metronidazole has been researched along with EHS Tumor in 14 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combination of the radiosensitizer, metronidazole, and the radioprotector, dimethyl sulfoxide (DMSO), was tested for its effects on the radiation tolerance of rat skin and on the radiosensitivity of the BA1112 rhabdomyosarcoma." | 3.66 | Effect of combined metronidazole and DMSO on tumour control and skin tolerance in the rat. ( Fischer, JJ; Lo, PS; Moulder, JE, 1978) |
| "For melphalan, neither pretreatment agent produced any change in tumor response." | 1.26 | Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU. ( Twentyman, P; Workman, P, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (92.86) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Siemann, DW | 1 |
| Twentyman, P | 1 |
| Workman, P | 1 |
| Vepkhvadze, NR | 1 |
| Infante, GA | 1 |
| Gonzalez, P | 1 |
| Cruz, D | 1 |
| Correa, J | 1 |
| Myers, JA | 1 |
| Ahmad, MF | 1 |
| Whitter, WL | 1 |
| Santos, A | 1 |
| Neta, P | 1 |
| Tannock, IF | 2 |
| Rauth, AM | 2 |
| Chin, J | 1 |
| Marchow, L | 1 |
| Paciga, J | 1 |
| Moulder, JE | 1 |
| Lo, PS | 1 |
| Fischer, JJ | 1 |
| Whitmore, GF | 1 |
| Kaufman, K | 1 |
| Abrosimov, AIu | 1 |
| Skoropad, VIu | 1 |
| Amosov, IS | 1 |
| Malygina, AI | 1 |
| Morozova, TG | 1 |
| Kurpeshev, OK | 1 |
| Begg, AC | 1 |
| Sheldon, PW | 1 |
| Foster, JL | 1 |
2 reviews available for metronidazole and EHS Tumor
| Article | Year |
|---|---|
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs | 1976 |
The potential for radiation sensitizers and possible strategy for use.
Topics: Animals; Female; Humans; Hypoxia; Laryngeal Neoplasms; Metronidazole; Nitro Compounds; Ovarian Neopl | 1975 |
12 other studies available for metronidazole and EHS Tumor
| Article | Year |
|---|---|
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanidazole; Female; Leukocyte | 1982 |
Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Synergism; Drug | 1982 |
[Dynamics of the distribution of metronidazole in animals and in sarcoma 45].
Topics: Animals; Male; Metronidazole; Rats; Sarcoma, Experimental; Tissue Distribution | 1982 |
Radiation sensitization and chemical studies on isoindole-4,7-diones.
Topics: Animals; Dose-Response Relationship, Radiation; Female; Free Radicals; Indolequinones; Indoles; Metr | 1982 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: cyclophosphamide and BCNU.
Topics: Animals; Body Weight; Carmustine; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Leukocy | 1980 |
Testing of hypoxic cell radiosensitizers in vivo.
Topics: Animals; Cell Survival; Metronidazole; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Radiation-Se | 1978 |
Effect of combined metronidazole and DMSO on tumour control and skin tolerance in the rat.
Topics: Animals; Dimethyl Sulfoxide; Metronidazole; Radiation Dosage; Radiation Tolerance; Rats; Rhabdomyosa | 1978 |
In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.
Topics: Animals; Cell Division; Cell Survival; Dose-Response Relationship, Radiation; Hypoxia; Kinetics; Let | 1975 |
[The morphological characteristics of sarcoma M1 cells before and after irradiation].
Topics: Animals; Cell Death; Dose-Response Relationship, Radiation; Metronidazole; Microscopy, Electron; Nec | 1991 |
[Microcirculation of tumors and adjacent tissues during combined exposure to metronidazole and hyperthermia].
Topics: Adenocarcinoma; Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Metronidazole; Mi | 1987 |
Demonstration of radiosensitization of hypoxic cells in solid tumours by metronidazole.
Topics: Animals; Dose-Response Relationship, Radiation; Hypoxia; Iodine Radioisotopes; Mammary Neoplasms, Ex | 1974 |