Granulomatosis, Orofacial

A condition characterized by persistent or recurrent labial enlargement, ORAL ULCER, and other orofacial manifestations in the absence of identifiable CROHN DISEASE; or SARCOIDOSIS. Among experts there is disagreement on whether orofacial granulomatosis is a distinct clinical disorder or an initial presentation of Crohn disease.

Synonym
Granulomatosis, Orofacial
Orofacial Granulomatosis

Excerpt	Reference
"Orofacial granulomatosis is a generic term applied to manifestations of several diseases including sarcoidosis, Crohn's disease, Melkersson-Rosenthal syndrome, cheilitis granulomatosa of Miescher, tuberculosis and foreign-body reactions."	( De Sousa, SC; Galletta, VC; Lemos, CA; Martini, MZ; Migliari, DA; Pereira, EM, 2010)
"Orofacial granulomatosis is an uncommon disorder, but has been increasingly recognized in the past decade."	( Bhargava, D; Deshpande, A; Neelakandan, RS; Thomas, TK, 2011)
"Orofacial granulomatosis is a clinicopathologic entity characterized by chronic swelling of the lip and possible soft tissues in the orofacial region owing to granulomatous inflammation of unknown cause."	( Arenbergerová, M; Machovcová, A; Pelclová, D; Petanová, J; Procházková, J; Tomka, M, 2011)
"The term orofacial granulomatosis is conventionally used to describe patients with granulomatous lesions affecting the orofacial tissues, in absence of intestinal lesions."	( Bersanini, C; Cont, G; Fontana, M; Lazzerini, M; Martelossi, S; Taddio, A; Ventura, A; Ventura, G; Zuin, G, 2015)

Excerpt	Reference
"She was diagnosed with orofacial granulomatosis (OFG) and was treated conservatively for 7 years, with no evidence of systemic illness."	( Henson, S; Jennings, VC; Williams, L, 2015)
"Treatment of orofacial granulomatosis (OFG) is difficult and unpredictable, and currently there is not a treatment with guaranteed success."	( Atkin, PA; Simms, ML, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	8 (16.33)	18.1394
2010's	33 (67.35)	28.8240
2020's	8 (16.33)	9.53

Drug	Relationship Strength	Studies
benzoic acid	low	1
aspirin	low	1
azathioprine	low	2
chlorambucil	low	1
chloroquine	low	1
clofazimine	low	2
dapsone	low	1
hydroxychloroquine	low	2
ibuprofen	low	1
indomethacin	low	1
methyl salicylate	low	1
metronidazole	low	2
thalidomide	low	3
prednisolone	low	1
prednisone	low	2
triamcinolone acetonide	low	3
methylprednisolone	low	1
benzoyl peroxide	low	1
acrolein	low	1
meglumine	low	1
erythromycin	low	3
mercury	low	2
triamcinolone	low	3
meglumine antimoniate	low	1
naproxen	low	1
inositol 3-phosphate	low	15
tacrolimus	low	1
mycophenolic acid	low	1
zithromax	low	2
cinnamaldehyde	low	1
indomethacin farnesil	low	1
isotretinoin	low	1
clobetasol	low	1
cinnamyl alcohol	low	1
indium	low	1
mocetinostat	low	1
apremilast	low	1
minocycline	low	2

