cellular tumor antigen p53	14	0	0	14
Thromboxane-A synthase	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	14	0	14
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
peripheral myelin protein 22	6	0	0	6
histone acetyltransferase KAT2A isoform 1	6	0	0	6
lamin isoform A-delta10	14	0	0	14
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Beta-lactamase	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	6
Beta-lactamase	0	0	0	4
Beta-lactamase	0	1	0	6
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
DNA polymerase kappa isoform 1	4	0	0	4
Bile salt export pump	0	4	0	4
Beta-lactamase SHV-1	0	1	0	4
Beta-lactamase SHV-1	0	2	0	7
Cytochrome P450 2C9	0	9	1	11
Beta-lactamase	0	1	0	6
Kappa-type opioid receptor	0	0	0	5
Solute carrier family 15 member 1	0	5	0	5
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	4
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	4
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	8	0	0	8
phosphopantetheinyl transferase	5	0	0	5
NFKB1 protein, partial	3	0	0	3
GLS protein	5	0	0	5
thyroid stimulating hormone receptor	6	0	0	6
alpha-galactosidase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	10	0	0	10
flap endonuclease 1	5	0	0	5
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	3	0	0	3
Cytochrome P450 3A4	0	3	1	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
thyroid hormone receptor beta isoform 2	10	0	0	10
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, Cruzipain	3	0	0	3
USP1 protein, partial	7	0	0	7
Microtubule-associated protein tau	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
vitamin D3 receptor isoform VDRA	8	0	0	8
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	3	0	4
GLI family zinc finger 3	15	0	0	15
progesterone receptor	7	0	0	7
retinoid X nuclear receptor alpha	9	0	0	9
estrogen-related nuclear receptor alpha	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Glutamate receptor 2	8	0	0	8
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	7	0	0	7
Chain A, Ferritin light chain	4	0	0	4
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	2	0	0	2
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	2	0	0	2
PPM1D protein	3	0	0	3
Thrombopoietin	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
regulator of G-protein signaling 4	4	0	0	4
EWS/FLI fusion protein	9	0	0	9
polyprotein	2	0	0	2
67.9K protein	3	0	0	3
glucocerebrosidase	2	0	0	2
putative alpha-glucosidase	1	0	0	1
Bloom syndrome protein isoform 1	4	0	0	4
lysosomal alpha-glucosidase preproprotein	1	0	0	1
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
huntingtin isoform 2	3	0	0	3
ras-related protein Rab-9A	1	0	0	1
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	6	0	0	6
geminin	15	0	0	15
survival motor neuron protein isoform d	5	0	0	5
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	5	1	0	6
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Histone deacetylase 3	0	2	0	2
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	2	1	4
DNA ligase	0	1	0	1
Interferon beta	13	0	0	13
Integrin beta-3	4	0	0	4
Integrin alpha-IIb	4	0	0	4
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	1	1	6
DNA topoisomerase 2-alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit delta	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	5	1	0	6
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	5	1	0	6
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Type-2 restriction enzyme HindIII	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Histone deacetylase 4	0	2	0	2
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit beta-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit beta-2	5	1	0	6
DNA topoisomerase 2-beta	0	0	0	1
DNA topoisomerase 1	0	1	0	2
Histone deacetylase 1	0	2	0	2
DNA topoisomerase 1	0	1	0	1
Integrase	0	2	0	2
Histone deacetylase 7	0	2	0	2
GABA theta subunit	5	1	0	6
Histone deacetylase 2	0	2	0	2
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	5	1	0	6
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Sodium/glucose cotransporter 1	0	2	3	5
Sodium/glucose cotransporter 2	0	3	3	6
Spike glycoprotein	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Luciferase	7	0	0	7
RAR-related orphan receptor gamma	9	0	0	9
Smad3	3	0	0	3
cytochrome P450 2D6	6	0	0	6
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 6	0	3	0	4
Solute carrier family 22 member 8	0	5	0	5
Solute carrier family 22 member 11	0	2	0	2
Solute carrier family 22 member 8	0	2	0	2
Beta-lactamase	0	3	0	5
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	4
Beta-lactamase	0	1	0	5
Metallo-beta-lactamase type 2	0	0	0	4
Metallo-beta-lactamase VIM-11	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	3
Metallo-beta-lactamase VIM-19	0	0	0	4
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	1	0	4
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	2	0	5
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	2	0	4
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-13	0	0	0	4
Beta-lactamase	0	1	0	4
Metallo-beta-lactamase VIM-2	0	0	0	4
Metallo-beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-b-lactamase	0	0	0	5
BlaVIM-1	0	0	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	4
Beta-lactamase class B VIM-2	0	0	0	5
Beta-lactamase VIM-1	0	0	0	4
Beta-lactamase	0	2	0	3
Albumin	0	1	3	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	4
Beta-lactamase Toho-1	0	0	0	1
Solute carrier family 22 member 7	0	1	0	1
Beta-lactamase	0	1	0	4
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	5
Histamine H3 receptor	0	0	0	3
Solute carrier family 22 member 7	0	1	0	1
Protein-arginine deiminase type-4	0	3	0	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Amyloid-beta precursor protein	1	3	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	4	0	4
