metronidazole has been researched along with Abortion, Septic in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Abortion, Septic: Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characterized by FEVER, uterine tenderness, and foul discharge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The latter category includes pelvic inflammatory disease, pelvic thrombophlebitis, septic abortion, and premature rupture of the membranes." | 2.36 | Infections in the female genital tract. ( Gall, SA, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fouks, Y | 1 |
| Samueloff, O | 1 |
| Levin, I | 1 |
| Many, A | 1 |
| Amit, S | 1 |
| Cohen, A | 1 |
| Savaris, RF | 1 |
| de Moraes, GS | 1 |
| Cristovam, RA | 1 |
| Braun, RD | 1 |
| Gall, SA | 1 |
| Lang, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Clinical Trial Between Clindamycin Once and Thrice a Day in Septic Abortion.[NCT02309346] | Phase 4 | 190 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Abortion, Septic
| Article | Year |
|---|---|
Infections in the female genital tract.
Topics: Abortion, Septic; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cephalosporins; En | 1983 |
1 trial available for metronidazole and Abortion, Septic
| Article | Year |
|---|---|
Are antibiotics necessary after 48 hours of improvement in infected/septic abortions? A randomized controlled trial followed by a cohort study.
Topics: Abortion, Septic; Administration, Oral; Adult; Anti-Bacterial Agents; Clindamycin; Cohort Studies; D | 2011 |
2 other studies available for metronidazole and Abortion, Septic
| Article | Year |
|---|---|
Assessing the effectiveness of empiric antimicrobial regimens in cases of septic/infected abortions.
Topics: Abortion, Septic; Adult; Ampicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Female; Follo | 2020 |
[Clinico-therapeutic aspects of anaerobic infections in gynecology and obstetrics].
Topics: Abortion, Septic; Abscess; Anaerobiosis; Azlocillin; Bacterial Infections; Cefoxitin; Cefuroxime; Ce | 1980 |