metronidazole has been researched along with Colonic Diverticulitis in 21 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "12." | 2.90 | One-day versus four-day antibiotic treatment for acute right colonic uncomplicated diverticulitis: A randomized clinical trial. ( Lee, BH; Park, HC; Park, JH, 2019) |
| "Pyoderma gangrenosum is characteristically associated with inflammatory bowel disease." | 2.72 | Multifocal pyoderma gangrenosum secondary to subclinical diverticulitis: case report and brief literature review. ( Álvarez-Salafranca, M; Bularca, EA; Espuelas-Monge, M; Lapeña-Casado, A; Rivera-Fuertes, I; Soria-Navarro, J, 2021) |
| "Nonoperative treatment of acute diverticulitis with extraluminal air is safe and effective in patients with a small amount of distant intraperitoneal air or pericolic air without clinical signs of peritonitis." | 1.40 | Nonoperative management of perforated diverticulitis with extraluminal air is safe and effective in selected patients. ( Leppäniemi, AK; Mentula, PJ; Sallinen, VJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Arezzo, A | 1 |
| Nicotera, A | 1 |
| Bonomo, LD | 1 |
| Olandese, F | 1 |
| Veglia, S | 1 |
| Ferguglia, A | 1 |
| Pentassuglia, G | 1 |
| Mingrone, G | 1 |
| Morino, M | 1 |
| Álvarez-Salafranca, M | 1 |
| Bularca, EA | 1 |
| Rivera-Fuertes, I | 1 |
| Lapeña-Casado, A | 1 |
| Soria-Navarro, J | 1 |
| Espuelas-Monge, M | 1 |
| Park, JH | 1 |
| Park, HC | 3 |
| Lee, BH | 3 |
| Sallinen, VJ | 1 |
| Mentula, PJ | 1 |
| Leppäniemi, AK | 1 |
| Sadarangani, SP | 1 |
| Cunningham, SA | 1 |
| Jeraldo, PR | 1 |
| Wilson, JW | 1 |
| Khare, R | 1 |
| Patel, R | 1 |
| Steurer, J | 1 |
| Chang, MY | 1 |
| Batjom, E | 1 |
| Franck, L | 1 |
| Dubost, C | 1 |
| Rouquette-Vincenti, I | 1 |
| Michalski, T | 1 |
| Kim, BS | 1 |
| Held, M | 1 |
| Tursi, A | 1 |
| Elisei, W | 1 |
| Brandimarte, G | 1 |
| Giorgetti, GM | 1 |
| Inchingolo, CD | 1 |
| Nenna, R | 1 |
| Picchio, M | 1 |
| Giorgio, F | 1 |
| Ierardi, E | 1 |
| Kolyvanos Naumann, U | 1 |
| Käser, L | 1 |
| Vetter, W | 1 |
| Ea, HK | 1 |
| Zeller, V | 1 |
| Chicheportiche, V | 1 |
| Desplaces, N | 1 |
| Ziza, JM | 1 |
| Descloux, A | 1 |
| Wiens, M | 1 |
| Menzel, J | 1 |
| Bauer, J | 1 |
| von Pritzbuer, E | 1 |
| Klempa, I | 1 |
| Ahmed, A | 1 |
| Sridharan, GV | 1 |
| Wilkinson, SP | 1 |
| Primrose, WR | 1 |
| Entner, M | 1 |
| Heimberger, H | 1 |
| Miller, B | 1 |
| Martini, GA | 1 |
| Balikian, JP | 1 |
| Uthman, SM | 1 |
| Khouri, NF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis[NCT03496090] | 134 participants (Actual) | Interventional | 2018-04-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Colonic Diverticulitis
| Article | Year |
|---|---|
Multifocal pyoderma gangrenosum secondary to subclinical diverticulitis: case report and brief literature review.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Clindamycin; Diagnosis, Differential; Diverticulitis, Colo | 2021 |
[Diverticulitis (acute)/diverticulosis of the colon].