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	0	0	2
Sodium-dependent noradrenaline transporter	0	2	1	3
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	4	0	5
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	3	0	3
Cholinesterase	0	2	1	3
Sodium/glucose cotransporter 2	0	0	1	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Solute carrier family 5 member 4	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
farnesoid X nuclear receptor	5	0	0	5
G	11	0	0	11
peroxisome proliferator-activated receptor delta	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	7	0	0	7
cytochrome P450 2C9 precursor	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
heat shock protein beta-1	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
NAD	0	1	0	1
Urease	0	1	0	1
NAD	0	1	0	2
Mitogen-activated protein kinase 1	0	2	0	2
Histamine H2 receptor	4	0	0	4
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Inositol hexakisphosphate kinase 1	11	0	0	11
G-protein coupled receptor 35	0	1	1	2
cytochrome P450 2C9, partial	11	0	0	11
acetylcholinesterase	8	0	0	8
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
pregnane X nuclear receptor	15	0	0	15
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Lanosterol 14-alpha demethylase	0	2	1	3
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	1	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
interleukin 8	2	0	0	2
endonuclease IV	2	0	0	2
glp-1 receptor, partial	3	0	0	3
Skn7p	0	0	0	1
pregnane X receptor	3	0	0	3
nonstructural protein 1	4	0	0	4
arylsulfatase A	4	0	0	4
IDH1	5	0	0	5
Vpr	4	0	0	4
Solute carrier family 22 member 8	0	1	0	2
Epidermal growth factor receptor	0	2	0	2
Thymidylate synthase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
Aldo-keto reductase family 1 member C3	0	2	0	2
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Aldo-keto reductase family 1 member C1	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
aryl hydrocarbon receptor	7	0	0	7
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	1	0	2
Albumin	0	0	1	1
Prostaglandin G/H synthase 1	0	2	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Caspase-1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
Dipeptidyl peptidase 9	0	1	0	1
Dipeptidyl peptidase IV	0	1	0	1
Cytochrome P450 1A2	0	2	1	4
POU domain, class 2, transcription factor 2	0	1	0	1
Cytochrome P450 2D6	0	2	1	4
Muscarinic acetylcholine receptor M1	0	1	0	1
POU domain, class 2, transcription factor 1	0	1	0	1
Dipeptidyl peptidase 4	0	2	1	3
Prolyl endopeptidase	0	1	0	1
Prolyl endopeptidase FAP	0	1	0	1
Prolyl endopeptidase FAP	0	1	0	1
Dipeptidyl peptidase 8	0	1	0	1
Dipeptidyl peptidase 9	0	1	0	1
Dipeptidyl peptidase 2	0	1	0	1
streptokinase A precursor	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Estrogen receptor	0	0	1	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	4	0	4
Amine oxidase [flavin-containing] B	0	3	0	3
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
Cytochrome P450 2C19	0	1	1	3
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
50S ribosomal protein L36 2	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	1	1
Renin	0	1	0	1
Prothrombin	0	1	0	1
Coagulation factor X	0	2	0	2
Plasminogen	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Cationic trypsin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	0	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	4	0	0	4
caspase 7, apoptosis-related cysteine protease	3	0	0	3
hypothetical protein, conserved	2	0	0	2
isocitrate dehydrogenase 1, partial	2	0	0	2
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
caspase-3	3	0	0	3
thyroid stimulating hormone receptor	4	0	0	4
activating transcription factor 6	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
thyroid hormone receptor beta isoform a	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	1	0	0	1
mitogen-activated protein kinase 1	3	0	0	3
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	3	0	3
Cruzipain	0	1	0	1
Alpha-synuclein	2	1	0	3
Alpha-1A adrenergic receptor	0	4	0	4
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Nuclear receptor ROR-gamma	2	1	1	4
Snake venom metalloproteinase BaP1	0	1	0	1
NAD(+) hydrolase SARM1	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Gamma-aminobutyric acid	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Free fatty acid receptor 1	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Carbonic anhydrase 2	0	2	1	3
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Steryl-sulfatase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	2	2	5
Peroxisome proliferator-activated receptor gamma	0	1	1	2
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	1	2
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
Class D beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase 9	0	1	1	2
nonstructural protein 1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphodiesterase	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	1	3
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
Beta-lactamase	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	2
Cytochrome P450 2B6	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase L1 type 3	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Protein Rev	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Parkin	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Adenosine receptor A3	0	2	0	2
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	2	0	2
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	2	0	2
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (81)

Protein Targets (810)

Fournier Disease

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (81)

Drugs Studied (79)

Protein Targets (810)