metronidazole has been researched along with Pituitary Diseases in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Pituitary Diseases: Disorders involving either the ADENOHYPOPHYSIS or the NEUROHYPOPHYSIS. These diseases usually manifest as hypersecretion or hyposecretion of PITUITARY HORMONES. Neoplastic pituitary masses can also cause compression of the OPTIC CHIASM and other adjacent structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The patient continues to have pituitary insufficiency and treated with oral hydrocortisone." | 1.46 | Pituitary abscess. ( Al Agha, RAMB; Al Salman, JM; Helmy, M, 2017) |
| "Gradual development of diplopia over 6 months was the first clinical manifestation." | 1.29 | [Pituitary abscess, treated by medication]. ( Ba Zeze, V; Boni, N; Datie, A; Dechambenoit, G; Grunitzky, EK; Kakou, M; Santini, JJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al Salman, JM | 1 |
| Al Agha, RAMB | 1 |
| Helmy, M | 1 |
| Naama, O | 1 |
| Gazzaz, M | 1 |
| Boulahroud, O | 1 |
| Elmoustarchid, B | 1 |
| Dechambenoit, G | 1 |
| Datie, A | 1 |
| Grunitzky, EK | 1 |
| Ba Zeze, V | 1 |
| Boni, N | 1 |
| Kakou, M | 1 |
| Santini, JJ | 1 |
1 review available for metronidazole and Pituitary Diseases
| Article | Year |
|---|---|
Infection of a Rathke cleft cyst: a rare cause of pituitary abscess.
Topics: Anti-Infective Agents; Brain; Brain Abscess; Ceftriaxone; Central Nervous System Cysts; Debridement; | 2014 |
2 other studies available for metronidazole and Pituitary Diseases
| Article | Year |
|---|---|
Pituitary abscess.
Topics: Anti-Bacterial Agents; Antiprotozoal Agents; Brain Abscess; Ceftriaxone; Diagnosis, Differential; Hu | 2017 |
[Pituitary abscess, treated by medication].
Topics: Abscess; Adult; Cefotaxime; Diplopia; Drug Therapy, Combination; Humans; Male; Metronidazole; Netilm | 1993 |