metronidazole has been researched along with Anasarca in 22 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a 70-year-old female with a medical history of CML, diabetes, hypertension, and hypercholesterolemia who presented to our dermatology clinic for chief complaint of worsening edematous facial rash beginning after initiation of dasatinib." | 8.12 | Facial Edema Associated with Dasatinib: Case Report with Successful Treatment. ( Ambur, A; Nathoo, R; Nyckowski, T; Vinokurov, A, 2022) |
| "We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice." | 7.72 | Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice. ( Ito, Y; Nishimuta, K, 2003) |
| "We present a 70-year-old female with a medical history of CML, diabetes, hypertension, and hypercholesterolemia who presented to our dermatology clinic for chief complaint of worsening edematous facial rash beginning after initiation of dasatinib." | 4.12 | Facial Edema Associated with Dasatinib: Case Report with Successful Treatment. ( Ambur, A; Nathoo, R; Nyckowski, T; Vinokurov, A, 2022) |
| " We used our previously developed in vivo zebrafish model of inducible podocyte-targeted injury and found that triptolide or the inhibition of p53 and gadd45ba with morpholino (MO) alleviated metronidazole (MTZ) induced edema in zebrafish, while the overexpression of gadd45ba in podocytes blocked the protective effect of triptolide and p53 MO on podocyte injury in zebrafish." | 3.91 | Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B. ( Chen, Z; Hou, Q; Li, Z; Liu, Z; Qin, W; Wang, L; Xu, C; Zhai, X; Zhang, L, 2019) |
| "We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice." | 3.72 | Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice. ( Ito, Y; Nishimuta, K, 2003) |
| "This report describes a 3-year-old child who presented with generalised oedema and hypoproteinaemia owing to giardiasis, was treated with oral metronidazole and recovered fully 10 days after therapy." | 3.71 | Giardiasis as the cause of oedema and hypoproteinaemia in a child. ( Harmanci, K; Ozbek, N; Ozçay, F, 2002) |
| "The occurrence of postoperative pain, swelling, trismus, SSI and AO were compared between the groups." | 2.76 | Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study. ( Akadiri, AO; Arotiba, JT; Fasola, OA; Olusanya, AA, 2011) |
| "Amoxicillin was the most frequently prescribed antibiotic." | 1.32 | Pattern of antibiotic prescription in the management of oral diseases among dentists in Kuwait. ( Adib, SM; Al-Mutawa, S; Rotimi, VO; Salako, NO, 2004) |
| "There are many skin manifestations of Crohn's disease including specific lesions occurring late after digestive signs." | 1.29 | [Vulvar involvement in Crohn disease]. ( Doassans, S; Guillot, B; Joujoux, JM; Osman, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Nyckowski, T | 1 |
| Ambur, A | 1 |
| Vinokurov, A | 1 |
| Nathoo, R | 1 |
| Granese, R | 1 |
| Calagna, G | 1 |
| Morabito, G | 1 |
| Carriero, C | 1 |
| Perino, A | 1 |
| Tonni, G | 1 |
| Romano, C | 1 |
| Zhai, X | 1 |
| Wang, L | 1 |
| Xu, C | 1 |
| Hou, Q | 1 |
| Zhang, L | 1 |
| Li, Z | 1 |
| Qin, W | 1 |
| Liu, Z | 1 |
| Chen, Z | 1 |
| Gonsalves, SR | 1 |
| Lobo, GJ | 1 |
| Mendonca, N | 1 |
| Koon, HW | 1 |
| Ho, S | 1 |
| Hing, TC | 1 |
| Cheng, M | 1 |
| Chen, X | 1 |
| Ichikawa, Y | 1 |
| Kelly, CP | 1 |
| Pothoulakis, C | 1 |
| O'Connell, S | 1 |
| Yeaton, K | 1 |
| Kwok, J | 1 |
| Lawford, AM | 1 |
| Scott, K | 1 |
| Lust, K | 1 |
| Olusanya, AA | 1 |
| Arotiba, JT | 1 |
| Fasola, OA | 1 |
| Akadiri, AO | 1 |
| Kromberg, R | 1 |
| Mozet, C | 1 |
| Fritzsch, D | 1 |
| Dawczynski, J | 1 |
| Dietz, A | 1 |
| Nishimuta, K | 1 |
| Ito, Y | 1 |
| Nassir, E | 1 |
| Awad, J | 1 |
| Abel, AB | 1 |
| Khoury, J | 1 |
| Shay, M | 1 |
| Lejbkowicz, F | 1 |
| Salako, NO | 1 |
| Rotimi, VO | 1 |
| Adib, SM | 1 |
| Al-Mutawa, S | 1 |
| Utikal, J | 1 |
| Poenitz, N | 1 |
| Kurzen, H | 1 |
| Goerdt, S | 1 |
| Kularatne, SA | 1 |
| Kumarasiri, PV | 1 |
| Pushpakumara, SK | 1 |
| Dissanayaka, WP | 1 |
| Ariyasena, H | 1 |
| Gawarammana, IB | 1 |
| Senanayake, N | 1 |
| Gray, B | 1 |
| Harper, WF | 1 |
| Still, RM | 1 |
| Doassans, S | 1 |
| Osman, H | 1 |
| Joujoux, JM | 1 |
| Guillot, B | 1 |
| Barrett, AP | 1 |
| Schifter, M | 1 |
| Bourrat, E | 1 |
| Faure, C | 1 |
| Vignon-Pennamen, MD | 1 |
| Rybojad, M | 1 |
| Morel, P | 1 |
| Navarro, J | 1 |
| Watsky, KL | 1 |
| Ozçay, F | 1 |
| Harmanci, K | 1 |
| Ozbek, N | 1 |
| Sucs, FE | 1 |
| Zanen, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Routine vs. Clinically-Directed Antibiotic Treatment in Snake Bite With Local Envenomation: a Randomised Controlled Trial[NCT02570347] | Phase 4 | 130 participants (Anticipated) | Interventional | 2016-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Anasarca
| Article | Year |
|---|---|
Vulvar involvement in pediatric Crohn's disease: a systematic review.
