metronidazole has been researched along with Cervical Tuberculous Lymphadenitis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case pf pseudomembranous colitis that developed in a patient with tuberculous abdominal lymphadenopathy during treatment with rifampicin." | 1.32 | A case of rifampicin induced pseudomembraneous colitis. ( Akbar, DH; Al-Huzali, AM; Al-Shehri, HZ; Falatah, HI, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Dong, WZ | 1 |
| Shi, J | 1 |
| Chu, P | 1 |
| Liu, RM | 1 |
| Wen, SA | 1 |
| Zhang, TT | 1 |
| Pang, Y | 1 |
| Lu, J | 1 |
| Akbar, DH | 1 |
| Al-Shehri, HZ | 1 |
| Al-Huzali, AM | 1 |
| Falatah, HI | 1 |
| Weber, I | 1 |
| Fabre, J | 1 |
3 other studies available for metronidazole and Cervical Tuberculous Lymphadenitis
| Article | Year |
|---|---|
The putative NAD(P)H Nitroreductase, Rv3131, is the Probable Activating Enzyme for Metronidazole in
Topics: Bacterial Proteins; Humans; Metronidazole; Mycobacterium tuberculosis; NAD; Nitroreductases; Tubercu | 2022 |
A case of rifampicin induced pseudomembraneous colitis.
Topics: Abdominal Pain; Adult; Biopsy, Needle; Colonoscopy; Dose-Response Relationship, Drug; Drug Administr | 2003 |
[Internal medicine conference: tuberculous lymphadenitis of the mediastinum (author's transl)].
Topics: Adult; Amebicides; Dysentery, Amebic; Humans; Male; Metronidazole; Tuberculosis, Hepatic; Tuberculos | 1976 |