Topics: Acute Disease; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Diagnosis, Differential; | 2005 |
[What is secured in the therapy of chronic inflammatory colonic diseases?].
Topics: Administration, Topical; Amebiasis; Azathioprine; Chronic Disease; Colitis; Colitis, Ulcerative; Col | 1974 |
3 trials available for metronidazole and Colonic Diverticulitis
| Article | Year |
|---|---|
One-day versus four-day antibiotic treatment for acute right colonic uncomplicated diverticulitis: A randomized clinical trial.
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Bacterial Agents; Cefmetazole; Diverticulitis, Colonic; | 2019 |
Topics: Acute Disease; Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Ciprofloxacin; C | 2017 |
[Perioperative use of ampicillin/sulbactam, cefoxitin and piperacillin/ metronidazole in elective colon and rectal surgery. A prospective randomized quality assurance study of 422 patients].
Topics: Aged; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Cefoxitin; Colitis, Ulcerative; Colon | 1993 |
15 other studies available for metronidazole and Colonic Diverticulitis
| Article | Year |
|---|---|
Outcomes of surgical treatment of diverticular abscesses after failure of antibiotic therapy.
Topics: Abdominal Abscess; Abscess; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Ci | 2023 |
Nonoperative management of perforated diverticulitis with extraluminal air is safe and effective in selected patients.
Topics: Acute Disease; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; C | 2014 |
Metronidazole- and carbapenem-resistant bacteroides thetaiotaomicron isolated in Rochester, Minnesota, in 2014.
Topics: Abscess; Adult; Anti-Bacterial Agents; Bacterial Proteins; Bacteroides; Bacteroides Infections; beta | 2015 |
Nonoperative management of right colonic diverticulitis using radiologic evaluation.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Cellulitis; Cephalosporins; Colon, Ascending; Divert | 2010 |
[When an antibiotic becomes toxic].
Topics: Aged; Anti-Bacterial Agents; Diverticulitis, Colonic; Female; Humans; Metronidazole; Peripheral Nerv | 2009 |
[70 year old female patient with unclear skin color].
Topics: Abdominal Pain; Aged; Cholestasis; Diagnosis, Differential; Diverticulitis, Colonic; Face; Female; H | 2009 |
Management of right colonic uncomplicated diverticulitis: outpatient versus inpatient management.
Topics: Adult; Ambulatory Surgical Procedures; Anti-Infective Agents; Bed Rest; Cephalosporins; Diverticulit | 2011 |
[Peritonitis in diverticulitis. How to treat in ambulatory care?].
Topics: Ambulatory Care; Anti-Bacterial Agents; Diverticulitis, Colonic; Drug Therapy, Combination; Humans; | 2011 |
Mucosal expression of basic fibroblastic growth factor, Syndecan 1 and tumor necrosis factor-alpha in diverticular disease of the colon: a case-control study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Case | 2012 |
Polybacterial pyomyositis following laparoscopic colectomy for complicated diverticulosis.
Topics: Abdominal Abscess; Aged; Anti-Bacterial Agents; Ceftriaxone; Colectomy; Colon, Sigmoid; Diverticulit | 2007 |
[Paraduodenal hernia: case report of an operative accidental diagnosis].
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Diverticulitis, Colonic; Duodenal D | 2007 |
Acute diverticulitis.
Topics: Acute Disease; Anti-Infective Agents; Ciprofloxacin; Diverticulitis, Colonic; Drug Therapy, Combinat | 1998 |
Pyogenic liver abscess in the elderly.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Cholelithiasis; Diagnosis, Differential; Diverticuli | 1990 |
One row anastomosis in colonic operations with antibiotic prophylaxis.
Topics: Adolescent; Adult; Aged; Colon; Colonic Neoplasms; Diverticulitis, Colonic; Humans; Metronidazole; M | 1985 |
Intestinal amebiasis. A roentgen analysis of 19 cases including 2 case reports.
Topics: Abscess; Aged; Cecal Diseases; Colitis, Ulcerative; Colonic Diseases; Colonic Neoplasms; Diagnosis, | 1974 |