metronidazole has been researched along with Cancer of Pelvis in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ito, Y | 1 |
| Nakayama, H | 1 |
| Niitsu, Y | 1 |
| Kaneko, N | 1 |
| Otsuka, M | 1 |
| Sawada, Y | 1 |
| Takeuchi, Y | 1 |
| Sekido, N | 1 |
| Pui, WC | 1 |
| Chieng, TH | 1 |
| Siow, SL | 1 |
| Nik Abdullah, NA | 1 |
| Sagap, I | 1 |
| Antonelli, D | 1 |
| Kustrup, JF | 1 |
| Denton, AS | 1 |
| Andreyev, HJ | 1 |
| Forbes, A | 1 |
| Maher, EJ | 1 |
2 reviews available for metronidazole and Cancer of Pelvis
| Article | Year |
|---|---|
Large bowel obstruction due to intrauterine device: associated pelvic inflammatory disease.
Topics: Actinomycosis; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Colostomy; Diagnosis, Diffe | 1999 |
Systematic review for non-surgical interventions for the management of late radiation proctitis.
Topics: Administration, Rectal; Anti-Inflammatory Agents; Chronic Disease; Combined Modality Therapy; Cross- | 2002 |
1 trial available for metronidazole and Cancer of Pelvis
| Article | Year |
|---|---|
A Randomized Controlled Trial of Novel Treatment for Hemorrhagic Radiation Proctitis.
Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Disinfectants; Electrocoagulation; Female; | 2020 |
1 other study available for metronidazole and Cancer of Pelvis
| Article | Year |
|---|---|
The first case of Veillonella atypica bacteremia in a patient with renal pelvic tumor.
Topics: Aged; Bacteremia; Female; Humans; Metronidazole; Pelvic Neoplasms; Veillonella | 2022 |