metronidazole has been researched along with Acute Rheumatic Fever in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The knowledge of adverse effects of antibiotics was greatest for tooth discoloration which is related to tetracycline." | 3.80 | Antibiotics prescription in Nigerian dental healthcare services. ( Azodo, CC; Ojehanon, PI, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Azodo, CC | 1 |
| Ojehanon, PI | 1 |
| Seggie, J | 1 |
2 other studies available for metronidazole and Acute Rheumatic Fever
| Article | Year |
|---|---|
Antibiotics prescription in Nigerian dental healthcare services.
Topics: Acquired Immunodeficiency Syndrome; Amoxicillin; Anaphylaxis; Anti-Bacterial Agents; Antibiotic Prop | 2014 |
Fusobacterium endocarditis treated with metronidazole.
Topics: Adult; Ampicillin; Drug Therapy, Combination; Endocarditis, Bacterial; Fusobacterium Infections; Hum | 1978 |