metronidazole has been researched along with Jaw, Edentulous, Partially in 1 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Jaw, Edentulous, Partially: Absence of teeth from a portion of the mandible and/or maxilla.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-six implants in 24 partially dentate patients with moderate to advanced peri-implantitis were treated using an anti-infective surgical protocol incorporating open flap debridement and implant surface decontamination, with adjunctive systemic amoxicillin and metronidazole." | 3.78 | Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study. ( Faddy, M; Heitz-Mayfield, LJA; Lang, NP; Mombelli, A; Salvi, GE, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heitz-Mayfield, LJA | 1 |
| Salvi, GE | 1 |
| Mombelli, A | 1 |
| Faddy, M | 1 |
| Lang, NP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of a Toothpaste Containing 0.3% Triclosan in the Maintenance Phase of Peri-implantitis Treatment.[NCT03191721] | Phase 3 | 102 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| The Evaluation of Clinical, Microbiological and Immunological Parameters After Using Photodynamic Therapy in the Surgical Treatment of Peri-implantitis: Randomized Clinical Trials.[NCT05187663] | 50 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for metronidazole and Jaw, Edentulous, Partially
| Article | Year |
|---|---|
Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Debridement; Decontamination; Dental Pros | 2012 |
Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Debridement; Decontamination; Dental Pros | 2012 |
Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Debridement; Decontamination; Dental Pros | 2012 |
Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Debridement; Decontamination; Dental Pros | 2012 |