metronidazole has been researched along with Delayed Hypersensitivity in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole administered orally in doses of 20 and 200 mg/kg daily suppressed granuloma formation around Schistosoma mansoni eggs which were injected intravenously and lodged in the pulmonary microvasculature of mice." | 3.65 | Suppression of cell-mediated immunity by metronidazole. ( Grove, DI; Mahmound, AA; Warren, KS, 1977) |
| "Metronidazole (MTZ) is a nitroimidazole antibiotic used mainly for the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa." | 2.47 | Metronidazole and the immune system. ( Ashraf, M; Javeed, A; Riaz, A; Shakir, L, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dilley, M | 1 |
| Geng, B | 1 |
| Shakir, L | 1 |
| Javeed, A | 1 |
| Ashraf, M | 1 |
| Riaz, A | 1 |
| Rockwell, S | 1 |
| Irvin, CG | 1 |
| Neaderland, MH | 1 |
| Grove, DI | 1 |
| Mahmound, AA | 1 |
| Warren, KS | 1 |
| Sullivan, PB | 1 |
| Lunn, PG | 1 |
| Northrop-Clewes, C | 1 |
| Crowe, PT | 1 |
| Marsh, MN | 1 |
| Neale, G | 1 |
2 reviews available for metronidazole and Delayed Hypersensitivity
| Article | Year |
|---|---|
Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole.
Topics: Aminoglycosides; Anaphylaxis; Angioedema; Anti-Bacterial Agents; Clindamycin; Dermatitis, Allergic C | 2022 |
Metronidazole and the immune system.
Topics: Adaptive Immunity; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal Agents; Graf | 2011 |
3 other studies available for metronidazole and Delayed Hypersensitivity
| Article | Year |
|---|---|
Inhibition of delayed hypersensitivity by metronidazole and misonidazole.
Topics: Animals; Dinitrofluorobenzene; Drug Hypersensitivity; Female; Hypersensitivity, Delayed; Male; Metro | 1983 |
Suppression of cell-mediated immunity by metronidazole.
Topics: Animals; Female; Graft Survival; Granuloma; Hypersensitivity, Delayed; Immunity, Cellular; Metronida | 1977 |
Persistent diarrhea and malnutrition--the impact of treatment on small bowel structure and permeability.
Topics: Anti-Bacterial Agents; Antifungal Agents; Blood Proteins; Body Weight; Cell Membrane Permeability; C | 1992 |