metronidazole has been researched along with Cholangiocarcinoma in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Cholangiocarcinoma: A malignant tumor arising from the epithelium of the BILE DUCTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole (MNZ) is a common antibiotic that exerts disulfiram-like effects when taken together with alcohol." | 5.48 | Combined Gemcitabine and Metronidazole Is a Promising Therapeutic Strategy for Cancer Stem-like Cholangiocarcinoma. ( Kawabe, K; Kawamoto, M; Koya, N; Morisaki, T; Nakagawa, S; Nakamura, M; Onishi, H; Tanaka, H; Umebayashi, M, 2018) |
| "Metronidazole (MNZ) is a common antibiotic that exerts disulfiram-like effects when taken together with alcohol." | 1.48 | Combined Gemcitabine and Metronidazole Is a Promising Therapeutic Strategy for Cancer Stem-like Cholangiocarcinoma. ( Kawabe, K; Kawamoto, M; Koya, N; Morisaki, T; Nakagawa, S; Nakamura, M; Onishi, H; Tanaka, H; Umebayashi, M, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawamoto, M | 1 |
| Umebayashi, M | 1 |
| Tanaka, H | 1 |
| Koya, N | 1 |
| Nakagawa, S | 1 |
| Kawabe, K | 1 |
| Onishi, H | 1 |
| Nakamura, M | 1 |
| Morisaki, T | 1 |
| Kim, JH | 2 |
| Jung, ES | 1 |
| Jeong, SH | 1 |
| Kim, JS | 1 |
| Ku, YS | 1 |
| Hahm, KB | 1 |
| Kim, YS | 1 |
2 other studies available for metronidazole and Cholangiocarcinoma
| Article | Year |
|---|---|
Combined Gemcitabine and Metronidazole Is a Promising Therapeutic Strategy for Cancer Stem-like Cholangiocarcinoma.
Topics: Aldehyde Dehydrogenase; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Biomark | 2018 |
A case of emphysematous hepatitis with spontaneous pneumoperitoneum in a patient with hilar cholangiocarcinoma.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cefotaxime; | 2012 |