metronidazole has been researched along with Cancer of Sigmoid in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alidjinou, EK | 1 |
| Bonnet, I | 1 |
| Canis, F | 1 |
| Dewulf, G | 1 |
| Mazars, E | 1 |
| Cattoen, C | 1 |
| Torrijo Gómez, I | 1 |
| Uribe Quintana, N | 1 |
| Catalá Llosa, J | 1 |
| Raga Vázquez, J | 1 |
| Sellés Dechent, R | 1 |
| Martín Dieguez, MC | 1 |
| Báguena Requena, G | 1 |
| Asencio Arana, F | 1 |
| Conscience, I | 1 |
| Perceau, G | 1 |
| Le Berruyer, PY | 1 |
| Bernard, P | 1 |
| Tokuyama, H | 1 |
| Higashi, F | 1 |
| Tamaki, H | 1 |
| Kunishoh, T | 1 |
| Tamaki, Y | 1 |
| Kawai, J | 1 |
| Sakatsuji, K | 1 |
| Itoh, H | 1 |
| Nakayama, T | 1 |
| Nishioka, S | 1 |
1 review available for metronidazole and Cancer of Sigmoid
| Article | Year |
|---|---|
[A case of amebic liver abscess with colonic carcinoma].
Topics: Adenocarcinoma; Female; Humans; Liver Abscess, Amebic; Lymphatic Metastasis; Metronidazole; Middle A | 1993 |
3 other studies available for metronidazole and Cancer of Sigmoid
| Article | Year |
|---|---|
[Gardnerella vaginalis bacteremia in a male patient].
Topics: Adenocarcinoma; Amikacin; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Bac | 2013 |
[Fulminant Clostridium difficile colitis].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Clostridioides difficile; Colectomy; Enterocol | 2016 |
[Bilateral breast bacterial cellulite secondary to Streptococcus agalactiae septicemia].
Topics: Adenocarcinoma; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Breast Diseases; Ce | 2006 |