metronidazole has been researched along with Infections, Ureaplasma in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As metronidazole effectively treats full BV, but is ineffective against other forms of AVF, the present data may help to explain why its use to prevent PTB has not been successful in most studies." | 1.35 | Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. ( Bellen, G; Donders, GG; Reybrouck, R; Riphagen, I; Van Calsteren, K; Van den Bosch, T; Van Lierde, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dinglas, C | 1 |
| Chavez, M | 1 |
| Vintzileos, A | 1 |
| Donders, GG | 1 |
| Van Calsteren, K | 1 |
| Bellen, G | 1 |
| Reybrouck, R | 1 |
| Van den Bosch, T | 1 |
| Riphagen, I | 1 |
| Van Lierde, S | 1 |
| Ogawa, Y | 1 |
| Hatano, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preventing Preterm Birth With Probiotics - Pilot Randomised Trial[NCT02692820] | 304 participants (Actual) | Interventional | 2016-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Infections, Ureaplasma
| Article | Year |
|---|---|
[Urethritis].
Topics: Anti-Bacterial Agents; Antitrichomonal Agents; Chlamydia Infections; Chlamydia trachomatis; Diagnosi | 1999 |
2 other studies available for metronidazole and Infections, Ureaplasma
| Article | Year |
|---|---|
Resolution of intra-amniotic sludge after antibiotic administration in a patient with short cervix and recurrent mid-trimester loss.
Topics: Abortion, Habitual; Adult; Anti-Bacterial Agents; Cerclage, Cervical; Cervix Uteri; Chorioamnionitis | 2019 |
Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy.
Topics: Adult; Anti-Infective Agents; Female; Humans; Metronidazole; Mycoplasma hominis; Mycoplasma Infectio | 2009 |