Topics: Administration, Oral; Administration, Topical; Child; Crohn Disease; Edema; Female; Humans; Metronid | 2018 |
3 trials available for metronidazole and Anasarca
| Article | Year |
|---|---|
Prophylaxis versus pre-emptive antibiotics in third molar surgery: a randomised control study.
Topics: Administration, Oral; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Antibi | 2011 |
Routine antibiotic therapy in the management of the local inflammatory swelling in venomous snakebites: results of a placebo-controlled study.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Edema; Female; Humans; Inflammation; Lower Ex | 2005 |
[Open, noncomparative multicenter study of the efficacy and tolerance of a spiramycin-metronidazole combination used in infectious oral pathology].
Topics: Bacterial Infections; Cellulitis; Drug Combinations; Dry Socket; Edema; Humans; Metronidazole; Mouth | 1991 |
18 other studies available for metronidazole and Anasarca
| Article | Year |
|---|---|
Facial Edema Associated with Dasatinib: Case Report with Successful Treatment.
Topics: Aged; Antineoplastic Agents; Dasatinib; Edema; Exanthema; Face; Female; Gels; Humans; Leukemia, Myel | 2022 |
Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B.
Topics: Animals; Antigens, Differentiation; Diterpenes; Edema; Epoxy Compounds; Glomerular Filtration Barrie | 2019 |
Truth under a masquerade!
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ceftriaxone; Diagnosis, Differential; Edema; | 2013 |
Fidaxomicin inhibits Clostridium difficile toxin A-mediated enteritis in the mouse ileum.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacterial Toxins; Clostri | 2014 |
An audit to assess compliance with antimicrobial prescribing in the management of acute dentoalveolar infections with associated facial swelling.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Audit; Dental Service, Hospital; Drainage; Drug Administr | 2014 |
A case of massive vulvar oedema due to septic pubic symphysitis complicating pregnancy.
Topics: Adult; Anti-Bacterial Agents; C-Reactive Protein; Ceftriaxone; Edema; Female; Fever; Gentamicins; Hu | 2010 |
[A rare complication of acute sinusitis].
Topics: Aged; Cavernous Sinus Thrombosis; Cefuroxime; Combined Modality Therapy; Decompression, Surgical; Di | 2012 |
Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Antipruritics; Capillary Permeability; D | 2003 |
Blastocystis hominis as a cause of hypoalbuminemia and anasarca.
Topics: Animals; Anti-Infective Agents; Blastocystis hominis; Blastocystis Infections; Edema; Female; Humans | 2004 |
Pattern of antibiotic prescription in the management of oral diseases among dentists in Kuwait.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Clinical Com | 2004 |
[Persistent facial erythema and edema].
Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents; Diagnosis, Differential; Edem | 2005 |
The effect of metronidazole therapy on cervical histology in trichomoniasis.
Topics: Edema; Epithelium; Female; Hemorrhage; Humans; Hyperplasia; Leukocytes; Metronidazole; Trichomonas V | 1967 |
[Vulvar involvement in Crohn disease].
Topics: Adult; Crohn Disease; Edema; Female; Humans; Metronidazole; Vulvar Diseases | 1994 |
Antibiotic strategy in orofacial/head and neck infections in severe neutropenia.
Topics: Adolescent; Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Bacterial Infections; Clinical Prot | 1994 |
[Anitis, vulvar edema and macrocheilitis disclosing Crohn disease in a child: value of metronidazole].
Topics: Cheilitis; Child; Crohn Disease; Edema; Female; Granuloma; Humans; Metronidazole; Proctitis; Treatme | 1997 |
Acute generalized exanthematous pustulosis induced by metronidazole: the role of patch testing.
Topics: Adult; Anti-Infective Agents; Drug Eruptions; Edema; Erythema; Exanthema; Humans; Male; Metronidazol | 1999 |
Giardiasis as the cause of oedema and hypoproteinaemia in a child.
Topics: Antitrichomonal Agents; Edema; Female; Giardiasis; Humans; Hypoproteinemia; Infant; Metronidazole | 2002 |
[Ocular manifestations secondary to giardiasis].
Topics: Adrenal Cortex Hormones; Adult; Drug Therapy, Combination; Edema; Female; Giardiasis; Humans; Intest | 1986 |