Page last updated: 2024-10-31

metronidazole and Infections, Ureaplasma

metronidazole has been researched along with Infections, Ureaplasma in 3 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"As metronidazole effectively treats full BV, but is ineffective against other forms of AVF, the present data may help to explain why its use to prevent PTB has not been successful in most studies."1.35Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. ( Bellen, G; Donders, GG; Reybrouck, R; Riphagen, I; Van Calsteren, K; Van den Bosch, T; Van Lierde, S, 2009)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dinglas, C1
Chavez, M1
Vintzileos, A1
Donders, GG1
Van Calsteren, K1
Bellen, G1
Reybrouck, R1
Van den Bosch, T1
Riphagen, I1
Van Lierde, S1
Ogawa, Y1
Hatano, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Preventing Preterm Birth With Probiotics - Pilot Randomised Trial[NCT02692820]304 participants (Actual)Interventional2016-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for metronidazole and Infections, Ureaplasma

ArticleYear
[Urethritis].
    Ryoikibetsu shokogun shirizu, 1999, Issue:23 Pt 1

    Topics: Anti-Bacterial Agents; Antitrichomonal Agents; Chlamydia Infections; Chlamydia trachomatis; Diagnosi

1999

Other Studies

2 other studies available for metronidazole and Infections, Ureaplasma

ArticleYear
Resolution of intra-amniotic sludge after antibiotic administration in a patient with short cervix and recurrent mid-trimester loss.
    American journal of obstetrics and gynecology, 2019, Volume: 221, Issue:2

    Topics: Abortion, Habitual; Adult; Anti-Bacterial Agents; Cerclage, Cervical; Cervix Uteri; Chorioamnionitis

2019
Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy.
    BJOG : an international journal of obstetrics and gynaecology, 2009, Volume: 116, Issue:10

    Topics: Adult; Anti-Infective Agents; Female; Humans; Metronidazole; Mycoplasma hominis; Mycoplasma Infectio

2009