Protein Targets (521)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
thyroid stimulating hormone receptor	9	0	0	9
peroxisome proliferator activated receptor gamma	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
Transient receptor potential cation channel subfamily A member 1	0	0	2	3
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 3A4	0	6	0	6
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	8	0	8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Cytochrome P450 2C19	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Carboxylic ester hydrolase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	7	0	0	7
thioredoxin reductase	6	0	0	6
GLS protein	4	0	0	4
AR protein	19	0	0	19
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
EWS/FLI fusion protein	9	0	0	9
glucocorticoid receptor [Homo sapiens]	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
estrogen-related nuclear receptor alpha	19	0	0	19
estrogen nuclear receptor alpha	27	0	0	27
cytochrome P450 2D6	6	0	0	6
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	11	0	0	11
Rac1 protein	0	0	1	1
IDH1	7	0	0	7
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Bloom syndrome protein isoform 1	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	4	0	0	4
DNA polymerase kappa isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	3	0	0	3
Prostaglandin-H2 D-isomerase	0	2	0	2
ATP-binding cassette sub-family C member 3	0	16	0	16
Multidrug resistance-associated protein 4	0	16	0	16
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 1	0	4	0	5
Prostaglandin G/H synthase 2	0	3	0	4
Bile salt export pump	0	18	0	18
Epidermal growth factor receptor	0	3	0	3
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	7	0	8
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Adenosine receptor A1	0	4	0	4
Adenosine receptor A2a	0	4	0	4
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	8	1	9
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	8	0	0	8
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	1	0	6
Prostaglandin G/H synthase 2	0	7	0	7
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Canalicular multispecific organic anion transporter 1	0	16	0	16
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Ferritin light chain	3	0	0	3
acetylcholinesterase	6	0	0	6
phosphopantetheinyl transferase	2	0	0	2
RAR-related orphan receptor gamma	11	0	0	11
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	1	0	0	1
SMAD family member 3	6	0	0	6
TDP1 protein	17	0	0	17
GLI family zinc finger 3	15	0	0	15
Microtubule-associated protein tau	4	0	0	4
thioredoxin glutathione reductase	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
retinoid X nuclear receptor alpha	12	0	0	12
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	12	0	0	12
G	7	0	0	7
polyprotein	1	0	0	1
P53	1	0	0	1
arylsulfatase A	4	0	0	4
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
thyroid stimulating hormone receptor	3	0	0	3
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	4	0	0	4
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
thyroid hormone receptor beta isoform 2	13	0	0	13
heat shock protein beta-1	6	0	0	6
geminin	16	0	0	16
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	7	0	0	7
lamin isoform A-delta10	15	0	0	15
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Cellular tumor antigen p53	13	0	0	13
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
Glutamate receptor 2	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
GABA theta subunit	5	0	0	5
Inositol hexakisphosphate kinase 1	7	0	0	7
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Protein-arginine deiminase type-4	0	4	0	4
cytochrome P450 2C9, partial	7	0	0	7
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Luciferase	7	0	0	7
estrogen receptor 2 (ER beta)	6	0	0	6
Polyphenol oxidase 2	0	3	0	3
D-amino-acid oxidase	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Tyrosinase	0	1	0	1
D-amino-acid oxidase	0	2	1	3
Metabotropic glutamate receptor 5	0	0	1	1
Alpha-glucosidase MAL12	0	1	0	1
Monocarboxylate transporter 1	0	0	0	1
Beta-lactamase	0	1	1	2
D-aspartate oxidase	0	1	0	1
Serine racemase	0	1	0	1
thyroid hormone receptor beta isoform a	5	0	0	5
Spike glycoprotein	6	1	2	9
NFKB1 protein, partial	3	0	0	3
GALC protein	1	0	0	1
Thrombopoietin	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
caspase-3	1	0	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
chromobox protein homolog 1	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Carbonic anhydrase 12	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	4
ATP-dependent phosphofructokinase	2	0	0	2
PPM1D protein	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	1	0	0	1
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	1	0	1
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	2	2	4
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	2	2	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	2	0	2
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Serine/threonine-protein kinase mTOR	0	2	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
67.9K protein	7	0	0	7
shiga toxin 1 variant A subunit	1	0	0	1
shiga toxin 1 B subunit	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
mitogen-activated protein kinase 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cell division protein FtsZ	0	1	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
USP1 protein, partial	3	0	0	3
cytochrome P450 2D6 isoform 1	2	0	0	2
transcriptional regulator ERG isoform 3	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
streptokinase A precursor	0	0	3	3
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	0	1	1
ATP-dependent translocase ABCB1	0	4	0	4
5-hydroxytryptamine receptor 1A	0	0	1	1
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Smad3	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
Dihydrofolate reductase	0	1	0	1
Histamine H2 receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Motilin receptor	0	0	1	1
acid sphingomyelinase	1	0	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
Albumin	0	2	4	6
ATP-dependent translocase ABCB1	0	2	0	2
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
60 kDa heat shock protein, mitochondrial	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 2J2	0	6	0	6
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
10 kDa heat shock protein, mitochondrial	0	1	0	1
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
50S ribosomal protein L36 2	0	2	1	3
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Genome polyprotein	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
nonstructural protein 1	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Albumin	0	1	0	1
Albumin	0	0	1	1
Cholinesterase	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	7
UDP-glucuronosyltransferase 2B7	0	0	0	2
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	2	0	3
Prostaglandin G/H synthase 2	0	3	0	5
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	4	0	4
Caspase-3	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	2	0	2
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
TAR DNA-binding protein 43	5	0	0	5
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	5
Solute carrier family 22 member 8	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, Cruzipain	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
progesterone receptor	7	0	0	7
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	3	0	3
regulator of G-protein signaling 4	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Adenosine receptor A3	0	2	0	2
Retinoic acid receptor alpha	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Cellular retinoic acid-binding protein 1	0	0	1	1
Mitogen-activated protein kinase 14	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	10	2	17
Glycine receptor subunit alpha-1	0	10	0	10
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
glp-1 receptor, partial	3	0	0	3
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-synuclein	1	0	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Hormone-sensitive lipase	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	1	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
procathepsin L isoform 1 preproprotein	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (49)

Protein Targets (521)

Granulomatosis, Orofacial

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (49)

Drugs Studied (41)

Protein Targets (521)