metronidazole has been researched along with Clonorchiasis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Clonorchiasis: Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with praziquantel followed by metronidazole and tinidazole reduced abnormalities in the liver and eosinophilia." | 1.36 | A case of probable mixed-infection with Clonorchis sinensis and Fasciola sp.: CT and parasitological findings. ( Choi, WH; Chu, JP; Kim, JJ; Kim, TY; Lee, YS; Oh, IH; Song, HO; Yun, JH, 2010) |
| "Clonorchiasis and opisthorchiasis are snail-transmitted trematode infections." | 1.29 | Clonorchiasis/opisthorchiasis in Malaysians case reports and review. ( Lee, SH; Nazarina, AR; Pathmanathan, R; Shekhar, KC, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, TY | 1 |
| Lee, YS | 1 |
| Yun, JH | 1 |
| Kim, JJ | 1 |
| Choi, WH | 1 |
| Oh, IH | 1 |
| Song, HO | 1 |
| Chu, JP | 1 |
| Shekhar, KC | 1 |
| Nazarina, AR | 1 |
| Lee, SH | 1 |
| Pathmanathan, R | 1 |
| Most, H | 1 |
1 review available for metronidazole and Clonorchiasis
| Article | Year |
|---|---|
Drug therapy. Treatment of common parasitic infections of man encountered in the United States. 2.
Topics: Amebiasis; Amebicides; Anthelmintics; Antimalarials; Antimony; Benzenesulfonates; Chloroquine; Clono | 1972 |
2 other studies available for metronidazole and Clonorchiasis
| Article | Year |
|---|---|
A case of probable mixed-infection with Clonorchis sinensis and Fasciola sp.: CT and parasitological findings.
Topics: Adult; Animals; Anthelmintics; Antibodies, Protozoan; Clonorchiasis; Clonorchis sinensis; Entamoeba | 2010 |
Clonorchiasis/opisthorchiasis in Malaysians case reports and review.
Topics: Animals; Clonorchiasis; Clonorchis sinensis; Female; Humans; Male; Metronidazole; Middle Aged; Opist | 1995 |