An agonist that selectively binds to and activates a glucocorticoid receptor.
ChEBI ID: 63562
| Member | Definition | Class |
|---|---|---|
| dexamethasone 21-phosphate | A steroid phosphate that is the 21-O-phospho derivative of dexamethasone. | dexamethasone phosphate |
| dexamethasone sodium phosphate | An organic sodium salt which is the disodium salt of dexamethasone phosphate. | dexamethasone sodium phosphate |
| methylprednisolone suleptanate | An organic sodium salt that is the monosodium salt of methylprednisolone 21-suleptanic acid ester. It is a prodrug of methylprednisolone developed by Pharmacia Corp for the treatment of asthma. | methylprednisolone suleptanate |
| prednisolone phosphate | A synthetic glucocorticoid resulting from the formal condensation of the 21-hydroxy group of prednisolone with one of the hydroxy groups of phosphoric acid. It is a prodrug for prednisolone that is activated in vivo by phosphatases. | prednisolone phosphate |
| tixocortol pivalate | The pivalate thioester of tixocortol. | tixocortol pivalate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 185 (27.74) | 18.7374 |
| 1990's | 112 (16.79) | 18.2507 |
| 2000's | 135 (20.24) | 29.6817 |
| 2010's | 197 (29.54) | 24.3611 |
| 2020's | 38 (5.70) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 126 (17.55%) | 5.53% |
| Reviews | 16 (2.23%) | 6.00% |
| Case Studies | 75 (10.45%) | 4.05% |
| Observational | 4 (0.56%) | 0.25% |
| Other | 497 (69.22%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 0.9522 | 9 | 14 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.0298 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.0298 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.5616 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 2.3731 | 8 | 10 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.1726 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.0576 | 3 | 6 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.1132 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 2.0133 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 6.3668 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.1132 | 1 | 1 |